Leucotrichoic acid, a novel sesquiterpene from Sinningia leucotricha (Gesneriaceae)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Chemical investigation of Sinningia leucotricha (Gesneriaceae) resulted in the isolation of leucotrichoic acid, a sesquiterpene with a novel triquinane skeleton, and the known triterpenes hederagenin and 23-hydroxyursolic acid. The chemical structures of all compounds were elucidated through spectroscopic analysis (NMR and MS). The conformational stability of the new compound was analyzed by density theory functional methods. A possible biogenesis for the new compound is proposed. Leucotrichoic acid was inactive against a panel of human cancer cell lines. (C) 2013 Elsevier Ltd. All rights reserved.543547354737Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)CNPq [462392/2011-5