Fibrinogen E fragment selectively disrupts the vasculature and inhibits the growth of tumours in a syngeneic murine model

We recently demonstrated that a fragment of human fibrinogen, fibrinogen E fragment, inhibits the migration and differentiation of human endothelial cells in vitro. Here we show that it exerts similar effects on murine endothelial cells in vitro, and selectively disrupts tumour endothelium in vivo, causing widespread intravascular thrombosis and retarding the growth of CT26 tumours in a syngeneic murine model

PATOLOGI : UMUM DAN SISTEMATIK

xii, 647 hlm. ; 21 x 27 c

Patologi

xii;ill.;647hal.;27c

Patologi Umum Dan Sistematik

i-17 hal.; ill.; 26c

Patologi umum dan Sistematik

xii,647 hlm

Patologi

xii;ill.;351hal.;27c

Patologi : umum dan sistematik (general and systematic pathology)

Vol. 1xii, 351 p. : il.; 27 cm