Towards a portable platform integrated with multi-spectral non-contact probes for delineating normal and breast cancer tissue based on near-infrared spectroscopy

Currently, the confirmation of diagnosis of breast cancer is made by microscopic examination of an ultra-thin slice of a needle biopsy specimen. This slice is conventionally formalin-fixed and stained with hematoxylin-eosin and visually examined under a light microscope. This process is labor-intensive and requires highly skilled doctors (pathologists). In this paper, we report a novel tool based on near-infrared spectroscopy (Spectral-IRDx) which is a portable, non-contact, and cost-effective system and could provide a rapid and accurate diagnosis of cancer. The Spectral-IRDx tool performs absorption spectroscopy at near-infrared (NIR) wavelengths of 850 nm, 935 nm, and 1060 nm. We measure normalized detected voltage (Vdn) with the tool in 10 deparaffinized breast biopsy tissue samples, 5 of which were cancer (C) and 5 were normal (N) tissues. The difference in Vdn at 935 nm and 1060 nm between cancer and normal tissues is statistically significant with p-values of 0.0038 and 0.0022 respectively. Absorption contrast factor (N/C) of 1.303, 1.551, and 1.45 are observed for 850 nm, 935 nm, and 1060 nm respectively. The volume fraction contrast (N/C) of lipids and collagens are reported as 1.28 and 1.10 respectively. Higher absorption contrast factor (N/C) and volume fraction contrast (N/C) signifies higher concentration of lipids in normal tissues as compared to cancerous tissues, a basis for delineation. These preliminary results support the envisioned concept for non-invasive and non-carcinogenic NIR-based breast cancer diagnostic platform, which will be tested using a larger number of samples

Superconductivity-induced Phonon Renormalization on NaFe1−x_{1-x}Cox_{x}As

We report a study of the lattice dynamics in superconducting NaFeAs (Tc = 8 K) and doped NaFe0.97Co0.03As (Tc = 20 K) using Raman light scattering. Five of the six phonon modes expected from group theory are observed. In contrast with results obtained on iso-structural and iso-electronic LiFeAs, anomalous broadening of Eg(As) and A1g(Na) modes upon cooling is observed in both samples. In addition, in the Co-doped sample, a superconductivity-induced renormalization of the frequency and linewidth of the B1g(Fe) vibration is observed. This renormalization can not be understood within a single band and simple multi-band approaches. A theoretical model that includes the effects of SDW correlations along with sign-changing s-wave pairing state and interband scattering has been developed to explain the observed behavior of the B1g(Fe) mode.Comment: 10 pages; 6 figure

Phonon arithmetic in a trapped ion system

Single-quantum level operations are important tools to manipulate a quantum state. Annihilation or creation of single particles translates a quantum state to another by adding or subtracting a particle, depending on how many are already in the given state. The operations are probabilistic and the success rate has yet been low in their experimental realization. Here we experimentally demonstrate (near) deterministic addition and subtraction of a bosonic particle, in particular a phonon of ionic motion in a harmonic potential. We realize the operations by coupling phonons to an auxiliary two-level system and applying transitionless adiabatic passage. We show handy repetition of the operations on various initial states and demonstrate by the reconstruction of the density matrices that the operations preserve coherences. We observe the transformation of a classical state to a highly non-classical one and a Gaussian state to a non-Gaussian one by applying a sequence of operations deterministically

Quantum state conversion by cross-Kerr interaction

A generalized Mach-Zehnder-type interferometer equipped with cross-Kerr elements is proposed to convert N-photon truncated single-mode quantum states into (N+1)-mode single-photon states, which are suitable for further state manipulation by means of beam splitter arrays and ON/OFF-detections, and vice versa. Applications to the realization of unitary and non-unitary transformations, quantum state reconstruction, and quantum telemanipulation are studied.Comment: 22 pages, 4 figures, using a4.st

Raman Scattering Study of the Lattice Dynamics of Superconducting LiFeAs

We report an investigation of the lattice dynamical properties of LiFeAs using inelastic light scattering. Five out of the six expected phonon modes are observed. The temperature evolution of their frequencies and linewidths is in good agreement with an anharmonic-decay model. We find no evidence for substantial electron-phonon coupling, and no superconductivity-induced phonon anomalies.Comment: 5 pages, 3 figures, 1 tabl

Effect of betaine and ascorbic acid in drinking water on growth performance and blood biomarkers in meat ducks exposed to heat stress

The aim of this study was to compare the effect of drinking water that contains various levels of ascorbic acid (AA) and betaine (BT) on growth performance and blood biomarkers in meat ducks exposed to heat stress. Six hundred and forty one-day-old Cherry Valley ducks were randomly assigned to one of seven treatment groups: i) control group, drinking water without ascorbic acid or betaine, ii) AA100, drinking water containing ascorbic acid at 100 milligrams per litre, iii) AA200, drinking water containing ascorbic acid at 200 milligrams per litre, iv) AA300, drinking water containing ascorbic acid at 300 milligrams per litre, v) BT400, drinking water containing betaine at 400 milligrams per litre, vi) BT800, drinking water containing betaine at 800 milligrams per litre, and vii) BT1200, drinking water containing betaine at 1200 milligrams per litre. The ducks were exposed to heat stress (11:00 to 17:00, 33 °C to 43 °C, relative humidity 70%, artificially controlled-environment houses) from the 22nd to 42nd days. Ducks from treatment groups AA300 and BT1200 displayed significantly increased bodyweight gains compared with those in the control group. Blood levels of glucose, and activities of aspartate aminotransferase and alanine aminotransferase in all treatment groups were significantly lower than those observed in the control group. Red blood cell count, platelet number, electrolytes and blood gas concentrations were significantly higher in all treatment groups compared with those in the control group. Blood pH levels in all treatment groups were lower than those in the control group. In conclusion, drinking water containing ascorbic acid or betaine improved the growth performance via biomarker homeostasis in blood of meat ducks exposed to heat stress.Keywords: body weight gain, blood lipid, red blood cell, electrolytes; blood gas, blood p

Proteolytic degradation and potential role of onconeural protein cdr2 in neurodegeneration

Cerebellar degeneration-related protein 2 (cdr2) is expressed in the central nervous system, and its ectopic expression in tumor cells of patients with gynecological malignancies elicits immune responses by cdr2-specific autoantibodies and T lymphocytes, leading to neurological symptoms. However, little is known about the regulation and function of cdr2 in neurodegenerative diseases. Because we found that cdr2 is highly expressed in the midbrain, we investigated the role of cdr2 in experimental models of Parkinson's disease (PD). We found that cdr2 levels were significantly reduced after stereotaxic injection of 1-methyl-4-phenylpyridinium (MPP+) into the striatum. cdr2 levels were also decreased in the brains of post-mortem PD patients. Using primary cultures of mesencephalic neurons and MN9D cells, we confirmed that MPP + reduces cdr2 in tyrosine hydroxylase-positive dopaminergic neuronal cells. The MPP+-induced decrease of cdr2 was primarily caused by calpain-and ubiquitin proteasome system-mediated degradation, and cotreatment with pharmacological inhibitors of these enzymes or overexpression of calcium-binding protein rendered cells less vulnerable to MPP+-mediated cytotoxicity. Consequently, overexpression of cdr2 rescued cells from MPP+-induced cytotoxicity, whereas knockdown of cdr2 accelerated toxicity. Collectively, our findings provide insights into the novel regulatory mechanism and potentially protective role of onconeural protein during dopaminergic neurodegeneration. © 2016 Macmillan Publishers Limited All rights reserved.1

Constraints on the geometry of the subducted Gorda Plate from converted phases generated by local earthquakes

Author Posting. © American Geophysical Union, 2021. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 126(2), (2021): e2020JB019962, https://doi.org/10.1029/2020JB019962.The largest slip in great megathrust earthquakes often occurs in the 10–30 km depth range, yet seismic imaging of the material properties in this region has proven difficult. We utilize a dense onshore‐offshore passive seismic dataset from the southernmost Cascadia subduction zone where seismicity in the mantle of the subducted Gorda Plate produces S‐to‐P and P‐to‐S conversions generated within a few km of the plate interface. These conversions typically occur in the 10–20 km depth range at either the top or bottom of a ∼5 km thick layer with a high Vp/Vs that we infer to be primarily the subducted crust. We use their arrival times and amplitudes to infer the location of the top and bottom of the subducted crust as well as the velocity contrasts across these discontinuities. Comparing with both the Slab1.0 and the updated Slab2 interface models, the Slab2 model is generally consistent with the converted phases, while the Slab1.0 model is 1–2 km deeper in the 2–20 km depth range and ∼6–8 km too deep in the 10–20 km depth range between 40.25°N and 40.4°N. Comparing the amplitudes of the converted phases to synthetics for simplified velocity structures, the amplitude of the converted phases requires models containing a ∼5 km thick zone with at least a ∼10%–20% reduction in S wave velocity. Thus, the plate boundary is likely contained within or at the top of this low velocity zone, which potentially indicates a significant porosity and fluid content within the seismogenic zone.This work is funded by National Science Foundation Award Numbers EAR‐1520690.2021-07-2

Secrecy Results for Compound Wiretap Channels

We derive a lower bound on the secrecy capacity of the compound wiretap channel with channel state information at the transmitter which matches the general upper bound on the secrecy capacity of general compound wiretap channels given by Liang et al. and thus establishing a full coding theorem in this case. We achieve this with a stronger secrecy criterion and the maximum error probability criterion, and with a decoder that is robust against the effect of randomisation in the encoding. This relieves us from the need of decoding the randomisation parameter which is in general not possible within this model. Moreover we prove a lower bound on the secrecy capacity of the compound wiretap channel without channel state information and derive a multi-letter expression for the capacity in this communication scenario.Comment: 25 pages, 1 figure. Accepted for publication in the journal "Problems of Information Transmission". Some of the results were presented at the ITW 2011 Paraty [arXiv:1103.0135] and published in the conference paper available at the IEEE Xplor