3 research outputs found
Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry
- Author
- Abdelsayed A.A. (Abeer Abeer)
- Acosta A. (Adriana)
- Adams H. (Heath)
- Agostinho J. (João)
- Agostoni P. (Piergiuseppe)
- Airò E. (Edoardo)
- Al Dalaan A. (Abdullah)
- Alexandre M. (Myriam)
- Alexeeva D.E. (Dalyana Eduardovna)
- Alfetlawi M. (Monthir)
- Almagro R.M. (Raúl Menor)
- Alonso L.P. (Lecue Pilar)
- Altraja A. (Alan)
- Andreassen A.K. (Arne K.)
- Anton L. (Ly)
- Argiento P. (Paola)
- Arjona J.J. (Josefa Jiménez)
- Asencio I. (Isabel)
- Atas H. (Halil)
- Avdeev S.N. (Sergey Nikolaevich)
- Avilés F.F. (Francisco Fernandez)
- Badagliacca R. (Roberto)
- Baptista R. (Rui)
- Barberá J.A. (Joan A.)
- Barry L. (Lisa)
- Bartfay S.-E. (Sven-Erik)
- Batalina M.V. (Marina Vadimovna)
- Bauleo C. (Carolina)
- Blanco I. (Isabel)
- Bohacekova M. (Marcela)
- Boogaard H. (H.)
- Boomars K.A.T. (Karin)
- Boonstra A. (Anco)
- Bosio M. (Martin)
- Bruno N. (Noemi)
- Bukatova I.F. (Irina Fedorovna)
- Camacho R.C. (Rafael Conde)
- Campo F. (Felipe)
- Caneva J. (Jorge)
- Capinha M. (Marta)
- Cardoso T. (Tania)
- Castro G. (Graça)
- Cheng C.-C. (Chin-Chang)
- Chu C.Y. (Chun Yuan)
- Church C. (Colin)
- Cifrián Martínez J.M. (José Manuel)
- Conte L. (Luca)
- Correra A. (Anna)
- Corris P. (Paul)
- Costa S. (Serena)
- Cottin V. (Vincent)
- Coutinho D. (Daniel)
- Cresci C. (Chiara)
- Cuesta V.M. (Victor Mora)
- Cárdenas S.L. (Salvador López)
- D'Alto M. (Michele)
- D'Armini A.M. (Andrea Maria)
- De La Pava S. (Sebastian)
- De Luca A. (Anna)
- De Pauw M. (Michel)
- Delcroix M. (Marion)
- Deleo S. (Sabino)
- Di Marco G.M. (Giovanni Maria)
- Diez M. (Mirta)
- Dwyer N. (Nathan)
- Egenlauf B. (Benjamin)
- Elias T. (Teresa)
- Escribano Subías P. (Pilar)
- Espinha M. (Mafalda)
- Evrard P. (Patrick)
- Ewert R. (Ralf)
- Fanaridis M. (Michail)
- Farina S. (Stefania)
- Farkasova I. (Iveta)
- Farruggio S. (Silvia)
- Feenstra J. (John)
- Feistmantl L.-T. (Lisa-Theresa)
- Fernandez D.I. (David Iturbe)
- Filippov E.V. (Evgeny Vladimirovich)
- Fong M.-C. (Man-Cai)
- Gaine S. (Sean)
- Galgano G. (Giuseppe)
- Gall H. (Henning)
- Galyavich A.S. (Albert Sarvatovich)
- Garcea A. (Alessio)
- Garcia A. (Alberto)
- Garcia P. (Paula)
- García S.A. (Salvador Alcaraz)
- Gasche-Soccal P. (Paola)
- Georgopoulos D. (Dimitrios)
- Gerhardt F. (Felix)
- Ghofrani H.A.
- Giannakoulas G. (George)
- Gomez Sanchez M.-A. (Miguel-Angel)
- Gomez J.E. (Juan Esteban)
- Grazioli V. (Valentina)
- Grimminger J. (Jan)
- Gruenberger M. (Margarethe)
- Grünig E. (Ekkehard)
- Guiot J. (Julien)
- Halank M. (Michael)
- Hanta I. (Ismail)
- Harbaum L. (Lars)
- Hegya D.V. (Daria Viktorovna)
- Helmersen D.S. (Douglas S.)
- Ho W.-J. (Wan-Jing)
- Hoeper M.M. (Marius M.)
- Hsu C.-H. (Chih-Hsin)
- Hsu P.-C. (Po-Chao)
- Hsu T.-S. (Tsu-Shiu)
- Huang C.-L. (Chien-Lung)
- Huang W.-C. (Wei-Chun)
- Huang W.-P. (Wen-Pin)
- Huber C. (Charlotte)
- Humbert M.
- Hung C.-S. (Chi-Sheng)
- Ivanov K.I. (Kyundyul Ivanovich)
- Jansa P. (Pavel)
- Jara L. (Luis)
- Karvounis H.I.
- Keogh A. (Anne)
- Klose H. (Hans)
- Klotsche J. (Jens)
- Knoop-Busch S. (Susanne)
- Kolomeytseva T.M. (Tatyana Mikhaylovna)
- Konstantinides S. (Stavros)
- Kotlyar E. (Eugene)
- Kotsia A. (Anna)
- Kramer T. (Tilmann)
- Kulka C. (Christine)
- Kuo P.-H. (Ping-Hung)
- Kuo S.-H. (Shu-Hung)
- Lador F. (Frédéric)
- Lai W.-T. (Wen-Ter)
- Lang I. (Irene)
- Lange T.J. (Tobias J.)
- Langleben D. (David)
- Lavender M. (Melanie)
- Lema C. (Camila)
- Lin J.-L. (Jiunn-Lee)
- Lin T.-H. (Tsung-Hsien)
- Lin Y.-H. (Yen-Hung)
- Lombardi F. (Francesco)
- Londoño A. (Alejandro)
- Lopez M. (Manuel)
- Lopez R. (Raquel)
- Louis R. (Renaud)
- Loureiro M.J. (Maria José)
- Lunardi C. (Claudio)
- Löffler-Ragg J. (Judith)
- Mackenzie M. (Michele)
- Mager J. (J.)
- Maldonado L. (Lorena)
- Manzi G. (Giovanna)
- Marinho A. (António)
- Marrero F.L. (Fernando León)
- Martinez W. (William)
- Martinez-Meñaca A. (Amaya)
- Martins Jesus S.M. (Susana Maria)
- Martynyuk T.V. (Tamila Vitalievna)
- Massola G. (Giulia)
- Mehta S. (Sanjay)
- Meier C. (Christian)
- Melatini L. (Luciano)
- Mellemkjaer S. (Soren)
- Michalis L.K. (Lampros)
- Mielniczuk L.M. (Lisa M.)
- Minson R. (Robert)
- Mitrouska I. (Ioanna)
- Mouratoglou S. (Sofia)
- Mulè M. (Massimiliano)
- Mutlu B. (Bülent)
- Naldi M. (Marco)
- Ndreu R. (Rudina)
- Newnham M. (Michael)
- Ng B. (Benjamin)
- Nielsen-Kudsk J.E. (Jens Erik)
- Nikolaevich B.A. (Bykov Aleksander)
- Nolde A. (Anna)
- Noël-Savina E. (Elise)
- Okumus G. (Gulfer)
- Oliveira A. (Ana)
- Olzik I. (Ilona)
- Ongen G. (Gul)
- Oqueka T. (Tim)
- Orozco-Levi M. (Mauricio)
- Otero R. (Remedios)
- Paciocco G. (Giuseppe)
- Pane F. (Federico)
- Pappas A. (Athanasios)
- Pappas K. (Konstantinos)
- Pavlickova I. (Ivana)
- Pavlova O.B. (Olga Borisovna)
- Peacock A. (Andrew)
- Pepke-Zaba J. (Joanna)
- Pesci A. (Alberto)
- Petruzzi M. (Mario)
- Peñate G.P. (Gregorio Pérez)
- Picariello C. (Claudio)
- Piccari L. (Lucilla)
- Pin M. (Maurizio)
- Pitsiou G. (Georgia)
- Pittrow D. (David)
- Platonov D.Y. (Dmitry Yurievich)
- Poscia R. (Roberto)
- Prediletto R. (Renato)
- Proudman S. (Susanna)
- Quezada C.A. (Carlos Andres)
- Reesink H.J. (Herre)
- Reeves G. (Glenn)
- Regotta S. (Sabine)
- Repolho D. (Débora)
- Rocha A. (Andreia)
- Rochat T. (Thierry)
- Rodríguez P.V. (Patricia Villanueva)
- Roman A. (Antonio)
- Roncon L. (Loris)
- Rosenkranz S. (Stephan)
- Rozas S.F. (Sonia Fernandez)
- Rundqvist B. (Bengt)
- Sadushi-Kolici R. (Roela)
- Sakkijha H. (Hussam)
- Saleemi S. (Sarferaz)
- Sardella L. (Luca)
- Schulz C. (Christian)
- Schwarz E.I. (Esther Irene)
- Sciortino A. (Antonio)
- Sebastian L. (Laura)
- Shearman N. (Nicole)
- Shiang T. (Teresa)
- Simon M. (Marcel)
- Simonneau G. (Gérald)
- Sitbon O. (Olivier)
- Skripkina E.S. (Elena Sergeevna)
- Snijder R.
- Sourla E. (Evdokia)
- Sousa J. (Joana)
- Speich R. (Rudolf)
- Stanopoulos I. (Ioannis)
- Steele P. (Peter)
- Steringer-Mascherbauer R. (Regina)
- Stevens W. (Wendy)
- Su H.-M. (Ho-Ming)
- Sung S.-H. (Shih-Hsien)
- Söderberg S. (Stefan)
- Talavera M.L. (Maria Lujan)
- Tania G. (Gonçalves)
- Tayler S. (Susanne)
- Tilea I. (Ioana)
- Toorn L.M. (Leon) van den
- Torricelli E. (Elena)
- Toshner M. (Mark)
- Tovar P.P. (Patricia Parada)
- Tregubova A.V. (Anna Viktorovna)
- Tsangaris I. (Iraklis)
- Tsareva N.A. (Natalia Anatolievna)
- Tuhay G. (Graciela)
- Têtu L. (Laurent)
- Ulrich S. (Silvia)
- Un Z. (Zeynep)
- Vachiéry J.-L. (Jean-Luc)
- Valkovicova T. (Tatiana)
- Vannucchi V. (Vieri)
- Vasankari T. (Tuija)
- Vihinen T. (Tapani)
- Vizza C.D. (Carmine Dario)
- Vonk Noordegraaf A. (Anton)
- Voon W.-C. (Wen-Chol)
- Vulcano N. (Norberto)
- Wang W.-H. (Wen-Hwa)
- Weheba I. (Ihab)
- Williams E. (Evgenia)
- Wirtz G. (Gil)
- Wirtz H. (Hubert)
- Wodlin P. (Peter)
- Wu C.-K. (Cho-Kai)
- Wu S.-H. (Shu-Hao)
- Yakovleva O.E. (Olga Eduardovna)
- Yen H.-W. (Hsueh-Wei)
- Yih-Jer Wu J. (Jacob)
- Yotti R. (Raquel)
- Zvereva T.N. (Tatyana Nikolaevna)
- Šimková I. (Iveta)
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/03/2021
- Field of study
Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase
Recommended from our members
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
- Author
- Asarnow Daniel
- Azumaya Caleigh M
- Barrio-Hernandez Inigo
- Batra Jyoti
- Biel Justin
- Billesbølle Christian
- Bouhaddou Mehdi
- Bowen Alisa
- Braberg Hannes
- Braxton Julian R
- Brilot Axel F
- Burke David
- Cakir Merve
- Cakir Zeynep
- Campbell Melody G
- Chen Jen
- Chio Cynthia M
- Chio Un Seng
- Deshpande Ishan
- Diallo Amy
- Dickinson Miles Sasha
- Diwanji Devan
- Doan Loan
- Dunham Alistair
- Eckhardt Manon
- Fabius Jacqueline M
- Faust Bryan
- Flores Sebastian
- Foussard Helene
- Gordon David E
- Guo Jeffrey Z
- Gupta Meghna
- Haas Kelsey M
- Haas Paige
- Herrera Nadia
- Hiatt Joseph
- Hoppe Nick
- Hüttenhain Ruth
- Jang Gwendolyn
- Jin Mingliang
- Jureka Alexander S
- Kaake Robyn M
- Kim Kate
- Koh Cassandra
- Kratochvil Huong T
- Kuchenov Dmitry
- Lam Victor L
- Li Fei
- Li Junrui
- Li Yang
- Li Yen-Li
- Liu Xi
- Liu Yanxin
- Lo Megan
- Lopez Kyle E
- Marrero Miguel Correa
- McGregor Michael
- Melo Arthur A
- Memon Danish
- Merz Gregory E
- Modak Maya
- Moritz Michelle
- Moss Frank R
- Naing Zun Zar Chi
- Nguyen Henry C
- Nguyen Phuong
- Nowotny Carlos
- O'Meara Matthew J
- Obernier Kirsten
- Owens Tristan W
- Paulino Joana
- Pawar Komal Ishwar
- Peters Jessica K
- Petsalaki Eirini
- Pourmal Sergei
- Puchades Cristina
- Pulido Ernst H
- Rathore Ujjwal
- Rezelj Veronica V
- Rizo Alexandrea N
- Rojc Ajda
- Schulze-Gahmen Ursula
- Shi Ying
- Silvas Jesus A
- Smith Amber M
- Soucheray Margaret
- Sun Ming
- Swaney Danielle L
- Titus Erron W
- Tummino Tia A
- Tutuncuoglu Beril
- Ulferts Svenja
- Ummadi Manisha
- Vallet Thomas
- Weckstein Andrew R
- Xu Jiewei
- Young Iris D
- Zhang Ziyang
- Zhao Jianhua
- Zhou Yuan
- Publication venue
- eScholarship, University of California
- Publication date
- 01/12/2020
- Field of study
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
- Author
- Abate Carmen
- Agard David A.
- Agard David A.
- Alessi Dario R.
- Asarnow Daniel
- Asarnow Daniel
- Azumaya Caleigh M.
- Azumaya Caleigh M.
- Baillie Carla
- Barrio-Hernandez Inigo
- Basler Christopher F.
- Batra Jyoti
- Beltrao Pedro
- Berardi Francesco
- Biel Justin
- Biel Justin
- Billesbølle Christian
- Billesbølle Christian
- Bouhaddou Mehdi
- Bowen Alisa
- Bowen Alisa
- Braberg Hannes
- Braxton Julian R.
- Braxton Julian R.
- Brilot Axel F.
- Brilot Axel F.
- Brown Fiona
- Burke David
- Burness Kerry A.
- Cakir Merve
- Cakir Zeynep
- Campbell Melody G.
- Campbell Melody G.
- Carlson-Stevermer Jared
- Chauhan Gaurav
- Chazal Maxime
- Chen Jen
- Chen Jen
- Cheng Yifan
- Cheng Yifan
- Chio Cynthia M.
- Chio Cynthia M.
- Chio Un Seng
- Chio Un Seng
- Corbo Marco
- Damas Joana
- Davies Paul
- Deshpande Ishan
- Deshpande Ishan
- Diallo Amy
- Diallo Amy
- Dickinson Miles Sasha
- Dickinson Miles Sasha
- Diwanji Devan
- Diwanji Devan
- Doan Loan
- Doan Loan
- Dong Michael
- Dorward Mark
- Dunham Alistair
- Dunham Ian
- Eckhardt Manon
- Elliott Matthew
- Fabius Jacqueline M.
- Faust Bryan
- Faust Bryan
- Flores Sebastian
- Flores Sebastian
- Foussard Helene
- Fozouni Parinaz
- Fraser James S.
- Fraser James S.
- Frieman Matthew B.
- Frost Adam
- Frost Adam
- García-Sastre Adolfo
- Genereux Diane P.
- Geyer Anna
- Ghoussaini Maya
- Giesel Daniel M.
- Goodman Nicola
- Gordon David E.
- Grosse Robert
- Guo Jeffrey Z.
- Gupta Meghna
- Gupta Meghna
- Haas Kelsey M.
- Haas Paige
- Hastie C. James
- Haupt Robert
- Hemphill Kafi R.
- Herrera Nadia
- Herrera Nadia
- Hiatt Joseph
- Hiller Michael
- Hodder Anthony J.
- Holden Kevin
- Hoppe Nick
- Hoppe Nick
- Hughes Graham M.
- Hüttenhain Ruth
- Ideker Trey
- Jang Gwendolyn
- Jin Mingliang
- Jin Mingliang
- Johnson Clare
- Jouvenet Nolwenn
- Jura Natalia
- Jura Natalia
- Jureka Alexander S.
- Kaake Robyn M.
- Kaplow Irene
- Karim Mohd Anisul
- Karlsson Elinor K.
- Kehrer Thomas
- Keough Kathleen C.
- Keough Kathleen C.
- Khalid Mir M.
- Kim Kate
- Kim Kate
- Kirilenko Bodgan
- Klesh Reyna J.
- Kochs Georg
- Koepfli Klaus-Peter
- Koh Cassandra
- Kortemme Tanja
- Kortemme Tanja
- Kratochvil Huong T.
- Kratochvil Huong T.
- Krogan Nevan J.
- Kuchenov Dmitry
- Lam Victor L.
- Lam Victor L.
- Leech Hannah
- Lewin Harris A.
- Li Fei
- Li Fei
- Li Junrui
- Li Junrui
- Li Shirley Xue
- Li Yang
- Li Yang
- Li Yen-Li
- Li Yen-Li
- Lind Abigail
- Lind Abigail L.
- Lindblad-Toh Kerstin
- Liu Xi
- Liu Xi
- Liu Yanxin
- Liu Yanxin
- Lo Megan
- Lo Megan
- Logue James
- Lopez Kyle E.
- Lopez Kyle E.
- Manglik Aashish
- Manglik Aashish
- Marinescu Vikki
- Marrero Miguel Correa
- Maures Travis
- McGrath Marisa
- McGregor Michael
- Meadows Jennifer
- Melo Arthur A.
- Melo Arthur A.
- Memon Danish
- Merz Gregory E.
- Merz Gregory E.
- Miorin Lisa
- Modak Maya
- Moreno Elena
- Moritz Michelle
- Moritz Michelle
- Moss Frank R.
- Moss Frank R.
- Naing Zun Zar Chi
- Nguyen Henry C.
- Nguyen Henry C.
- Nguyen Phuong
- Nguyen Phuong
- Nowotny Carlos
- Nowotny Carlos
- Nweeia Martin T.
- Obernier Kirsten
- Oki Jennifer
- Ott Melanie
- Owens Tristan W.
- Owens Tristan W.
- O’Meara Matthew J.
- Painter Corrie A.
- Palmarini Massimo
- Park Jisoo
- Patel Arvind H.
- Paulino Joana
- Paulino Joana
- Pawar Komal Ishwar
- Pawar Komal Ishwar
- Peden Andrew A.
- Persky Nicole S.
- Peters Jessica K.
- Peters Jessica K.
- Petsalaki Eirini
- Pfenning Andreas R.
- Pollard Katherine S.
- Pollard Katherine S.
- Pospiech Thomas H.
- Pospiech Thomas H.
- Pourmal Sergei
- Pourmal Sergei
- Power Sarahjane
- Puchades Cristina
- Puchades Cristina
- Pulido Ernst H.
- Raggett Samantha
- Rassen Jeremy A.
- Rathore Ujjwal
- Ray David A.
- Reid Elaine
- Rezelj Veronica V.
- Rihn Suzannah
- Rizo Alexandrea N.
- Rizo Alexandrea N.
- Rojc Ajda
- Rosales Romel
- Rosenberg Oren S.
- Rosenberg Oren S.
- Roth Theodore L.
- Ryderq Oliver A.
- Safari Maliheh
- Safari Maliheh
- Sali Andrej
- Saltzberg Daniel
- Sangwan Smriti
- Sangwan Smriti
- Schaefer Kaitlin
- Schaefer Kaitlin
- Schulze-Gahmen Ursula
- Schulze-Gahmen Ursula
- Shi Ying
- Shoichet Brian
- Shokat Kevan M.
- Shun-Shion Amber S.
- Silvas Jesus A.
- Simoneau Camille R.
- Smith Amber M.
- Smith Amber M.
- Soucheray Margaret
- Southworth Daniel R.
- Southworth Daniel R.
- Stroud Robert M.
- Stroud Robert M.
- Sun Ming
- Sun Ming
- Swaney Danielle L.
- Swofford Ross
- Teeling Emma C.
- Thomas Paul V.
- Thomas Paul V.
- Thwin Aye C.
- Thwin Aye C.
- Titus Erron W.
- Titus Erron W.
- Toth Rachel
- Trenker Raphael
- Trenker Raphael
- Trinidad Donovan
- Tse Eric
- Tse Eric
- Tsui Tsz Kin Martin
- Tsui Tsz Kin Martin
- Tummino Tia A.
- Tutuncuoglu Beril
- Ulferts Svenja
- Ummadi Manisha
- Vallejo-Gracia Albert
- Vallet Thomas
- Verba Kliment A.
- Verba Kliment A.
- Vignuzzi Marco
- Wallerman Ola
- Wang Feng
- Wang Feng
- Weckstein Andrew R.
- Weigang Sebastian
- Weston Stuart
- White Kris M.
- Whitis Natalie
- Whitis Natalie
- Wilkinson Stuart G.
- Williams Daniel M.
- Wirthlin Morgan
- Wu David
- Xu Jiewei
- Young Iris D.
- Young Iris D.
- Yu Zanlin
- Yu Zanlin
- Zhang Kaihua
- Zhang Kaihua
- Zhang Yang
- Zhang Yang
- Zhang Ziyang
- Zhao Huabin
- Zhao Jianhua
- Zhao Jianhua
- Zhou Fengbo
- Zhou Fengbo
- Zhou Yuan
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
International audienc