A trend analysis and sub-regional distribution in number of people living with HIV and dying with TB in Africa, 1991 to 2006

<p>Abstract</p> <p>Background</p> <p>The tuberculosis (TB) bacillus and the Human Immunodeficiency Virus (HIV) have formed a powerful alliance and are together responsible for more than five million deaths per year. TB is leading to increased mortality rates among people living with HIV/acquired immunodeficiency syndrome (AIDS). The aim of this study was to investigate the geographical and temporal distribution of TB-HIV deaths in Africa in order to identify possible high-risk areas.</p> <p>Methods</p> <p>Time trends in the 16-year study period from 1990 to 2005 were analyzed by multilevel Poisson growth curve models. Moran global and local indicators of spatial associations were used to test for evidence of global and local spatial clustering respectively.</p> <p>Results</p> <p>Eastern, Southern, Western, and Middle Africa experienced an upward trend in the number of reported TB-HIV deaths. The spatial distribution of TB cases was non-random and clustered, with a Moran's I = 0.454 (p = .001). Spatial clustering suggested that 13 countries were at increased risk of TB-HIV deaths, and six countries could be grouped as "hot spots".</p> <p>Conclusion</p> <p>Evidence shows that there is no decline in growth in the number of deaths due to TB among HIV positive in most Africa countries. There is presence of 'hot-spots' and very large differences persist between sub-regions. Only by tackling TB and HIV together will progress be made in reversing the burden of both diseases. There is a great need for scale-up of preventive interventions such as the World Health Organization '3I's strategy' (intensified case finding, isoniazid preventive therapy and infection control).</p

Stabilized large mode area in tapered photonic crystal fiber for stable coupling

A rigorous modal solution approach based on the numerically efficient finite element method (FEM) has been used to design a tapered photonic crystal fiber with a large mode area that could be efficiently coupled to an optical fiber. Here, for the first time, we report that the expanded mode area can be stabilized against possible fabrication tolerances by introducing a secondary surrounding waveguide with larger air holes in the outer ring. A full-vectorial -field approach is employed to obtain mode field areas along the tapered section, and the Least Squares Boundary Residual (LSBR) method is used to obtain the coupling coefficients to a butt-coupled fiber

Ultra low bending loss equiangular spiral photonic crystal fibers in the terahertz regime

An Equiangular Spiral Photonic Crystal Fiber (ES-PCF) design in Topas® for use in the Terahertz regime is presented. The design shows ultra low bending loss and very low confinement loss compared to conventional Hexagonal PCF (H-PCF). The ES-PCF has excellent modal confinement properties, together with several parameters to allow the optimization of the performance over a range of important characteristics. A full vector Finite Element simulation has been used to characterize the design which can be fabricated by a range of techniques including extrusion and drilling

Economic Evaluations of Adult Male Circumcision for Prevention of Heterosexual Acquisition of HIV in Men in Sub-Saharan Africa: A Systematic Review

Peer reviewedPublisher PD

Combustion kinetics of Shankodi-Jangwa coal

The lack of comprehensive data on the fuel properties of newly discovered coal deposits in Nigeria has hampered the prospective utilisation for power generation. Consequently, this study is aimed at characterising the physicochemical and thermokinetic properties of Shankodi-Jangwa (SKJ) coal recently discovered in Nassarawa state, Nigeria. The results indicate that SKJ comprises 40.50% fixed carbon, 43.34% volatile matter, and 2.36% sulphur with a higher heating value (HHV) of 27.37 MJ kg-1. Based on this HHV, SKJ was classified as high-volatile B bituminous coal. Thermal analysis of SKJ under oxidative thermogravimetry (TG) at multiple heating rates revealed that SKJ is highly reactive and thermally degradable below 1000°C. Kinetic analysis using the Flynn-Wall-Ozawa model for conversions α = 0.05-0.90 revealed the activation energy to range from Ea = 113-259 kJ mol-1, with the frequency factor ranging from A = 2.9 × 1013-1.5 × 1023 min-1 and a range in R2 = 0.8536-0.9997; the average values of these ranges are Ea = 184 kJ mol-1, A = 9.2 × 1023 min-1 and R2 = 0.9420, respectively. The study highlighted fuel property data vital for modelling and designing future SKJ coal power generation

Design and Characterization of Porous Core Polarization Maintaining Photonic Crystal Fiber for THz Guidance

An improved design of Teflon photonic crystal fiber with a porous air-core is presented for low-loss terahertz guidance. Optimization of total power confinement in the air-holes, together both in the cladding and core regions, is carried out for both quasi-TE and quasi-TM polarizations by using a full-vectorial finite element method. To achieve the polarization maintenance, modal birefringence is enhanced by destroying the circular symmetry with the introduction of unequal size air-holes in the first ring

Characterization of graphene-based devices for THz Systems

The H-field finite element method (FEM) based full-vector formulation is used in the present work to study the vectorial modal field properties and the complex propagation characteristics of Surface Plasmon modes of a hollow-core dielectric coated rectangular waveguide structures, and graphene based structures. Additionally, the finite difference time domain (FDTD) method is used to estimate the dispersion parameters and the propagation loss of such waveguides and devices

Characterization of low-loss waveguides and devices for terahertz radiation

. A rigorous full-vectorial modal solution approach based on the finite element method is used to find the propagation properties of terahertz (THz) waveguides, such as photonic crystal fibers, quantum cascaded lasers, plasmonic waveguides, power splitters, and narrow-band filters. Design approaches to reduce the modal loss due to the material and leakage loss in photonic crystal fibers and in metal-coated hollow-glass plasmonic waveguides have also been considered. The plasmonic confinement and gain threshold of quantum cascaded lasers used as THz sources and the chromatic dispersion in plasmonic waveguides are also presented

Low-loss Waveguides and Devices for Compact THz Systems

A rigorous full-vectorial modal solution approach based on the finite element method is used to find the propagation properties of THz waveguides. Design approaches are presented to reduce the modal loss. Design of several THz devices, including quantum cascade lasers, plasmonic waveguides, power splitters and narrow-band filters are also presented

Design and Characterization of Low-Loss Porous-Core Photonic Crystal Fiber

A rigorous modal solution approach, based on the numerically efficient finite-element method (FEM), has been used to design and characterize a photonic crystal fiber (PCF) with a porous air core, which has the potential for use for low-loss guidance of terahertz (THz) waves. Here, for the first time, it is reported that a large fraction of the power that is also well confined in the waveguide can be guided in the low-loss air holes, thus to reduce the overall modal loss. This novel PCF design can readily be fabricated by use of a range of techniques including stack-and-draw, extrusion, and drilling