251 research outputs found
Boolean network-based model of the Bcl-2 family mediated MOMP regulation
Mitochondrial outer membrane permeabilization (MOMP) is one of the most
important points, in majority of apoptotic signaling cascades. Decision
mechanism controlling whether the MOMP occurs or not, is formed by an interplay
between members of the Bcl-2 family. To understand the role of individual
members of this family within the MOMP regulation, we constructed a boolean
network-based mathematical model of interactions between the Bcl-2 proteins.
Results of computational simulations reveal the existence of the potentially
malign configurations of activities of the Bcl-2 proteins, blocking the
occurrence of MOMP, independently of the incoming stimuli. Our results suggest
role of the antiapoptotic protein Mcl-1 in relation to these configurations. We
demonstrate here, the importance of the Bid and Bim according to activation of
effectors Bax and Bak, and the irreversibility of this activation. The model
further shows the distinct requirements for effectors activation, where the
antiapoptic protein Bcl-w is seemingly a key factor preventing the Bax
activation. We believe that this work may help to describe the functioning of
the Bcl-2 regulation of MOMP better, and hopefully provide some contribution
regarding the anti-cancer drug development research
Crowd simulation for dynamic environments based on information spreading and agents’ personal interests
In this work a novel crowd simulation framework that incorporates information of the dynamic environment is introduced. It supports knowledge spreading and allows the simulated agents to behave according to their personal needs that are affected by the surroundings. Each agent has their own personal interests and needs, which affects its goals and interactions with the environment. Genetic algorithms are used to simulate the dynamic behaviour of the environment and the knowledge spreading. As a result more accurate and realistic simulations are obtained improving a wide range of industrial and research applications that require accurate crowd simulation and modelling
Issues in the philosophical foundations of lexical semantics
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 1993.Includes bibliographical references (leaves 152-159).by Brian Edward Ulicny.Ph.D
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