Antiinflammatory, Analgesic, and Antipyretic Effects of An Aqueous Extract of Erythraea-Centaurium

WOS: A1991EY91700008PubMed ID: 2062955Erythraea centaurium is a plant which is used in the treatment of various inflammatory conditions in popular medicine. The aqueous extract of the plant has been examined for its antiinflammatory, analgesic, and antipyretic effects in several animal models. The extract exhibited antiinflammatory and antipyretic activity although no analgesic activity was observed

Tirenin Tarihi Ticari Yapilari: Bedesten, Hanlar, Arasta, Carsi

Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Design Informatic

Antiinflammatory, analgesic, and antipyretic effects of an aqueous extract of Erythraea centaurium

PubMed ID: 2062955Erythraea centaurium is a plant which is used in the treatment of various inflammatory conditions in popular medicine. The aqueous extract of the plant has been examined for its antiinflammatory, analgesic, and antipyretic effects in several animal models. The extract exhibited antiinflammatory and antipyretic activity although no analgesic activity was observed

Effects of vitamin C treatment on collar-induced intimal thickening

WOS: 000366530900003PubMed ID: 26719672Vitamin C has efficient antioxidant properties and is involved in important physiological processes such as collagen synthesis. As such, vitamin C deficiency leads to serious complications, including vascular diseases. The aim of this study was to investigate the effects of vitamin C treatment on collar-induced intimal thickening. Rabbits were fed a normocholesterolemic diet and a non-occlusive silicon collar was placed around the left carotid artery for 3, 7, and 14 days. The rabbits were treated with or without vitamin C (150 mg/kg/day). Collar-induced intimal thickening became apparent at day 7. The effect of the collar on intimal thickening was more prominent at day 14. Vitamin C treatment significantly inhibited collar-induced intimal thickening at day 14. The placement of the collar around the carotid artery decreased maximum contractile responses against contractile agents (KCl, phenylephrine, 5-hydroxytryptamine). The effect of the collar on contractile responses was enhanced as days elapsed. Decreased contractile responses of collared carotid arteries normalized at day 14 in the vitamin C treatment group. Vitamin C treatment also restored sensitivity to phenylephrine. The collar also significantly decreased acetylcholine-induced relaxations at day 3 and day 7. Acetylcholine-induced relaxations normalized in collared-arteries in the placebo group at day 14. Vitamin C treatment significantly increased acetylcholine-induced relaxations of both normal and collared carotid arteries at day 14. MMP-9 expression increased in collared arteries at day 3 and day 7 but did not change at day 14. MMP-2 expression increased in collared arteries at day 14. However, vitamin C treatment reduced collar-stimulated expression of MMP-2 at day 14. These findings indicate that vitamin C may have potentially beneficial effects on the early stages of atherosclerosis. Furthermore these results, for the first time, may indicate that vitamin C can also normalize decreased contractile response through perivascular collar placement.Scientific Research Foundation of Ege University, Izmir, TurkeyEge UniversityThis research was supported by the Scientific Research Foundation of Ege University, Izmir, Turkey

Mass-Spectral Characterization of 2 Onion Constituents With Prostaglandin-E-Like Activity As Lipoxygenase Metabolites of Linoleic-Acid

WOS: A1984TU2250003