Adropin in women with polycystic ovary syndrome

Introduction: Women with polycystic ovary syndrome (PCOS) frequently develop metabolic complications. Among the newly found factors responsible for metabolic disorders, adropin seems to be of a great significance. Material and methods: In total 134 women aged 17–45 years were enrolled. The PCOS group consisted of 73 women, diagnosed on the basis of Executive Committee of the European Society of Human Reproduction and Embryology — American Society for Reproductive Medicine (ESHRE-ASRM) criteria. All PCOS women presented phenotype A of PCOS. The control group consisted of 61 women with regular menstrual cycles, matched for nutritional status. All women underwent anamnesis, physical examination, anthropometric measurements, abdominal and transvaginal ultrasound, and dual-energy X-ray absorptiometry (DXA). Serum adropin levels were determined by ELISA. Biochemical [fasting glucose and insulin, oral glucose tolerance test, lipid and sex hormone-binding globulin (SHBG)] and hormonal (testosterone, androstenedione, luteinizing hormone, follicle-stimulating hormone and oestradiol) measurements were performed. Insulin resistance indices [(Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), Quantitative Insulin Sensitivity Check Index (QUICKI), Matsuda] and free androgen index (FAI) were calculated according to the standard formula. Results: Serum adropin levels were lower in the PCOS group (0.475 ± 0.200 vs. 0.541 ± 0.220, p = 0.069), but the results were not statistically significant. Positive correlations among adropin and androstenedione levels were observed in the PCOS group (r = 0.27, p = 0.025). Conclusions: Women with PCOS have a different metabolic profile in comparison to women without this syndrome. We did not observe a statistically significant difference in adropin concentration between the PCOS and the healthy control group. Therefore, more studies regarding adropin in PCOS are needed.

The content of resistin in the blood plasma and the activity of non-specific inflammation in patients with type 2 diabetes, depending on body weight and gender

Urbanovych Alina. Содержание резистина в плазме крови и активность неспецифического воспаления у больных сахарным диабетом 2 типа в зависимости от массы тела и пола = The content of resistin in the blood plasma and the activity of non-specific inflammation in patients with type 2 diabetes, depending on body weight and gender. Journal of Education, Health and Sport. 2015;5(11):68-77. ISSN 2391-8306. DOIhttp://dx.doi.org/10.5281/zenodo.33364 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%2811%29%3A68-77 https://pbn.nauka.gov.pl/works/666653 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014http://journal.rsw.edu.pl/index.php/JHS/issue/archive   Deklaracja. Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.09.2015. Revised 05.10.2015. Accepted: 30.10.2015.   Содержание резистина в плазме крови и активность неспецифического воспаления у больных сахарным диабетом 2 типа в зависимости от массы тела и пола The content of resistin in the blood plasma and the activity of non-specific inflammation in patients with type 2 diabetes, depending on body weight and gender   А. М. Урбанович Alina Urbanovych   Львовский национальный медицинский университет имени Данила Галицкого, Украина Lviv National Medical University named Danylo Galyckyi   Abstract Purpose of the research - to establish the correlation of resistin levels in blood plasma and markers of generalized non-specific inflammation in patients with diabetes type 2, depending on the presence of overweight and obesity, gender differences. Material and methods. The study involved 305 patients with diabetes type 2, which which were divided into three groups: group 1 with normal body weight - 43 patients, 2nd with overweight - 88 patients, 3rd with obesity - 174 patients. Were compared the level of resistin and tumor neсkrosis factor α (TNF-α), interleukin (IL)-2, IL-6 in these groups. Results. There were no significant differences in the content of resistin in the blood plasma of patients with type 2 depending on the presence of overweight and obesity. Revealed higher levels of TNF-a and IL-6 in patients of group 1 compared with patients of the 3rd group. During the correlation analysis was revealed a positive correlation of resistin levels with TNF-a and IL-2; insulin in overweight groups (r = 0,3881, p = 0,0004 and r= 0,2733, p = 0,0142; r = 0,2415, p = 0,0343) content resistin levels TNF-a and IL-2 group with obesity (r = 0,3255, p <0,2252 and r =0,0001, p = 0,0037), whereas in the group with normal weight is not detected correlation between resistin level with markers of generalized nonspecific inflammation and insulin levels. The difference in the content of resistin in the blood plasma of women and men, depending on body weight was not revealed. Conclusion. At type 2 diabetes is formed a new level of regulatory connections, where major role refers to the synthesis of cytokines, such as resistin, tumor neсkrosis factor α, interleukins.   Key words: diabetes mellitus type 2, resistin, interleukin-2, interleukin-6, tumor neсkrosis factor α.   Резюме Цель работы – установить взаимосвязь содержания резистина крови и маркеров генерализованного неспецифического воспаления у пациентов с СД 2-го типа в зависимости от наличия избыточного веса и ожирения, гендерних отличий. Материал и методы. Обследовано 305 пациентов с СД 2-го типа, которые были распределены на три группы: 1-я группа с нормальной массой тела - 43 пациента, 2-я с избыточной массой тела - 88 пациентов, 3-я с ожирением - 174 пациента. Сравнивали содержание резистина и туморнекротического фактора- α (TNF-α), интерлейкина (ИЛ)-2, ИЛ-6 в этих группах. Результаты. Не выявлено достоверной разницы в содержании резистина в плазме крови пациентов с СД 2 в зависимости от наличия избыточного веса и ожирения. Выявлено более высокие уровни TNF-a и ИЛ-6 у пациентов 1-й группы по сравнению с пациентами 3-й группы. При проведении корреляционного анализа выявлена положительная корреляция содержания резистина с уровнями TNF-a и ИЛ-2; инсулина в группах с избыточным весом (r = 0,3881, p = 0,0004 и r = 0,2733, p = 0,0142; r = 0,2415, р = 0,0343) содержания резистина с уровнями TNF-a и ИЛ-2 в группе с ожирением (r = 0,3255, p <0,0001та r = 0,2252, p = 0,0037), тогда как в группе с нормальным весом не обнаружено корреляции уровня резистина с маркерами генерализованного неспецифического воспаления и уровнем инсулина. Не установлено разницы в содержании резистина в плазме крови у женщин и мужчин в зависимости от массы тела. Заключение. При СД 2 типа формируется новый уровень регуляторных взаимосвязей, где важное значение имеют изменения в синтезе цитокинов, в частности резистина, туморнекротического фактора α, интерлейкинов. Ключевые слова: сахарный диабет 2 тип, резистин, интерлейкин-2, интерлейкин-6, туморнекротический фактор α

Modern Ways of Treatment of Metabolic Disorders in Women with Polycystic Ovarian Syndrome

Article represents complex approach to PCOS problem from the position of prophylaxis and therapy of metabolic disorders, which include overweight and obesity, insulin resistance, carbohydrate and lipid metabolism deviations. Lifestyle modification specifically including healthy diet was provided as an example. Also, were described medications, which increase insulin sensitivity and method of treatment in case of 3rd class obesity

Hepcidin and Iron Homeostasis in Patients with Subacute Thyroiditis and Healthy Subjects

Purpose. Hepcidin is an acute-phase protein involved also in regulation of iron homeostasis. The aim of the study was to prospectively assess for the first time the hepcidinEL concentration in patients with subacute thyroiditis (SAT), to identify biochemical determinants of hepcidinEL concentration and evaluate the potential role of hepcidin in SAT diagnosis and monitoring. Methods. Out of 40 patients with SAT initially recruited, restrictive inclusion criteria fulfilled 21 subjects aged 45±10 years and 21 healthy control subjects (CS). HepcidinEL concentration, thyroid status, and iron homeostasis were evaluated at SAT diagnosis and following therapy and compared with CS. Results. The median hepcidinEL concentration at SAT diagnosis is higher than that in CS (48.8 (15.9-74.5) ng/mL vs. 18.2 (10.2-23.3) ng/mL, p=0.009) and is significantly lower after treatment (4.0 (1.2-10.0) ng/mL, p=0.007) compared with CS. The ROC analysis for hepcidinEL at SAT diagnosis revealed that area under the curve (AUC) is 0.735 (p=0.009), and the cut-off for hepcidinEL concentration is 48.8 ng/mL (sensitivity 0.52 and specificity 0.95). HepcidinEL in SAT patients correlated with CRP (r=0.614, p=0.003), ferritin (r=0.815, p<0.001), and aTPO (r = -0.491, p=0.024). On multiple regression, the correlation between hepcidinEL and ferritin was confirmed (p<0.001). Conclusions. SAT is accompanied by a significant increase in hepcidin, which reflects an acute-phase inflammatory process. Parameters of iron homeostasis improved significantly while inflammatory indices got lower following recovery. The potential role of hepcidin as a predictive factor of the risk of SAT relapse needs to be assessed in studies on larger groups of SAT patients