1-(Pyridin-2-yl)-2-[2-(trifluoro­meth­yl)benz­yl]-3-[2-(trifluoro­meth­yl)phen­yl]propan-1-one

The title compound, C23H17F6NO, crystallizes with two mol­ecules in the asymmetric unit. The mol­ecules assume an approximate propellar shape, with the three aromatic rings being bent with respect to the plane formed by the C atoms that are connected to the methine C atom [dihedral angles: pyridyl 67.49 (3)°, phenyl 56.82 (4)° and phenyl 77.21 (6)° in one mol­ecule, and corresponding angles of 71.60 (6), 53.68 (4) and 77.53 (6)° in the second mol­ecule]

2-Benzyl-3-phenyl-1-(pyridin-2-yl)propan-1-one

Mol­ecules of the title compound, C21H19NO, assume an approximate propellar shape, with the three aromatic rings being nearly perpendicularly aligned with respect to the plane formed by the C atoms that are connected to the methine C atom [dihedral angles: pyridyl 79.82 (4)°, phenyl 80.12 (3)° and phenyl 86.93 (3)°]

Revolutionizing Islamic Finance: The Impact of Islamic Banks on Car Ijarah Financing in Pakistan

Pakistan is one of the countries that has contributed significantly to Islamic Banking and Finance growth. During the past few years, the Islamic financial sector has experienced significant growth, with an annual growth rate of over 31%. Currently, Pakistan's Islamic banking sector holds almost 11% of market share (SBP: Strategic Strategy for Islamic Banking Sector of Pakistan 2019-2023). The most popular form of Islamic financing is Car Ijarah financing, which accounted for 8.6% of overall financing from the beginning of the year until December 2022 (SPB-IBB-Dec 2022). Pakistan had five full-fledged Islamic banks as of December 31, 2022, as well as 561 Islamic financial divisions in conventional banks (Islamic Banking Strategy and Guidelines Division, SBP). This study analyzes the development of Ijarah financing. Thus, for their contextual research, experts selected Meezan Bank, the largest Islamic bank in the world. An independent variable is Car Ijarah Security Deposit (CISD), Car Ijarah Charities (CJC), Car Ijarah Inventories (CII), while a dependent variable is Net Car Ijarah Financing (NCJF). During the extended period from (2019–2023), data are derived from Islamic banks' financial statements (secondary source). As a result, each coefficient's size is indicated. Using the coefficients, Meezan Bank's net Ijarah financing was estimated. Meezan Bank's size had a significant impact on its net Ijarah financing, suggesting that it had a substantial impact on the bank's success

Comparison of Tzanakis and Alvarado scoring system in diagnosis of acute appendicitis, with Histopathology as gold standard

Objective: To determine the diagnostic accuracy of Tzanakis and Alvarado score for the diagnosis of acute appendicitis taking histopathology as the gold standard. Materials and Methods: It was a Cross-sectional validation study The study was carried out at the emergency department of RMC allied hospital Rawalpindi. The study was completed in eighteen months from 1st May 2016 till 30th Nov 2017. After approval from the ethical committee total of 420 patients fulfilling inclusion criteria from the emergency department of District head Quarter hospital, Rawalpindi was taken. Informed consent was taken from patients or their attendants, and their demographic information like name, age, sex, and address was obtained. Alvarado score and Tzanakis score were calculated (as per operational definition) at the time of admission of the patients. After surgery, the specimen appendix was sent for histopathology in the hospital lab.  The diagnosis of the acute appendix was based on a positive histological report which was verified by a pathologist. All the data was entered by a researcher who will collect the data by himself. Results: The mean age of patients in this study was 20.15±7.13 years with 218 (51.9%) males and 202 (48.1%) females. The mean Alvardo score was recorded as 7.22±1.58 with the mean Tzanakis score being 9.64±3.13. The histopathology for diagnosing appendicitis showed positive for 367 (87.4%) patients and negative for 53 (12.6%) patients. The sensitivity of Alvarado score for diagnosing appendicitis, keeping histopathology as the gold standard was 86.92%, specificity was 92.45%, Positive Predictive Value was 98.76%, and Negative Predictive Value was 50.52% and overall diagnostic accuracy was 87.62%. The sensitivity of the Tzanakis score for diagnosing appendicitis, keeping histopathology as the gold standard was 88.83%, specificity was 88.6%, Positive Predictive Value was 98.19%, Negative Predictive Value was 53.41% and overall diagnostic accuracy was 88.81%. Conclusion: The sensitivity of the Tzanakis score was high when compared to the Alvarado score. And specificity was high in the Alvarado score when compared to the Tzanakis score. Moreover, the overall diagnostic accuracy of the Tzanakis score was high when compared to the Alvarado score. SoTzanakis score can be utilized to predict appendix and in the future, we can avoid negative appendectomies

Comparison of Tzanakis and Alvarado scoring system in diagnosis of acute appendicitis, with Histopathology as gold standard

Objective: To determine the diagnostic accuracy of Tzanakis and Alvarado score for the diagnosis of acute appendicitis taking histopathology as the gold standard. Materials and Methods: It was a Cross-sectional validation study The study was carried out at the emergency department of RMC allied hospital Rawalpindi. The study was completed in eighteen months from 1st May 2016 till 30th Nov 2017. After approval from the ethical committee total of 420 patients fulfilling inclusion criteria from the emergency department of District head Quarter hospital, Rawalpindi was taken. Informed consent was taken from patients or their attendants, and their demographic information like name, age, sex, and address was obtained. Alvarado score and Tzanakis score were calculated (as per operational definition) at the time of admission of the patients. After surgery, the specimen appendix was sent for histopathology in the hospital lab.  The diagnosis of the acute appendix was based on a positive histological report which was verified by a pathologist. All the data was entered by a researcher who will collect the data by himself. Results: The mean age of patients in this study was 20.15±7.13 years with 218 (51.9%) males and 202 (48.1%) females. The mean Alvardo score was recorded as 7.22±1.58 with the mean Tzanakis score being 9.64±3.13. The histopathology for diagnosing appendicitis showed positive for 367 (87.4%) patients and negative for 53 (12.6%) patients. The sensitivity of Alvarado score for diagnosing appendicitis, keeping histopathology as the gold standard was 86.92%, specificity was 92.45%, Positive Predictive Value was 98.76%, and Negative Predictive Value was 50.52% and overall diagnostic accuracy was 87.62%. The sensitivity of the Tzanakis score for diagnosing appendicitis, keeping histopathology as the gold standard was 88.83%, specificity was 88.6%, Positive Predictive Value was 98.19%, Negative Predictive Value was 53.41% and overall diagnostic accuracy was 88.81%. Conclusion: The sensitivity of the Tzanakis score was high when compared to the Alvarado score. And specificity was high in the Alvarado score when compared to the Tzanakis score. Moreover, the overall diagnostic accuracy of the Tzanakis score was high when compared to the Alvarado score. SoTzanakis score can be utilized to predict appendix and in the future, we can avoid negative appendectomies

Phosphorus Fertilizer Response to Onion (Allium cepa L.) Yield in Punjab, Pakistan

Background: Onion (Allium cepa L.) is one of the most essential plants in food with high nutritional value. However, application of right dose of phosphorous (P) is one of the constraints to the profitable onion yields in soils deficient in P.Methods: A systematic study to confirm the best dose of P was conducted for six years in the P deficient soil in farmers’ fields. Based on the findings obtained from 2008-09 to 2010-11, the research was undertaken to determine the effect of different phosphorus levels on the yield of onion in the Randomized Complete Block Design (RCBD) with a total of 114 replicates  in 2011-12 to 2012-13. Four treatments (160, 210, 260 and 310 kg P2O5 ha-1) were tested with N and K at 100 kg ha-1.Results: From the results of this investigation, the variance analysis showed the substantial P impact. The maximum marketable bulb yield (19.03 t ha-1) was obtained from the fertilizer combination NPK @ 100-310-100 kg ha-1 and was shown to be statistically higher than all other treatments.Conclusion: Nonetheless, the nutshell of the overall economic study is that poor farmers (Land holders >12 acres) may have options to select the NPK fertilizer combination @ 100:210:100 kg ha-1 and the average farmer may have options to select the NPK fertilizer combination @ 100:260:100 kg ha-1. But rich farmers (Land holders >25 acres) who can spend more money on fertilizers and are interested in the higher gross margin should follow the combination of NPK fertilizers @ 100:310:100 kg ha-1 to profitably increase their gross margin and maintain soil fertility for onion cultivation in Punjab, Pakistan.   Keywords: Onion; NPK; Plant nutrition; Phosphorus; Pungency

Awareness to Handle Research and Healthcare Waste (RHCW) in teaching and research institutes; a comprehensive review

Environmental pollution has become the major challenge not only for developing countries but also for developed ones Worldwide. The major goal of this comprehensive review is to compile the reference data regarding the different types of waste generated in teaching, research, and healthcare institutes and specific strategy to manage such wastes. In addition to the pharmaceutical, leather, chemicals, food, and paper industries, teaching, research, and healthcare institutions are also significant sources of different types of Non-hazardous as well as hazardous wastes. Therefore, a simple and implementable guideline for cleaning and waste disposal services in such institutions requires strict adherence to applicable policies and procedures. Research and healthcare waste (RHCW) management is a joint effort among Research Laboratory Personnel, Healthcare facilitators, Building Services Personnel, and Local Environmental Health and Safety Personnel. As Pakistan is among the developing countries situated in South Asia, most of the institutes, including teaching, research, and healthcare, try to follow the WHO guidance or manage hazardous and non-hazardous wastes with self-planned strategies. Although most of the local Governing bodies and Institutional bodies are trying to handle the wastes at their levels by following different protocols, introducing a protocol at the National level is the need of the current era to fight against environmental pollutants.

In vitro evaluation of antimicrobial and cytotoxic potential of Epimedium grandiflorum hydroethanolic extract as natural medicine

Medicinal plants are used as fundamental and low-cost source for remedy of numbers of infectious and metabolic diseases in developing and developed countries. Current research work was planned to evaluate the antibacterial, antifungal, and cytotoxic potential of hydroethanolic extract of E. grandiflorum. It was found that selected natural medicinal herb have significant (p<0.05) antibacterial activities tested against Bacillus subtilis, Staphylococcus aureus, Pasteurella multocida, Escherichia coli, Klebsiella pneumoniae, Acinetobacter species, Pseudomonas Species and Salmonella Species. The results of bacterial biofilm inhibition also explored that selected natural herb has significant (p<0.05) capacity to prevent the microbial biofilm particularly at higher dose. The results of antifungal activities showed that selected medicinal plant has significant (p<0.05) antifungal potential evaluated against Aspergillus flavus, Aspergillus niger, Aspergillus terreus, Fusarium solani, Alternata alternaria, and Schizophyllum species. Moreover, the results of mutagenicity test and DNA damage preventive test explored that selective medicinal plant has significant (p<0.05) DNA protective capacity or in other words it is non-mutagenic or cytotoxic in nature. It could be concluded that E. grandiflorum could be a potential candidate as therapeutic agent to manage infectious diseases especial bacterial and fungal infections with non-toxic nature