Malignant transformation of endometriosis on vaginal cuff after hysterectomy: a case report

Objective. Endometriotic tissue implants rarely transform to malignant tissue, especially in a patient with a hysterectomy and bilaterally salpingo-oophorectomy. However, several cases with cancer arising from endometriosis after hysterectomy were reported in the literature. Hormone replacement therapy only with estrogen is a crucial risk factor for malignant transformation of persistent endometriotic tissue. Case Report. The present case demonstrates an endometrioid adenocarcinoma arising from persistent endometriosis tissue in a patient who was performed hysterectomy with bilateral salpingectomy 3 years ago. The histopathologic specimens of the previous surgery did not include any malignant tissue. After 3 years, she applied to the hospital with abnormal vaginal bleeding, and her histopathologic examination result found an ulcerated mass at the upper one-third of the vagina that is compatible with endometrioid adenocarcinoma. Conclusion. It is crucial to keep in mind the endometriosis history of the patient, to be able to diagnose cancer arising from endometriosis while evaluating the patient with a hysterectomy

Multiple pulmonary hyalinizing granulomas mimicking widespread lung metastasis

Pulmonary hyalinizing granuloma (PHG) is a rare benign lesion that can be unilaterally or bilaterally presented in the form of solitary or multiple nodules and masses. It may also be related to mediastinal and retroperitoneal fibrosis, autoimmune diseases, tumors, or infectious diseases. The definitive diagnosis of PHG can only be made by pathological evaluation. A 64-year-old male applied to the hospital to undergo an inguinal hernia repair operation. Preoperative chest imaging revealed multiple pulmonary nodules with lobulated contours and regular margins scattered throughout both lungs. Pathologic evaluation revealed that nodules were consistent with PHG. In addition, soft-tissue density observed around the abdominal aorta was compatible with retroperitoneal fibrosis, which may accompany this disease

Expression of interleukin-8 and monocyte chemotactic protein 1 in women with endometriosis

Objective: To investigate the expression and localization of interleukin-8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) in women with and without endometriosis