49 research outputs found

    Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

    Get PDF
    This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

    Cognitive Function and Ageing Study - Wales: Waves 1-2, 2011-2016

    No full text
    Abstract copyright UK Data Service and data collection copyright owner.The Cognitive Function and Ageing Study - Wales (CFAS-Wales) is a longitudinal study looking at health and cognitive function in older people living in Wales, building on the design and infrastructure of the successful Cognitive Function and Ageing Study collaboration (CFAS). Recruitment for CFAS Wales began in 2011 with the follow up wave (2 years after initial interview) being completed in early 2016.This study provides data complementing that from an earlier survey conducted in the mid 1990s (CFAS-I), and is closely linked to the MRC-CFAS II project based in three sites in England. MRC CFAS I (1989–2011) included six centres across England and Wales - Cambridgeshire, Gwynedd, Newcastle, Nottingham, Oxford and Liverpool. CFAS II (2008 onwards) included three centres in England - Cambridgeshire, Newcastle and Nottingham. Both studies are available from the Cognitive Function and Ageing Study website. Information about CFAS-Wales is available from the CFAS-Wales webpages and the CFAS-Wales Bangor University website Following on from CFAS-I, the present study established a new cohort of 3,500 older people (aged 65+) enabling an evaluation of changes that have occurred over the last 15 years in lifestyle, including exercise and activities, and people's expectations of ageing, services and families, to be conducted. At wave 2, 2,237 people were re-interviewed. The initial sample was drawn at random from GP lists in the participating areas, with equal numbers from those aged 65-75 and those over 75. People living in care homes were included in the sample. Participants were interviewed in English or Welsh, according to their preference. The aims of CFAS Wales were broad and include examinations of activity and participation, social networks and social resources, health and cognitive function, cognitive reserve and lifestyle factors, resilience and adaptation and environmental influences. The standard CFAS interview has been augmented for CFAS Wales with additional measures relating to loneliness, life satisfaction, resilience, use of Welsh (and other) language(s), and (at wave 2) personality, social cohesion, financial resources and access to services. The interview at each wave includes the CAMCOG cognitive tests, and allows the AGECAT diagnostic algorithms to be run, for dementia, depression and anxiety disorders. Main Topics:Ageing and: health; cognitive function; cognitive reserve; social networks; resilience; nutrition; physical activity; bilingualism

    Additional file 1: of Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

    No full text
    Supplemental tables. (XLSX 62 kb

    Additional file 25 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

    No full text
    Additional file 25: Table S16. Comparison of effect size estimates for sex-stratified analysis in the replication cohorts

    Additional file 2 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

    No full text
    Additional file 2: Table S2. Association results for the multi-ancestry index SNPs with the gene prioritization

    Additional file 18 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

    No full text
    Additional file 18: Table S10. Lambda GC values across minor allele frequency bins for sex-specific meta-analyses

    Additional file 23 of Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

    No full text
    Additional file 23: Table S15. Comparison of the sex-specific effects
    corecore