526 research outputs found
RELATIONSHIP BETWEEN REDUCED OF MEDIAL LONGITUDINAL ARCH HEIGHT AND KNEE VALGUS
Knee valgus during jump landing is considered to be one of the situations that may cause injury to the anterior cruciate ligament (ACL). Decreased muscle torque during hip abduction is also reported to be a causative factor for knee valgus, as is pronation of the ankle joint (Joseph M et al. 2008). Further, knee valgus may occur when a reduction in the height of the medial longitudinal arch causes ankle pronation, leading to tibial inclination angle to the inside. In this study, motion analysis was performed to investigate the relationship between a reduction in the height of the medial longitudinal arch and knee valgus
Bubbles, clusters and denaturation in genomic DNA: modeling, parametrization, efficient computation
The paper uses mesoscopic, non-linear lattice dynamics based
(Peyrard-Bishop-Dauxois, PBD) modeling to describe thermal properties of DNA
below and near the denaturation temperature. Computationally efficient notation
is introduced for the relevant statistical mechanics. Computed melting profiles
of long and short heterogeneous sequences are presented, using a recently
introduced reparametrization of the PBD model, and critically discussed. The
statistics of extended open bubbles and bound clusters is formulated and
results are presented for selected examples.Comment: to appear in a special issue of the Journal of Nonlinear Mathematical
Physics (ed. G. Gaeta
Distribution-based bisimulation for labelled Markov processes
In this paper we propose a (sub)distribution-based bisimulation for labelled
Markov processes and compare it with earlier definitions of state and event
bisimulation, which both only compare states. In contrast to those state-based
bisimulations, our distribution bisimulation is weaker, but corresponds more
closely to linear properties. We construct a logic and a metric to describe our
distribution bisimulation and discuss linearity, continuity and compositional
properties.Comment: Accepted by FORMATS 201
Fluctuation of the Top Location and Avalanches in the Formation Process of a Sandpile
We investigate the formation processes of a sandpile using numerical
simulation. We find a new relation between the fluctuation of the motion of the
top and the surface state of a sandpile. The top moves frequently as particles
are fed one by one every time interval T. The time series of the top location
has the power spectrum which obeys a power law, S(f)~f^{\alpha}, and its
exponent \alpha depends on T and the system size w. The surface state is
characterized by two time scales; the lifetime of an avalanche, T_{a}, and the
time required to cause an avalanche, T_{s}. The surface state is fluid-like
when T_{a}~T_{s}, and it is solid-like when T_{a}<<T_{s}. Our numerical results
show that \alpha is a function of T_{s}/T_{a}.Comment: 15 pages, 13 figure
Destabilization of dark states and optical spectroscopy in Zeeman-degenerate atomic systems
We present a general discussion of the techniques of destabilizing dark
states in laser-driven atoms with either a magnetic field or modulated laser
polarization. We show that the photon scattering rate is maximized at a
particular evolution rate of the dark state. We also find that the atomic
resonance curve is significantly broadened when the evolution rate is far from
this optimum value. These results are illustrated with detailed examples of
destabilizing dark states in some commonly-trapped ions and supported by
insights derived from numerical calculations and simple theoretical models.Comment: 14 pages, 10 figure
Water Dynamics at Protein Interfaces: Ultrafast Optical Kerr Effect Study
The behavior of water molecules surrounding a protein can have an important bearing on its structure and function. Consequently, a great deal of attention has been focused on changes in the relaxation dynamics of water when it is located at the protein surface. Here we use the ultrafast optical Kerr effect to study the H-bond structure and dynamics of aqueous solutions of proteins. Measurements are made for three proteins as a function of concentration. We find that the water dynamics in the first solvation layer of the proteins are slowed by up to a factor of 8 in comparison to those in bulk water. The most marked slowdown was observed for the most hydrophilic protein studied, bovine serum albumin, whereas the most hydrophobic protein, trypsin, had a slightly smaller effect. The terahertz Raman spectra of these protein solutions resemble those of pure water up to 5 wt % of protein, above which a new feature appears at 80 cm–1, which is assigned to a bending of the protein amide chain
Nitrides as ammonia synthesis catalysts and as potential nitrogen transfer reagents
In this article, an overview of the application of selected metal nitrides as ammonia synthesis catalysts is presented. The potential development of some systems into nitrogen transfer reagents is also described
Terahertz underdamped vibrational motion governs protein-ligand binding in solution
Low-frequency collective vibrational modes in proteins have been proposed as being responsible for efficiently directing biochemical reactions and biological energy transport. However, evidence of the existence of delocalized vibrational modes is scarce and proof of their involvement in biological function absent. Here we apply extremely sensitive femtosecond optical Kerr-effect spectroscopy to study the depolarized Raman spectra of lysozyme and its complex with the inhibitor triacetylchitotriose in solution. Underdamped delocalized vibrational modes in the terahertz frequency domain are identified and shown to blue-shift and strengthen upon inhibitor binding. This demonstrates that the ligand-binding coordinate in proteins is underdamped and not simply solvent-controlled as previously assumed. The presence of such underdamped delocalized modes in proteins may have significant implications for the understanding of the efficiency of ligand binding and protein–molecule interactions, and has wider implications for biochemical reactivity and biological function
Preparation of amino-substituted indenes and 1,4-dihydronaphthalenes using a one-pot multireaction approach: total synthesis of oxybenzo[c]phenanthridine alkaloids
Allylic trichloroacetimidates bearing a 2-vinyl or 2-allylaryl group have been designed as substrates for a one-pot, two-step multi-bond-forming process leading to the general preparation of aminoindenes and amino-substituted 1,4-dihydronaphthalenes. The synthetic utility of the privileged structures formed from this one-pot process was demonstrated with the total synthesis of four oxybenzo[c]phenanthridine alkaloids, oxychelerythrine, oxysanguinarine, oxynitidine, and oxyavicine. An intramolecular biaryl Heck coupling reaction, catalyzed using the Hermann–Beller palladacycle was used to effect the key step during the synthesis of the natural products
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