Evolution and Nucleosynthesis of Metal-Free Massive Stars

We calculate presupernova evolutions and supernova explosions of massive stars (M=13-25 Mo) for various metallicities. We find the following characteristic abundance patterns of nucleosynthesis in the metal-free (Pop III) stars. (1) The alpha-nuclei (from C to Zn) are more efficiently produced than other isotopes, and the abundance pattern of alpha-nuclei can be similar to the solar abundance. In particular, near solar ratios of alpha elements/Fe might be a signature of Pop III which could produce a large amount of Fe. (2) The abundance ratios of odd Z to even Z elements such as Na/Mg and Al/Mg become smaller for lower metallicity. However, these ratios almost saturate below Z <~ 10^{-5}, and [Na, Al/Mg] ~ - 1 for Pop III and low metal Pop II nucleosynthesis. This result is consistent with abundance pattern of metal poor stars, in which these ratios also saturate around -1. We suggest that these stars with the lowest [Na/Mg] or [Al/Mg] may contain the abundance pattern of Pop III nucleosynthesis. (3) Metal poor stars show interesting trends in the ratios of [Cr, Mn, Co/Fe]. We discuss that these trends are not explained by the differences in metallicity, but by the relative thickness between the complete and the incomplete Si burning layers. Large [Co/Fe] and small [Cr, Mn/Fe] values found in the observations are explained if mass cut is deep or if matter is ejected from complete Si burning layer in a form of a jet or bullets. (4) We also find that primary ^{14}N production occurs in the massive Pop III stars, because these stars have radiative H-rich envelopes so that the convective layer in the He-shell burning region can reach the H-rich region.Comment: 19 pages. To appear in the proceedings of the MPA/ESO conference ``The First Stars'' (August 4-7, 1999, Garching) ed. A. Weiss etal. (Springer

Hypernova Nucleosynthesis and Implications for Cosmic Chemical Evolution

We examine the characteristics of nucleosynthesis in 'hypernovae', i.e., supernovae with very large explosion energies (\gsim 10^{52} ergs). Implications for the cosmic chemical evolution and the abundances in M82 are discussed.Comment: To appear in 'Cosmic Evolution' Conference at IAP, Paris, honoring Jean Audouze and Jim Truran, 13-17 Nov 200

Single Balloon Enteroscopy-Assisted ERCP Using Rendezvous Technique for Sharp Angulation of Roux-en-Y Limb in a Patient with Bile Duct Stones

The acute angulation of Roux-en-Y (R-Y) limb precludes endoscopic access for endoscopic retrograde cholangiopancreatography (ERCP) even using a balloon enteroscopy. Here, we describe a case of successful single balloon enteroscopy (SBE)-assisted ERCP using a rendezvous technique in a patient with sharply angulated R-Y limb in a 79-year-old woman who had bile duct stones. Method. At first, a guidewire was passed antegradely through the major papilla after the needle puncture using percutaneous transhepatic biliary drainage technique. A hydrophilic guidewire with an ERCP catheter was antegradely advanced beyond the Roux limb. After a guidewire was firmly grasped by a snare forceps, it was pulled out of the body, resulting that the enteroscope could advance to the papilla. After papillary dilation, complete removal of bile duct stones was achieved without any procedure-related complication. In conclusion, although further study is needed, SBE-assisted ERCP using a rendezvous technique may have a potential for selected patients

Population-genetic nature of copy number variations in the human genome

Copy number variations (CNVs) are universal genetic variations, and their association with disease has been increasingly recognized. We designed high-density microarrays for CNVs, and detected 3000–4000 CNVs (4–6% of the genomic sequence) per population that included CNVs previously missed because of smaller sizes and residing in segmental duplications. The patterns of CNVs across individuals were surprisingly simple at the kilo-base scale, suggesting the applicability of a simple genetic analysis for these genetic loci. We utilized the probabilistic theory to determine integer copy numbers of CNVs and employed a recently developed phasing tool to estimate the population frequencies of integer copy number alleles and CNV–SNP haplotypes. The results showed a tendency toward a lower frequency of CNV alleles and that most of our CNVs were explained only by zero-, one- and two-copy alleles. Using the estimated population frequencies, we found several CNV regions with exceptionally high population differentiation. Investigation of CNV–SNP linkage disequilibrium (LD) for 500–900 bi- and multi-allelic CNVs per population revealed that previous conflicting reports on bi-allelic LD were unexpectedly consistent and explained by an LD increase correlated with deletion-allele frequencies. Typically, the bi-allelic LD was lower than SNP–SNP LD, whereas the multi-allelic LD was somewhat stronger than the bi-allelic LD. After further investigation of tag SNPs for CNVs, we conclude that the customary tagging strategy for disease association studies can be applicable for common deletion CNVs, but direct interrogation is needed for other types of CNVs

Diffusionless isothermal omega transformation in titanium alloys driven by quenched-in compositional fluctuations

In titanium alloys, the ω(hexagonal)-phase transformation has been categorized as either a diffusion-mediated isothermal transformation or an athermal transformation that occurs spontaneously via a diffusionless mechanism. Here we report a diffusionless isothermal ω transformation that can occur even above the ω transformation temperature. In body-centered cubic β-titanium alloyed with β-stabilizing elements, there are locally unstable regions having fewer β-stabilizing elements owing to quenched-in compositional fluctuations that are inevitably present in thermal equilibrium. In these locally unstable regions, diffusionless isothermal ω transformation occurs even when the entire β region is stable on average so that athermal ω transformation cannot occur. This anomalous, localized transformation originates from the fluctuation-driven localized softening of 2/3[111]β longitudinal phonon, which cannot be suppressed by the stabilization of β phase on average. In the diffusionless isothermal and athermal ω transformations, the transformation rate is dominated by two activation processes: a dynamical collapse of {111}β pairs, caused by the phonon softening, and a nucleation process. In the diffusionless isothermal transformation, the ω-phase nucleation, resulting from the localized phonon softening, requires relatively high activation energy owing to the coherent β/ω interface. Thus, the transformation occurs at slower rates than the athermal transformation, which occurs by the widely spread phonon softening. Consequently, the nucleation probability reflecting the β/ω interface energy is the rate-determining process in the diffusionless ω transformations.Tane M., Nishiyama H., Umeda A., et al. Diffusionless isothermal omega transformation in titanium alloys driven by quenched-in compositional fluctuations. Physical Review Materials 3, 043604 (2019); https://doi.org/10.1103/PhysRevMaterials.3.043604

Nucleosynthesis in Type II supernovae and the abundances in metal-poor stars

We explore the effects on nucleosynthesis in Type II supernovae of various parameters (mass cut, neutron excess, explosion energy, progenitor mass) in order to explain the observed trends of the iron-peak element abundance ratios ([Cr/Fe], [Mn/Fe], [Co/Fe] and [Ni/Fe]) in halo stars as a function of metallicity for the range $-4 \le$ [Fe/H] $\le -2.5$. [Cr/Fe] and [Mn/Fe] decrease with decreasing [Fe/H], while [Co/Fe] behaves the opposite way and increases. We show that such a behavior can be explained by a variation of mass cuts in Type II supernovae as a function of progenitor mass, which provides a changing mix of nucleosynthesis from an alpha-rich freeze-out of Si-burning and incomplete Si-burning. This explanation is consistent with the amount of ejected $^{56}$Ni determined from modeling the early light curves of individual supernovae. We also suggest that the ratio [H/Fe] of halo stars is mainly determined by the mass of interstellar hydrogen mixed with the ejecta of a single supernova which is larger for larger explosion energy and the larger Str\"omgren radius of the progenitor.Comment: 17 pages, LaTeX, Accepted for publication in the Astrophysical Journal, more discussion on the Galactic chemical evolutio

Effect of Nanosheet Surface Structure of Titanium Alloys on Cell Differentiation

Titanium alloys are the most frequently used dental implants partly because of the protective oxide coating that spontaneously forms on their surface. We fabricated titania nanosheet (TNS) structures on titanium surfaces by NaOH treatment to improve bone differentiation on titanium alloy implants. The cellular response to TNSs on Ti6Al4V alloy was investigated, and the ability of the modified surfaces to affect osteogenic differentiation of rat bone marrow cells and increase the success rate of titanium implants was evaluated. The nanoscale network structures formed by alkali etching markedly enhanced the functions of cell adhesion and osteogenesis-related gene expression of rat bone marrow cells. Other cell behaviors, such as proliferation, alkaline phosphatase activity, osteocalcin deposition, and mineralization, were also markedly increased in TNS-modified Ti6Al4V. Our results suggest that titanium implants modified with nanostructures promote osteogenic differentiation, which may improve the biointegration of these implants into the alveolar bone

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection