734 research outputs found

    Neuroimmune perspectives in sepsis

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    Physiologic anti-inflammatory mechanisms are selected by evolution to control the immune system and to prevent infectious and inflammatory disorders. Central-acting α2-agonists attenuate systemic inflammation and improve survival in experimental sepsis. This anti-inflammatory and therapeutic mechanism of central sympatholytics appears to be mediated by an unexpected vagomimetic potential of the α2-agonists to activate the vagus nerve. Recent studies, however, rule out a cholinergic anti-inflammatory mechanism based on a direct cholinergic interaction between the vagus nerve and the immune system. Since the nervous system is the principal regulator of the immune system, physiologic studies understanding the neuroimmune connections can provide major advantages to design novel therapeutic strategies for sepsis

    La cobertura informativa de la violencia de género en medios impresos de Guadalajara, Jalisco, México. El caso de Imelda Virgen

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    El feminicidio es un tema que en el periodismo requiere de investigación exhaustiva y precisión de datos para informar a la sociedad de manera objetiva, sin amarillismo, sensacionalismo o culpabilización de las mujeres. Así como de capacitación y actualización de los periodistas por parte de autoridades, colectivos u académicos para no obviar los asuntos de género en cobertura y tratamiento informativo. El caso de Imelda Virgen y el incremento de violencia de género en el estado de Jalisco, México, son hechos noticiables, pero también motivo para el análisis y prospectiva de prácticas periodísticas en el tratamiento informativo de un fenómeno complejo y universal

    Another look at State responsibility in money laundering and the massive and habitual collection of money from the public

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    A critical reflection is exposed with regards to the responsibility of the Colombian State in the surveillance, control and action that it must carry out, from the administrative field, in relation to the practices of money laundering and massive and habitual collection of money from the perspective of the omission and legitimate expectation

    Prensa en Facebook : la importancia de la imagen en la web social

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    Facebook, con una penetración del 79% en España, se ha convertido en una importante plataforma de difusión de noticias. El presente estudio tiene por objetivo describir el comportamiento de los usuarios ante la presencia de noticias en el muro. Para ello se ha realizado un estudio experimental en la Universitat Pompeu Fabra con 24 usuarios de Facebook. Siguiendo una distribución de tipo latin square, se mostró a cada participante tres muros de Facebook; cada muro contenía una noticia en tres formatos. Se les pidió que escogieran entre ellas según su preferencia. El proceso se grabó con un dispositivo de eye tracking, que además de seguir la visión foveal guarda registro de los clics y del tiempo de permanencia en una página. Al finalizar la grabación se preguntó a los usuarios qué formato de noticia preferían. El estudio pone de relieve las diferencias de percepción, selección y preferencia de los usuarios de Facebook ante diversos formatos, donde la imagen se erige en elemento principal.Laboratorio de Estudios en Comunicación (LADECOM)Grupo de Investigación en Estructura, Historia y Contenidos de la Comunicación (GREHCCO) HUM61

    Polarization and Aharonov-Bohm oscillations in quantum-ring magnetoexcitons

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    We study interaction and radial polarization effects on the the absorption spectrum of neutral bound magnetoexcitons confined in quantum-ring structures. We show that the size and orientation of the exciton's dipole moment, as well as the interaction screening, play important roles in the Aharonov-Bohm oscillations. In particular, the excitonic absorption peaks display A-B oscillations both in position and amplitude for weak electron-hole interaction and large radial polarization. The presence of impurity scattering induces anticrossings in the exciton spectrum, leading to a modulation in the absorption strength. These properties could be used in experimental investigations of the effect in semiconductor quantum-ring structures.Comment: Updated version, 6 pages, 4 figures. To appear in Phys. Rev.

    Representación de las comunidades indígenas de México en medios impresos universitarios. Caso: La gaceta de la Universidad de Guadalajara

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    Los medios universitarios, producidos por las Instituciones de Educación Superior, son instrumentos de apoyo para revalorizar el papel de grupos discriminados. Es el caso de las comunidades indígenas de México, que tienen en los diarios una presencia reducida a notas de violencia o censos indígenas. Desde la rutina del ejercicio periodístico se evalúa el trabajo del periódico institucional de la Universidad de Guadalajara para reflejar en las páginas de La gaceta de la Universidad de Guadalajara, la misión de la Institución: respeto de la diversidad cultural. Asimismo, describir las formas de presentación en el periódico al difundir su cultura e historia.The mass media university produced by the Universities, are instruments of support to revalue the paper of the discriminated groups, in this case the communities indigenous to Mexico. In newpapers means information relative to they, his presence is reducing in articles related to violence or indigenous census. From the journalistic exercise there is evaluated the work of the institutional newspaper of the University of Guadalajara, to reflect in the pages The gazette of the University of Guadalajara the mission of the Institution: respect of the cultural diversity. Likewise, to describe the forms of contribution of the newspaper in the diffusion of the culture and history

    Functional typological approach to Shawi indeterminate pronouns

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    This study describes the formation of indeterminate pronouns in Shawi, which is a class of proforms that can have interrogative, indefinite, and free relative senses. These interpretations are only distinguished through a class of clitics, e.g. ma’=ta (what, relative what), ma’=sha (something), ma=nta (nothing). The first of these can be further modified to ma’ta=ka (rhetorical what) and ma’=tana (whatever). As in other languages, this class of proforms can be categorized into a paradigm in which each member represents a general concept like person (who), thing (what), place (where), time (when), manner (how), etc. Comparing these forms reveals further internal structure. As such, Shawi indeterminate pronouns are analyzed and the clitics that can modify their interpretation are discussed

    Tunable pseudogap Kondo effect and quantum phase transitions in Aharonov-Bohm interferometers

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    We study two quantum dots embedded in the arms of an Aharonov-Bohm ring threaded by a magnetic flux. The system can be described by an effective one-impurity Anderson model with an energy- and flux-dependent density of states. For specific values of the flux, this density of states vanishes at the Fermi energy, yielding a controlled realization of the pseudogap Kondo effect. The conductance and transmission phase shifts reflect a nontrivial interplay between wave interference and interactions, providing clear signatures of quantum phase transitions between Kondo and non-Kondo ground states.Comment: Published versio

    Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage

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    The inflammatory responses in sepsis and hemorrhage remain a major cause of death. Clinically, it is generally accepted that shock in sepsis or hemorrhage differs in its mechanisms. However, the recognition of inflammatory cytokines as a common lethal pathway has become consent. Proinflammatory cytokines such as tumor necrosis factor (TNF) or high-mobility group box1 (HMGB1) are fanatically released and cause lethal multiorgan dysfunction. Inhibition of these cytokines can prevent the inflammatory responses and organ damage. In seeking potential anti-inflammatory strategies, we reported that ethyl pyruvate and alpha7 nicotinic acetylcholine receptor (alpha7nAChR) agonists effectively restrained cytokine production to provide therapeutic benefits in both experimental sepsis and hemorrhage. Here, we review the inflammatory responses and the anti-inflammatory strategies in experimental models of sepsis and hemorrhage, as they may have a consistent inflammatory pathway in spite of their different pathophysiological processes
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