A Rare Case of Lung Hypoplasia, Cardiac Anomalies and Ovarian Tumour in a Patient with MRKH Syndrome

Hypoplasia of the lung is an uncommon congenital abnormality of the respiratory system in contrast to Pulmonary agenesis. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the congenital absence of the upper two-thirds of the vagina and uterus with normal secondary sexual characteristics, ovary, and normal karyotype. Here we describe a case of left lung hypoplasia and congenital cardiac malformations with MRKH syndrome and Leiomyoma of the ovary. A 31-year-old female presented with cough with expectoration, left side chest pain and breathlessness for four years to Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER). She was evaluated for amenorrhea and diagnosed as MRKH syndrome and the patient underwent right side oophorectomy for right ovarian torsion with a tumour. Computed Tomography Pulmonary Angiogram (CTPA) and fiberoptic endoscopy were suggestive of left lung hypoplasia, and the patient was advised symptomatic treatment for lung hypoplasia and planned for vaginoplasty. Keywords: Pulmonary hypoplasia, Infertility, Mullerian aplasia, congenital bronchiectasis, Left-sided superior vena cava, ovarian Leiomyoma

Pulmonary infarct as a initial presentation of acute myeloid leukemia: a diagnostic difficulty

The incidence of acute myeloid leukemia (AML) is age dependent and increasing among the patient groups aged above 60 years. The overall presentations in a case of AML is due to marrow infiltration of leukemic cells which results in fever and chills due to neutropenia, bleeding due to thrombocytopenia, fatigue and weakness due to anemia. Incidence of venous thromboembolism is very rare in hematological malignancies. We describe a case of adolescent male presented with features of lung consolidation later found to be a pulmonary infarct and finally diagnosed to have acute leukemia (AL)

Nil Intervention is at Times the Best Intervention: Benign emptying of pneumonectomy space

A sudden drop of air-fluid level in the pneumonectomy space in the absence of a bronchopleural fistula and pleural infection is termed benign emptying of the post pneumonectomy space (BEPS). We herein report a case of benign emptying of pneumonectomy space, briefly review the literature and enumerate possible mechanisms for the same. It is an extremely rare entity and follows a benign course. Patients with BEPS are clinically stable, afebrile with no fluid expectoration, and have a normal white blood cell count. Bronchoscopy reveals an intact bronchial stump and pleural fluid cultures are often sterile. Close monitoring and early detection of a bronchopleural fistula is the management. Clinicians should keep BEPS among the differential diagnosis in case of a drop in the air-fluid level of the post pneumonectomy space. Awareness of this entity is crucial as it helps prevent unnecessary and morbid surgical interventions. Keywords: Pneumonectomy; BEPS; Bronchopleural Fistula; India

An overview of treatment options for COVID-19

Severe acute respiratory syndrome- coronavirus-2 (SARS-CoV-2) which emerged in Wuhan initially as pneumonia of unknown origin in December 2019, later spread to whole world and became pandemic on 11th March, 2020. Many drugs have been proposed but are backed without clinical evidence. Scientific bodies are in the row to discover a reliable vaccine and effective drugs against the novel coronavirus. Many antiviral and anti-parasitic drugs which were thought to have some effect on Coronavirus disease 2019 (COVID-19) have been tried during the crisis but none have shown concrete evidence of action. Randomized clinical trials on the repurposed drugs are now registered under clinical trial registry to look at the safety profile and efficacy of the drugs to be used against SARS-CoV-2. Many meta-analyses are being conducted worldwide to frame evidence for the fight against this novel coronavirus. We are providing below a review of various drugs that have been tried for treatment of COVID-19 as well as different clinical trials which are underway

When attacked by a new enemy, do not forget the old ones. A tale of 2 diseases: tuberculosis and COVID-19

e two diseases together

Endocrine paraneoplastic syndromes in lung cancer: a respiratory physician’s perspective

Lung malignancy is known to be one of the leading causes of cancer-related mortality. Endocrine paraneoplastic syndromes in lung cancer are common. These are due to secretion of various substances and not because of direct tumour invasion or me-tastasis. These syndromes have also been associated with lung cancer prognosis. This review describes the many endocrine paraneoplastic syndromes seen in lung cancer and narrates their incidence, biology, clinical features, diagnosis, and management

When Attacked by a New Enemy, Do Not Forget the Old Ones. A Tale of 2 Diseases: Tuberculosis and COVID-19

COVID-19 (COrona VIrus Diagnosed in 2019) is the most important health crisis of the present generation [...

Endocrine Paraneoplastic Syndromes in Lung Cancer: A Respiratory Physician’s Perspective

Lung malignancy is known to be one of the leading causes of cancer-related mortality. Endocrine paraneoplastic syndromes in lung cancer are common. These are due to secretion of various substances and not because of direct tumour invasion or me-tastasis. These syndromes have also been associated with lung cancer prognosis. This review describes the many endocrine paraneoplastic syndromes seen in lung cancer and narrates their incidence, biology, clinical features, diagnosis, and management

New twist to an old problem: COVID-19 and idiopathic pulmonary fibrosis

Iidiopathic pulmonary fibrosis (IPF) diagnosis and treatment during this COVID-19 pandemic have been affected. COVID-19 has not only impacted the prognosis of these patients but also the approach to these patients. Pulmonary function tests (PFT) and lung biopsies are less encouraged now. Traditional antifibrotics used in IPF should be encouraged irrespective of patient lung function and in those with non-definite usual interstitial pneumonia in high resolution computed tomography

New Twist to An Old Problem: COVID-19 and Idiopathic Pulmonary Fibrosis

Pandemic of COVID-19 has brought a pletho-ra of challenges throughout the world and has opened exposed gaps in already overburdened stressful health system [...