Coherence of a field-gradient-driven singlet-triplet qubit coupled to many-electron spin states in 28Si/SiGe

Engineered spin-electric coupling enables spin qubits in semiconductor nanostructures to be manipulated efficiently and addressed individually. While synthetic spin-orbit coupling using a micromagnet is widely used for driving qubits based on single spins in silicon, corresponding demonstration for encoded spin qubits is so far limited to natural silicon. Here, we demonstrate fast singlet-triplet qubit oscillation (~100 MHz) in a gate-defined double quantum dot in $^{28}$Si/SiGe with an on-chip micromagnet with which we show the oscillation quality factor of an encoded spin qubit exceeding 580. The coherence time $\textit{T}_{2}$* is analyzed as a function of potential detuning and an external magnetic field. In weak magnetic fields, the coherence is limited by fast noise compared to the data acquisition time, which limits $\textit{T}_{2}$* < 1 ${\mu}$s in the ergodic limit. We present evidence of sizable and coherent coupling of the qubit with the spin states of a nearby quantum dot, demonstrating that appropriate spin-electric coupling may enable a charge-based two-qubit gate in a (1,1) charge configuration

Serum Autotaxin Is a Useful Disease Progression Marker in Patients with Primary Biliary Cholangitis

Autotaxin (ATX) is a secreted enzyme metabolized by liver sinusoidal endothelial cells that has been associated with liver fibrosis. We evaluated serum ATX values in 128 treatment-naive, histologically assessed primary biliary cholangitis (PBC) patients and 80 healthy controls for comparisons of clinical parameters in a case-control study. The median ATX concentrations in controls and PBC patients of Nakanuma's stage I, II, III, and IV were 0.70, 0.80, 0.87, 1.03, and 1.70 mg/L, respectively, which increased significantly with disease stage (r = 0.53, P < 0.0001) as confirmed by Scheuer's classification (r = 0.43, P < 0.0001). ATX correlated with Wisteria floribunda agglutinin-positive Mac-2 binding protein (M2BPGi) (r = 0.51, P < 0.0001) and fibrosis index based on four factors (FIB-4) index (r = 0.51, P < 0.0001). While ALP and M2BPGi levels had decreased significantly (both P < 0.001) by 12 months of ursodeoxycholic acid treatment, ATX had not (0.95 to 0.96 mg/L) (P = 0.07). We observed in a longitudinal study that ATX increased significantly (P < 0.00001) over 18 years in an independent group of 29 patients. Patients succumbing to disease-related death showed a significantly higher ATX increase rate (0.05 mg/L/year) than did survivors (0.02 mg/L/year) (P < 0.01). ATX therefore appears useful for assessing disease stage and prognosis in PBC.ArticleSCIENTIFIC REPORTS.8:8159(2018)journal articl

EGUIDE project and treatment guidelines

Aim: Although treatment guidelines for pharmacological therapy for schizophrenia and major depressive disorder have been issued by the Japanese Societies of Neuropsychopharmacology and Mood Disorders, these guidelines have not been well applied by psychiatrists throughout the nation. To address this issue, we developed the ‘Effectiveness of Guidelines for Dissemination and Education in Psychiatric Treatment (EGUIDE)’ integrated education programs for psychiatrists to disseminate the clinical guidelines. Additionally, we conducted a systematic efficacy evaluation of the programs. Methods: Four hundred thirteen out of 461 psychiatrists attended two 1‐day educational programs based on the treatment guidelines for schizophrenia and major depressive disorder from October 2016 to March 2018. We measured the participants’ clinical knowledge of the treatment guidelines using self‐completed questionnaires administered before and after the program to assess the effectiveness of the programs for improving knowledge. We also examined the relation between the participants’ demographics and their clinical knowledge scores. Results: The clinical knowledge scores for both guidelines were significantly improved after the program. There was no correlation between clinical knowledge and participant demographics for the program on schizophrenia; however, a weak positive correlation was found between clinical knowledge and the years of professional experience for the program on major depressive disorder. Conclusion: Our results provide evidence that educational programs on the clinical practices recommended in guidelines for schizophrenia and major depressive disorder might effectively improve participants’ clinical knowledge of the guidelines. These data are encouraging to facilitate the standardization of clinical practices for psychiatric disorders

精神看護学授業における病棟見学の効果

精神科入院病棟を見学することは,患者の生活空間である治療的環境とその中にいる患者とを見学することとなり,授業理解に効果があるのではないかと考えた。授業が一回終了後毎に見学した6グループ,全授業が終了後に見学した1グループ,授業だけを受け見学していない1グループ,計8グループ(1グループ・9～12名)に対し,窓・デイルーム・電話に関する生活環境,保護室に関する項目の質問を行い,見学がどのように効果があるかを調査した。その結果,見学は学生に様々な影響を与え,望ましい学習効果がある場合と,方法次第で効果が異なる場合があることが示唆された。Visiting a psychiatric ward consists of seeing patients as well as their environment. For the patients, the ward is not only a therapeutic environment, but where they live their daily lives. We thought that student nurses would understand the lectures about psychiatric nursing much better if they visited a psychiatric ward. Eighty students were divided into eight groups. Six groups visited the ward once during the interval of the lectures, which consisted of seven sessions. One group went to the ward after all the sessions, and the eighth group did not visit the ward. The student nurses were required to take a quiz about the windows of the ward, the day room, telephone, and the seclusion room after all sessions. We compared the quiz scores across the groups. The result showed that visiting a psychiatric ward enabled student nurses to better understand the lectures about psychiatric nursing. However, the effect depended on whether or not students saw patients in the seclusion room and conversed with patients. Students who saw the seclusion rooms with patients and talked with patients scored highest on the quiz. Students were more influenced by first-hand experience than by faculty or ward staff explanations

マシン フウシン スイトウ ムンプス ニ カンスル コウタイカ ケンサホウ ノ ダトウセイ ト カンセン ヨボウ タイサク : カンゴ ガクセイ ノ 3ネンカン ノ ジュウダン チョウサ カラ

予防接種により感染予防が可能な小児期感染症(麻疹、風疹、水痘、ムンプスの4疾患)について、看護学生に対する抗体価検査法の妥当性を得るために、個人の3年間の縦断調査結果を分析した。麻疹(HI法、陰性<8≦陽性)とムンプス(HI法、陰性<8≦陽性)の抗体測定法では、予防接種後の抗体陽転率が82.1%、45.2%であった。風疹(HI法、陰性<8≦陽性)、水痘(EIA法、陰性<2.0≦陽性)に関する現行の抗体測定法では、少数例であったが予防接種後は全員が陽転した。The purpose of this paper is to analyze the results of three&#8209;year longitudinal research on nursing students in order to examine the validity of antibody testing in respects to childhood infections (measles, rubella, chickenpox and mumps) which are preventable by means of vaccination. Measles (HI method, Negative<8≦Positive) and mumps (HI method, Negative<8≦Positive) respectively showed 82.1% and 45.2% a positive conversion ratio of antibody after vaccination. In a few cases, checked by using the current antibody testing, both rubella (HI method, Negative<8≦Positive) and chickenpox (EIA method, Negative<2.0≦Positive) resulted in 100% positive conversion ratio after vaccination

Aガタ ナトリウム リニョウ ペプチド ジュヨウタイ ( Guanylyl Cyclase-A ) ノ 5' リンセツ リョウイキ ニ ソンザイスル CT ニエンキ クリカエシ イデンシ タケイ ト ホンタイセイ コウケツアツ ノ カンレン : ニホンジン ニ オケル ケントウ

京都大学0048新制・論文博士博士(医学)乙第12361号論医博第1984号新制||医||976(附属図書館)27263UT51-2009-F499(主査)教授 稲垣 暢也, 教授 中山 健夫, 教授 松田 文彦学位規則第4条第2項該当Doctor of Medical ScienceKyoto UniversityDA

Fabrication of Silicon Nanowire Metal-Oxide-Semiconductor Capacitors with Al2O3/TiO2/Al2O3 Stacked Dielectric Films for the Application to Energy Storage Devices

Silicon nanowire (SiNW) metal-oxide-semiconductor (MOS) capacitors with Al2O3/TiO2/Al2O3 (ATA) stacked dielectric films were fabricated by metal-assisted chemical etching (MACE) and atomic layer deposition (ALD). High-angle annular dark field scanning transmission electron microscopy (HAADF-STEM) images revealed that SiNWs were conformally coated with ATA although the cross-sectional shapes of MACE-SiNWs were non-uniform and sharp spikes can be seen locally. The dielectric capacitance density of 5.9 μF/cm2 at V = −4 V of the perfect accumulation region was achieved due to the combination of the large surface area of the SiNW array and the high dielectric constant of ATA. The capacitance changed exponentially with the voltage at V &lt; −4.3 V and the capacitance of 84 μF/cm2 was successfully achieved at V = −10 V. It was revealed that not only 3D structure and high-k material but also local nanostructure of SiNWs and stacked dielectric layers could contribute to the considerable high capacitance

Identification of the amino acid residues responsible for cold tolerance in Flaveria brownii pyruvate,orthophosphate dikinase\ud

Pyruvate,orthophosphate dikinase (PPDK), an enzyme important in C4 photosynthesis, is typically a cold-sensitive enzyme. However, a cold-tolerant form of the enzyme has been isolated from the leaves of Flaveria brownii. Using an Escherichia coli expression system and the PPDK cDNAs from F. brownii (cold-tolerant), F. bidentis (cold-sensitive) and maize (intermediate cold tolerance), site-directed mutagenesis studies indicated that as few as three amino acids residues (of 880 residues) strongly influence the cold sensitivity of Flaveria PPDK. Gel filtration analysis of the PPDK expressed in E. coli showed that subunit association and cold tolerance are closely linked