トクシマ ダイガク シラギクカイ ノ カツドウ ト コンゴ ノ ホウコウセイ

Shiragiku-kai, established in 1967, is a nonprofit organization whose members are individually registered for the willed body donation program at Tokushima University. Main activities of Shiragiku-kai include returning the remains after studies are complete, holding annual memorial services of donors, and organizing general and district assembly meetings. Currently, twelve clinical departments are conducting surgical training and clinical research in the Clinical Anatomy Laboratory utilizing donations. To meet the ongoing need for donations, it is essential to promote greater understanding among the general public and increase the number of registered members for this valuable program

Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth : Involvement of protein kinase C-θ activation

Associations between growth factor receptor-mediated cell signaling and cancer cell growth have been previously characterized. Receptors for prostaglandin E2, such as EP2, and EP4, play roles in cancer growth, progression and invasion. Thus, we examined the interactions between EP2/EP4- and IGF-1R-mediated cellular signaling in human pancreatic cancer cells. Selective antagonists against EP2 and EP4 abrogated IGF-1-stimulated cell growth and suppressed MEK/ERK phosphorylation. In subsequent experiments, phospho-antibody arrays indicated increased phosphorylation levels of protein kinase C-θ (PKC-θ) at the Thr538 position following the inhibition of EP2/EP4-mediated signaling. Inhibition of PKC-θ activity impaired cell viability compared with EP2/EP4-antagonized IGF-1-stimulated cells. PKC-θ kinase MAP4K3, which plays a pivotal role in PKC-θ activation, also affected growth signaling in the presence of EP2/EP4 antagonists. Administration of EP2 and EP4 antagonists significantly inhibited the growth of an orthotopic xenograft of IGF-1-secreting pancreatic cancer cells, with increased phospho-PKC-θ and decreased phospho-ERK. Clinico-pathological analyses showed that 17.4% of surgical pancreatic cancer specimens were quadruple-positive for IGF-1R, EP2 (or EP4), MAP4K3, and PKC-θ. These results indicate a novel signaling crosstalk between EP2/EP4 and IGF-1R in cancer cells, and suggest that the MAP4K3-PKC-θ axis is central and could be exploited as a molecular target for cancer therapy

A case of complete decapitation

Complete decapitation due to suicide by hanging is rare. We report the case of a decapitated man who was found in the sea near an estuary. A polyethylene rope was tied to the handrail of the bridge across a strait near the site of the body. The rope was 12 mm in diameter and 19 m in length from the handrail. It ended with a slip knot noose, and skin and mustache-like hair fragments were attached to it. The decapitated head was not found. The deceased weighed 82 kg and was 152 cm long without the head. The autopsy revealed coarse abrasions and intramuscular hemorrhage around the severed edge. The third cervical spine was not fractured. We reviewed the literature and suggested the conditions of body weight, fall height, rope diameter, and number of rolls in cases of decapitation by hanging. We calculated the hanging decapitation index (HDI) as the fall height (m) multiplied by the body weight (kg), divided by the rope diameter (mm), divided by the number of rolls ; and discussed the differences between complete and incomplete decapitation cases

SiO Emission in the Multi-Lobe Outflow associated with IRAS 16293-2422

We have mapped the thermal emission line of SiO (v = 0; J = 2-1) associated with the quadrupolar molecular outflow driven by the very cold far-infrared source IRAS 16293-2422. The SiO emission is significantly enhanced in the northeastern red lobe and at the position ~50" east of the IRAS source. Strong SiO emission observed at ~50" east of the IRAS source presents evidence for a dynamical interaction between a part of the eastern blue lobe and the dense ambient gas condensation, however, such an interaction is unlikely to be responsible for producing the quadrupolar morphology. The SiO emission in the northeastern red lobe shows the spatial and velocity structure similar to those of the CO outflow, suggesting that the SiO emission comes from the molecular outflow in the northeastern red lobe itself. The observed velocity structure is reproduced by a simple spatio-kinematic model of bow shock with a shock velocity of 19-24 km/s inclined by 30-45 deg from the plane of the sky. This implies that the northeastern red lobe is independent of the eastern blue lobe and that the quadrupolar structure is due to two separate bipolar outflows. The SiO emission observed in the western red lobe has a broad pedestal shape with low intensity. Unlike the SiO emission in the northeastern red lobe, the spatial extent of the SiO emission in the western red lobe is restricted to its central region. The spatial and velocity structures and the line profiles suggest that three different types of the SiO emission are observed in this outflow; the SiO emission arises from the interface between the outflowing gas and the dense ambient gas clump, the SiO emission coming from the outflow lobe itself, and the broad SiO emission with low intensity observed at the central region of the outflow lobe.Comment: 14 pages, 6 figures (figures 1 and 4 are color), gzipped tar file, To appear in the Ap

The ortho-to-para ratio of ammonia in the L1157 outflow

We have measured the ortho-to-para ratio of ammonia in the blueshifted gas of the L1157 outflow by observing the six metastable inversion lines from (J, K) = (1, 1) to (6, 6). The highly excited (5, 5) and (6, 6) lines were first detected in the low-mass star forming regions. The rotational temperature derived from the ratio of four transition lines from (3, 3) to (6, 6) is 130-140 K, suggesting that the blueshifted gas is heated by a factor of ~10 as compared to the quiescent gas. The ortho-to-para ratio of the NH3 molecules in the blueshifted gas is estimated to be 1.3--1.7, which is higher than the statistical equilibrium value. This ratio provides us with evidence that the NH3 molecules have been evaporated from dust grains with the formation temperature between 18 and 25 K. It is most likely that the NH3 molecules on dust grains have been released into the gas phase through the passage of strong shock waves produced by the outflow. Such a scenario is supported by the fact that the ammonia abundance in the blueshifted gas is enhanced by a factor of ~5 with respect to the dense quiescent gas.Comment: 16 pages, including 3 PS figures. To appear in the ApJ (Letters). aastex macro

Effect of coffee or coffee components on gut microbiome and short-chain fatty acids in a mouse model of metabolic syndrome

We previously showed that male Tsumura Suzuki obese diabetes (TSOD) mice, a spontaneous mouse model of metabolic syndrome, manifested gut dysbiosis and subsequent disruption of the type and quantity of plasma short-chain fatty acids (SCFAs), and daily coffee intake prevented nonalcoholic steatohepatitis in this mouse model. Here, we present a preliminary study on whether coffee and its major components, caffeine and chlorogenic acid, would affect the gut dysbiosis and the disrupted plasma SCFA profile of TSOD mice, which could lead to improvement in the liver pathology of these mice. Three mice per group were used. Daily intake of coffee or its components for 16 wk prevented liver lobular inflammation without improving obesity in TSOD mice. Coffee and its components did not repair the altered levels of Gram-positive and Gram-negative bacteria and an increased abundance of Firmicutes in TSOD mice but rather caused additional changes in bacteria in six genera. However, caffeine and chlorogenic acid partially improved the disrupted plasma SCFA profile in TSOD mice, although coffee had no effects. Whether these alterations in the gut microbiome and the plasma SCFA profile might affect the liver pathology of TSOD mice may deserve further investigation

Analysis of the gut microbiome and plasma short-chain fatty acid profiles in a spontaneous mouse model of metabolic syndrome

Male Tsumura Suzuki obese diabetes (TSOD) mice spontaneously develop obesity and obesity-related metabolic syndrome. Gut dysbiosis, an imbalance of gut microbiota, has been implicated in the pathogenesis of metabolic syndrome, but its mechanisms are unknown. Short-chain fatty acids (SCFAs) are the main fermentation products of gut microbiota and a link between the gut microbiota and the host’s physiology. Here, we investigated a correlation among gut dysbiosis, SCFAs, and metabolic syndrome in TSOD mice. We detected enriched levels of Gram-positive bacteria and corresponding decreases in Gram-negative bacteria in 24-wk-old metabolic syndrome-affected TSOD mice compared with age-matched controls. The abundance of Bacteroidetes species decreased, the abundance of Firmicutes species increased, and nine genera of bacteria were altered in 24-wk-old TSOD mice. The total plasma SCFA level was significantly lower in the TSOD mice than in controls. The major plasma SCFA—acetate—decreased in TSOD mice, whereas propionate and butyrate increased. TSOD mice had no minor SCFAs (valerate and hexanoate) but normal mice did. We thus concluded that gut dysbiosis and consequent disruptions in plasma SCFA profiles occurred in metabolic syndrome-affected TSOD mice. We also propose that the TSOD mouse is a useful model to study gut dysbiosis, SCFAs, and metabolic syndrome

コウレイ ジョセイ ノ カイワ ニ ミラレル キョウリョクテキ ナ スタイル

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