Spontaneous regression of a cystic peripancreatic tumor in a 12-year-old boy: A case report

AbstractWe present a case of spontaneous regression of a cystic peripancreatic tumor in a 12-year-old boy. The cystic tumor was initially suspected to be a pancreatic pseudocyst associated with traumatic pancreatic damage. However, the differential diagnosis included the possibility of lymphatic malformation in view of the clinical and image findings. In anticipation of spontaneous regression, the patient has been followed without treatment. Elective drainage is available but fortunately the cyst has shown no sign of expansion. Close surveillance may be a treatment option for a cystic peripancreatic tumor

Traumatic renal artery occlusion associated with a grade III hepatic injury in an 11-year-old boy: A case report

AbstractBlunt trauma represents a major cause of death in children. Multi-trauma is defined as life-threatening injury of two or more body regions and remains a challenge for diagnosis and therapy. Here, we present a case of an 11-year-old boy with a traumatic renal artery occlusion associated with a hepatic injury, which was treated with conservative non-operative treatment. Prompt diagnosis and conservative treatment of a traumatic renal artery occlusion in a pediatric patient may lead to a successful outcome, avoiding unnecessary laparotomy

Fundamental and higher eigenmodes of qPlus sensors with a long probe for vertical-lateral bimodal atomic force microscopy

The detection of vertical and lateral forces at the nanoscale by atomic force microscopy (AFM) reveals various mechanical properties on surfaces. The qPlus sensor is a widely used force sensor, which is built from a quartz tuning fork (QTF) and a sharpened metal probe, capable of high-resolution imaging in viscous liquids such as lubricant oils. Although a simultaneous detection technique of vertical and lateral forces by using a qPlus sensor is required in the field of nanotribology, it has still been difficult because the torsional oscillations of QTFs cannot be detected. In this paper, we propose a method to simultaneously detect vertical and lateral force components by using a qPlus sensor with a long probe. The first three eigenmodes of the qPlus sensor with a long probe are theoretically studied by solving a set of equations of motion for the QTF prong and probe. The calculation results were in good agreement with the experimental results. It was found that the tip oscillates laterally in the second and third modes. Finally, we performed friction anisotropy measurements on a polymer film by using a bimodal AFM utilizing the qPlus sensor with a long probe to confirm the lateral force detection

Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.

Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia and inflammatory diseases. Because anti-HTLV-1 immune responses are critical for suppressing infected cells, enhancing cellular immunity is beneficial for the treatment of HTLV-1-associated diseases. Using simian T-cell leukemia virus type 1 (STLV-1) infected Japanese macaques, we analyzed the immune responses to viral antigens and the dynamics of virus-infected cells. The chemokine receptor CCR4 is expressed on STLV-1 infected cells, and administration of humanized monoclonal antibody to CCR4, mogamulizumab, dramatically decreased the number of STLV-1-infected cells in vivo. Concurrently, mogamulizumab treatment enhanced STLV-1 specific CD4[+] and CD8[+] T cell responses by simultaneously targeting CCR4[+] effector regulatory T (Treg) cells and infected cells. Mogamulizumab promoted the phagocytosis of CCR4[+] infected cells by macrophages, which likely enhanced antigen presentation. Vaccination with recombinant vaccinia virus (rVV) expressing viral antigens suppressed the proviral load and the number of Tax-expressing cells. Enhanced T-cell responses were also observed in some ATL patients who were treated with mogamulizumab. This study shows that mogamulizumab works not only by killing CCR4[+] infected cells directly, but also by enhancing T cell responses by increasing the phagocytosis of infected cells by antigen-presenting cells and suppressing CCR4[+] effector Treg cells

Perianal human tail with lower imperforate anus: A case report

The human tail is usually attached to the sacrococcygeal skin. However, few reports of the human tail at the perineal or perianal region have been described. Moreover, the tails are rarely accompanied with anorectal malformations (ARMs). Although the exact relationship between the human tail at the perineal or perianal region and ARM remains obscure, we consider that the human tail at the sacrococcygeal region and the perineal or perianal region may have a slightly different mechanism of development

<原著>成熟ラットにおける TPN の肝ミトコンドリア機能に対する影響

To evaluate the effects of TPN on the hepatic function, the changes in hepatic energy charge levels, oxidative and phosphorylative activities of mitochondria and serum transaminase were studied, using male Sprague-Dawley rats 240 to 250 gin weight. The rats were randomized into three groups. The first group (TPN-V group, n=6) was infused with TPN solution via the right jugler vein. The number of calories of TPN solution infused daiary was adjusted to provide each rat with 80 kcal/kg/day on the 1st day, 160 kcal/kg/day on the 2nd day and 240 kcal/kg/day on the 3rd day. After the 4th day, 240 kcal/kg/day was given to both groups. The second group (TPN-G group, n=5) was infused with the same solution via an intragastric route and was given the same calories as the TPN-V group. The third group (control group, n=6) was given a chow diet with the same calories as the TPN group. At the 13th day, all groups were sacrificed, and the hepatic energy charge (EC) and phosphorylation rate (PR) of hepatic mitochondria were measured, and liver function tests were done. PR was 101. 2±5. 0 nmol/mg protein/min in control group, 120. 8±2. 7 in TNP G group and 136. 5±6. 2 in TPN-V group. EC was 0. 906±0. 006, 0. 889±0. 008, 0. 831±0. 010, respectively. The liver function tests of all group were normal. In both TPN groups, despite evidence that liver function tests were normal, enhanced michodrial phosphorylative activity was observed during the early stage of TPN. The mitochondrial enhancement in the TPN-G group was smaller than that in TPN V group. This result suggested that TPN places a load on liver mitochondria and that long term TPN may induce hepatic failure.TPN の肝機能への影響を調べるために, 肝 Energy charge, 肝ミトコンドリア酸化的リン酸化能及び血清トランスアミラーゼ等の変化を検討した. 実験は 240 - 250 g の SD ラットを用い, 右頸静脈から高カロリー輸液を投与した群(以下 TPN-V 群, n=6), 同様の高カロリー輸液を胃痘から投与した群(以下TPN-G 群, n=5)及び上記2群と同カロリーの飼料を投与した群(以下コントロール群, n=6)の3群に分け比較検討した. 各群とも13日間 240 Kcal/kg/日のカロリーを投与した. しかし, 最初2日間は80 Kcal/kg/日(一日目), 160 Kcal/kg/日(2日目)と漸増させていき, 3日目以降に Full dose とした. 実験開始14日目に屠殺し肝を摘出, 肝ミトコンドリアを分離し肝 Energy charge, 肝ミトコンドリア機能を測定した. 結果は肝ミトコンドリア酸化的リン酸化能がコントロール群では 101. 2±5. 0 nmol/mg protein/min, TPN-G 群では120. 8±2. 7 nmol/mg protein/min, そしてTPN-V 群では136. 5±6. 2nmol/mg protein/min, であった. 一方肝 Energy charge は各々 0. 906±0. 006, 0. 889±0. 008 そして0. 831±0. 010 であった. これらの結果より TPN のカロリーの負荷が肝ミトコンドリア機能を元進させるが, 肝 Energy charge を低下させることが分かった