Multistorey car park aboveground from concrete

Diplomová práce řeší návrh a posudek hlavních částí čtyřpatrového parkovacího domu ze železobetonu inspirující se reálným investičním záměrem multifunkčního parkovacího domu u Městské nemocnice Ostrava. Původní objekt byl následně trochu pozměněn a v MKP softwaru ve 3D kompletně vymodelován. Na základě programových výsledků vnitřních sil byla dále navržena a posouzena nosná výztuž stropních desek, sloupů, schodiště a rampy podle mezního stavu únosnosti a použitelnosti dle platných norem. Následně byla zpracována výkresová dokumentace výztuže jednotlivých prvků spolu s projektovou dokumentací objektu.The diploma thesis solves the design and assessment of the main parts of the four-storey parking house made of reinforced concrete inspired by the real investment plan of a multifunctional parking house at the Hospital in the Ostrava City. The object was subsequently slightly modified and completely modeled in FEM software in 3D. Based on internal forces results from the software it has also been designed and assessed load-bearing reinforcement of ceiling slabs, columns, staircases and ramps according to the ultimate limit state and serviceability according to valid standards. Subsequently, drawings of reinforcement of individual elements were carried out with project documentation of the object.221 - Katedra konstrukcívelmi dobř

Design and reliability assessment of structural system of restaurant building

Bakalářská práce je zaměřena na návrh a posudek atypické nosné stropní desky jednopodlažní restaurace a jejich podpor dle architektonické studie. Důležitou část tvoří konstrukční návrh jednotlivých variant konstrukce stropu, z nichž byla podle zadaných kritérií vybrána ta nejvhodnější. Vhodné řešení je dále vymodelováno ve 3D v MKP softwaru. Na vnitřní síly získané ze softwaru je následně navrhnuta a posouzena výztuž stropní desky i nosných železobetonových stěn, a to podle mezního stavu únosnosti a použitelnosti dle platných norem. Součástí statického posudku je výkresová dokumentace výztuže stropní desky a studie objektu.The bachelor thesis is focused on the design and reliability assessment of atypical supporting ceiling slabs of one-storey restaurant and their support according to architectural studies. An important part is the structural design of the individual variants of the ceiling construction, from which the most suitable was chosen according to the specified criteria. A suitable solution is elaborated in 3D in FEM software. The internal forces from the software are following designed and assessed for the reinforcement of the ceiling and reinforced concrete walls according to the limit state of loadability and usability according to valid standards. Part of the static review is the drawing documentation of the ceiling slab reinforcement and the study of the building.228 - Katedra stavební mechanikyvelmi dobř

Ověření využitelnosti úpravárenských kalů z hnědouhelných úpraven a.s. MUS ...

Import 20/04/2006Prezenční výpůjčkaVŠB - Technická univerzita Ostrava. Fakulta hornicko-geologická. Institut environmentálního inženýrství (546

Improving risk-stratification of patients with chronic lymphocytic leukemia using multivariate patient similarity networks

Background: Better risk-stratification of patients with chronic lymphocytic leukemia (CLL) and identification of subsets of ultra-high-risk (HR)-CLL patients are crucial in the contemporary era of an expanded therapeutic armamentarium for CLL. Methods: A multivariate patient similarity network and clustering was applied to assess the prognostic values of routine genetic, laboratory, and clinical factors and to identify subsets of ultra-HR-CLL patients. The study cohort consisted of 116 HR-CLL patients (F/M 36/80, median age 63 yrs) carrying del(11q), del(17p)/TP53 mutations and/or complex karyotype (CK) at the time of diagnosis. Results: Three major subsets based on the presence of key prognostic variables as genetic aberrations, bulky lymphadenopathy, splenomegaly, and gender: profile (P)-I (n = 34, men/women with CK + no del(17p)/TP53 mutations), P-II (n = 47, predominantly men with del(11q) + no CK + no del(17p)/TP53 mutations), and P-III (n = 35, men/women with del(17p)/TP53 mutations, with/without del(11q) and CK) were revealed. Subanalysis of major subsets identified three ultra-HR-CLL groups: men with TP53 disruption with/without CK, women with TP53 disruption with CK and men/women with CK+ del(11q) with poor short-term outcomes (25% deaths/12 mo). Besides confirming the combinations of known risk-factors, the used patient similarity network added further refinement of subsets of HR-CLL patients who may profit from different targeted drugs. Conclusions: This study showed for the first time in hemato-oncology the usefulness of the multivariate patient similarity networks for stratification of HR-CLL patients. This approach shows the potential for clinical implementation of precision medicine, which is especially important in view of an armamentarium of novel targeted drugs.Web of Science79686

Complex karyotype as a predictor of high-risk chronic lymphocytic leukemia: A single center experience over 12 years

Objectives: A complex karyotype (CK) is considered a poor prognostic marker in chronic lymphocytic leukemia (CLL). Methods: The study analyzed 644 untreated CLL patients (pts) using conventional/molecular cytogenetics to reveal the presence of a CK and its composition and to assess its predictive value. The mutational status of TP53 was detected by next generation sequencing. Results: A CK was detected in 79 pts (12.3%). Patients with a CK showed shorter overall survival (OS) compared to those without a CK (77 months vs. 115 months, p < 0.0001). Chromosomes most frequently included in a CK were 13, 11, 17, 8, 2, and 6. The most common aberrations in a CK were translocations, numerical changes and dicentric chromosomes (with no effect on OS). Patients with aberrations of TP53 and ATM were shown to have adverse prognosis comparable to patients with a CK without these abnormalities. A stronger impact of a CK on OS of female and older CLL patients was observed. Conclusions: The determining of the presence of a CK is essential in modern clinical CLL practice. According to recent studies, the presence of a CK affects clinical and treatment decision-making.Web of Science85art. no. UNSP 10621