2 research outputs found
Bioactive phenylpropanoid analogues from <i>Piper betle</i> L. var. <i>birkoli</i> leaves
No full text<p>Phytochemical analyses of the chloroform extract of <i>Piper betle</i> L. var. <i>birkoli</i>, Piperaceae, leaves led to the isolation of two new phenylpropanoid analogues: <i>bis</i>-chavicol dodecanoyl ester (<b>2</b>) and <i>bis</i>-hydroxychavicol dodecanoyl ester (<b>3</b>), along with one known compound: <i>allyl</i>-3-methoxy-4-hydroxybenzene (<b>1</b>) on the basis of spectroscopic data 1D (<sup>1</sup>H and <sup>13</sup>C) and 2D (<sup>1</sup>H–<sup>1</sup>H COSY and HMBC) NMR, as well as ESI-MS, FT-IR, HR-ESI-MS and LC-ESI-MS. Compound <b>2</b> and <b>3</b> exhibited excellent antioxidant DPPH radical scavenging activity with IC<sub>50</sub> values of 12.67 μg/mL and 1.08 μg/mL compared to ascorbic acid as a standard antioxidant drug with IC<sub>50</sub> value of 6.60 μg/mL. Evaluation of cytotoxic activity against two human oral cancer cell lines (AW13516 and AW8507) showed significant effect with GI<sub>50</sub> values of 19.61 and 23.01 μg/mL for compound <b>2</b> and 10.25 and 13.12 μg/mL for compound <b>3</b>, compared to Doxorubicin<sup>®</sup> as a standard cytotoxic drug with GI<sub>50</sub> value of < 10 μg/mL.</p
New chemical constituents from the <i>Piper betle</i> Linn. (Piperaceae)
No full text<p>The phytochemical investigation of chloroform extract from <i>Piper betle</i> var. <i>haldia</i>, Piperaceae, leaves has resulted in the isolation of two new chemical constituents which were identified as 1-<i>n</i>-dodecanyloxy resorcinol (<b>H1</b>) and desmethylenesqualenyl deoxy-cepharadione-A (<b>H4</b>), on the basis of spectroscopic data 1D NMR (<sup>1</sup>H and <sup>13</sup>C) and 2D NMR (<sup>1</sup>H-<sup>1</sup>H COSY and HMBC) as well as ESI-MS, FT-IR and HR-ESI-MS analyses. Compounds <b>H1</b> and <b>H4</b> showed excellent antioxidant DPPH free radical scavenging activity with IC<sub>50</sub> values of 7.14 μg/mL and 8.08 μg/mL compared to ascorbic acid as a standard antioxidant drug with IC<sub>50</sub> value of 2.52 μg/mL, respectively. Evaluation of cytotoxic activity against human hepatoma cell line (PLC-PRF-5) showed moderate effect with the GI<sub>50</sub> values of 35.12 μg/mL for <b>H1</b>, 31.01 μg/mL for <b>H4</b>, compared to Doxorubicin<sup>®</sup> as a standard cytotoxic drug with GI<sub>50</sub> value of 18.80 μg/mL.</p
