On the magnetic equation of state in (2+1)-flavor QCD

A first study of critical behavior in the vicinity of the chiral phase transition of (2+1)-flavor QCD is presented. We analyze the quark mass and volume dependence of the chiral condensate and chiral susceptibilities in QCD with two degenerate light quark masses and a strange quark. The strange quark mass (m_s) is chosen close to its physical value; the two degenerate light quark masses (m_l) are varied in a wide range 1/80 \le m_l/m_s \le 2/5, where the smallest light quark mass value corresponds to a pseudo-scalar Goldstone mass of about 75 MeV. All calculations are performed with staggered fermions on lattices with temporal extent Nt=4. We show that numerical results are consistent with O(N) scaling in the chiral limit. We find that in the region of physical light quark mass values, m_l/m_s \simeq 1/20, the temperature and quark mass dependence of the chiral condensate is already dominated by universal properties of QCD that are encoded in the scaling function for the chiral order parameter, the magnetic equation of state. We also provide evidence for the influence of thermal fluctuations of Goldstone modes on the chiral condensate at finite temperature. At temperatures below, but close to the chiral phase transition at vanishing quark mass, this leads to a characteristic dependence of the light quark chiral condensate on the square root of the light quark mass.Comment: 18 pages, 18 EPS-file

Molecular dynamics of folding of secondary structures in Go-type models of proteins

We consider six different secondary structures of proteins and construct two types of Go-type off-lattice models: with the steric constraints and without. The basic aminoacid-aminoacid potential is Lennard Jones for the native contacts and a soft repulsion for the non-native contacts. The interactions are chosen to make the target secondary structure be the native state of the system. We provide a thorough equilibrium and kinetic characterization of the sequences through the molecular dynamics simulations with the Langevin noise. Models with the steric constraints are found to be better folders and to be more stable, especially in the case of the $\beta$-structures. Phononic spectra for vibrations around the native states have low frequency gaps that correlate with the thermodynamic stability. Folding of the secondary structures proceeds through a well defined sequence of events. For instance, $\alpha$-helices fold from the ends first. The closer to the native state, the faster establishment of the contacts. Increasing the system size deteriorates the folding characteristics. We study the folding times as a function of viscous friction and find a regime of moderate friction with the linear dependence. We also consider folding when one end of a structure is pinned which imitates instantaneous conditions when a protein is being synthesized. We find that, under such circumstances, folding of helices is faster and of the $\beta$-sequences slower.Comment: REVTeX, 14 pages, EPS figures included, JCP in pres

Current Care and Investigational Therapies in Achondroplasia.

The goal of this review is to evaluate the management options for achondroplasia, the most common non-lethal skeletal dysplasia. This disease is characterized by short stature and a variety of complications, some of which can be quite severe. Despite several attempts to standardize care, there is still no widely accepted consensus. This is in part due to absence of concrete data on the incidence of sudden unexplained death in infants with achondroplasia and the best investigation for ascertaining which individuals could benefit from foramen magnum decompression surgery. In this review, we identify the different options of care and management for the various orthopedic, neurologic, and respiratory complications. In parallel, several innovative or drug repositioning therapies are being investigated that would restore bone growth but may also prevent complications. Achondroplasia is the most common non-lethal skeletal dysplasia. It is characterized by short stature and a variety of complications, some of which can be quite severe. Despite several attempts to standardize care, there is still no widely accepted consensus. This is in part due to absence of concrete data on the incidence of sudden unexplained death in infants with achondroplasia and the best investigation for ascertaining which individuals could benefit from foramen magnum decompression surgery. In this review, we identify the different options of care and management for the various orthopedic, neurologic, and respiratory complications. In parallel, several innovative or drug repositioning therapies are being investigated that would restore bone growth but may also prevent complications