1 research outputs found
Bioactivities of Ethanolic Extract and its Fractions of Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii Boiss. (Lamiaceae) Species
Background: Cistus laurifolius L. (Cistaceae) and Salvia wiedemannii
Boiss. (Lamiaceae) have been used for treatment of some illnesses in
Turkish folk medicine. In the present study, the ethanolic extract and
its fractions obtained using re-extraction by hexane (Hx), chloroform
(CHCl3), butanol, and remaining-water (r-H2O) of C. laurifolius were
screened for their in vitro bioactivities. Materials and Methods:
Activities were determined against both standard and the isolated
strains of Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis,
Klebsiella pneumoniae, Acinetobacter baumannii, Staphylococcus aureus,
Enterococcus faecalis, as well as yeasts such as Candida albicans and
Candida parapsilosis by microdilution method. Also, antiviral activity
of C. laurifolius and S. wiedemannii extracts were tested on herpes
simplex virus-1 (HSV-1) and parainfluenza-3 (PI-3) using Madin-Darby
bovine kidney and vero cell lines. Results: Tested extracts of C.
laurifolius (minimum inhibitory concentration 32 mu g/mL) exerted a
strong antimicrobial activity against Gram-negative bacteria of E. coli,
P. mirabilis, K. pneumoniae, and A. baumannii. Conclusion: The Hx
extract of C. laurifolius (cytopathogenic effect of 32-8 mu g/mL) had
antiviral activity on PI-3. Also, the r-H2O, CHCl3, and ethanol extracts
(16-<0.25 mu g/mL) of S. wiedemannii had significant antiviral activity
on HSV-1, same as control