Physical and mechanical characterization of sand replaced stone dust concrete

In this research work, physical, chemical, morphological, and mechanical behavior as partial replacement of fine aggregate in concrete. Stone dust was acquired from three different sources i.e. Nowshera, Dara, and Besai, while concrete was kept at a ratio of 1:2:4 and water to cement ratio at 0.5 as per ASTM standards for considerable workability. The compressive strength, ultrasonic pulse velocity (UPV), its correlation, density, durability test, x-ray fluorescence (XRF) analysis, and Scanning electron microscopy was carried out. Compressive strength at curing ages of 7, 14, and 28 days with 20%, 30%, and 40% replacement of sand was incorporated in concrete. The results indicated a slight increase in compressive strength at 20% replacement level for the Besai Concrete (BC), Nowshera Concrete (NC), and Dara Concrete (DC). For durability analysis; Rapid Chloride Permeability Test (RCPT) carried out on hardened stone dust-based concrete shows that with the addition of stone dust the voids between fine and coarse aggregates are filled up, less charge will pass, and ultimately durability is increased as per ASTM C 1202. The chemical composition of the stone dust samples, through XRF analysis, indicated that Silica dioxide (SiO2) compounds present in (NC), (DC), and (BC) were 13.34%, 12.339% & 11.593% respectively. The maximum compressive strength development in NC was possibly due to the presence of SiO _2 compound in excess quantity in Nowshera stone dust as compared to other samples tested. Hence it can be recommended that locally available stone dust in Peshawar and its surrounding are suitable for a maximum of 40% replacement level

Knee Osteoarthritis: Steriods Verus Platelets Rich Plasma Effectiveness

<p>Background: This study compared the effectiveness of two therapy techniques for treating a certain medical condition: intra-articular steroid injection (Group A) and platelet rich plasma injection (Group B). The medial femorotibial compartment, for instance, frequently exhibits the highest decrease of joint space in the osteoarthritic knee. Treatment for osteoarthritis aims to reduce discomfort and enhance functional status.  Medium-term improvements are seen with intra- articular platelet-rich plasma, balneotherapy, and  whole-body vibration. The study is intended to demonstrate knee osteoarthritis and establish appropriate treatment guidelines. to determine the mean VAS score in individuals with knee osteoarthritis after intra-articular PRP or steroid injection and to evaluate which treatment is more effective at reducing pain for patients with osteoarthritis of the knee: PRP or steroid injections. Methodology: Department of Orthopedics Surgery & Trauma, lady reading hospital peshawer, UPON ETHICAL Comitte Approval. Thirty patients with knee osteoarthritis were studied in each group from 1 JAN 2022 to 31 December 2022. PRP and steroid groups of patients were randomly assigned using randomization through non-probability consecutive sampling. SPSS-24 Version was used to recode and analyze the results of the CONTROL TRIAL. The male-to-female ratio, age distribution, and pain outcomes both before and after  treatment were also examined in the study. The male-to- female ratio in Group A was 1:3, whereas the ratio in  Group B was 1:3.75. Both therapies were used, and their  effects in reducing pain were evaluated. The results showed that both groups had a larger proportion of females. The groups' age distributions varied, but there were no statistically significant differences between them. Results: The study consisted of 60 patients in total. They were evenly divided between the two groups. Patients in group A had a mean age of 59.93 years plus 7.48 standard deviations, whereas those in group B had a mean age of 61.68 years plus 7.22 SD. After treatment, when pain levels were compared, Group A reported 4.7+1.31SD of pain, whereas Group B reported 6.03+1.18SD of pain. This difference was statistically significant using an independent t-test, with a p-value of 0.000. Pre-treatment pain levels between Group A (mean: 7.93) and Group B (mean: 8.03) were comparable, and there was little change after therapy. In contrast, Group A showed a statistically significant reduction in pain following therapy (mean: 4.7) as compared to Group B (mean: 6.03). Conclusion: This study highlights the potential advantages of intra-articular steroid injections versus platelet rich plasma injections for the treatment of pain.</p><p>Keywords:- Knee Osteoarthritis, Steroid, Platelet Rich Plasma.</p&gt

Global variations in heart failure etiology, management, and outcomes

Importance: Most epidemiological studies of heart failure (HF) have been conducted in high-income countries with limited comparable data from middle- or low-income countries. Objective: To examine differences in HF etiology, treatment, and outcomes between groups of countries at different levels of economic development. Design, Setting, and Participants: Multinational HF registry of 23 341 participants in 40 high-income, upper–middle-income, lower–middle-income, and low-income countries, followed up for a median period of 2.0 years. Main Outcomes and Measures: HF cause, HF medication use, hospitalization, and death. Results: Mean (SD) age of participants was 63.1 (14.9) years, and 9119 (39.1%) were female. The most common cause of HF was ischemic heart disease (38.1%) followed by hypertension (20.2%). The proportion of participants with HF with reduced ejection fraction taking the combination of a β-blocker, renin-angiotensin system inhibitor, and mineralocorticoid receptor antagonist was highest in upper–middle-income (61.9%) and high-income countries (51.1%), and it was lowest in low-income (45.7%) and lower–middle-income countries (39.5%) (P < .001). The age- and sex- standardized mortality rate per 100 person-years was lowest in high-income countries (7.8 [95% CI, 7.5-8.2]), 9.3 (95% CI, 8.8-9.9) in upper–middle-income countries, 15.7 (95% CI, 15.0-16.4) in lower–middle-income countries, and it was highest in low-income countries (19.1 [95% CI, 17.6-20.7]). Hospitalization rates were more frequent than death rates in high-income countries (ratio = 3.8) and in upper–middle-income countries (ratio = 2.4), similar in lower–middle-income countries (ratio = 1.1), and less frequent in low-income countries (ratio = 0.6). The 30-day case-fatality rate after first hospital admission was lowest in high-income countries (6.7%), followed by upper–middle-income countries (9.7%), then lower–middle-income countries (21.1%), and highest in low-income countries (31.6%). The proportional risk of death within 30 days of a first hospital admission was 3- to 5-fold higher in lower–middle-income countries and low-income countries compared with high-income countries after adjusting for patient characteristics and use of long-term HF therapies. Conclusions and Relevance: This study of HF patients from 40 different countries and derived from 4 different economic levels demonstrated differences in HF etiologies, management, and outcomes. These data may be useful in planning approaches to improve HF prevention and treatment globally