Pharmacotherapy of obsessive-compulsive disorder during pregnancy: a clinical approach

Obsessive-compulsive disorder (OCD) is a relatively common psychiatric disorder in the perinatal period. However, specific pharmacological treatment approaches for patients with OCD during pregnancy have not been satisfactorily discussed in the literature. In addition, there are no randomized controlled studies on the treatment of this disorder during pregnancy. The present paper discusses the pharmacological treatment of OCD in the light of data on the safety of antipsychotics and serotonergic antidepressants during pregnancy and their efficacy in the non-perinatal period. Treatment decisions should be individualized because the risk-benefit profile of pharmacotherapy is an important issue in the treatment of pregnant women with any psychiatric diagnosis

Perinatal Psychopharmacology

This book focuses on recent advances in research and practical recommendations regarding the use of psychotropic drugs during pregnancy and lactation, two important social and psychological life events for women. In addition to the social context, including the addition of a new family member, many women experience the occurrence or recurrence of psychiatric disorders during the perinatal period. Psychiatric disorders during this period can have negative effects on the fetus, infant and other children in the family, and can result in functional impairment among mothers. The book offers a comprehensive overview of psychopharmacological treatments for nearly all specific psychiatric conditions (e.g. bipolar disorder, panic disorder, obsessive-compulsive disorder) and includes chapters on clinical approaches to treating these disorders. As such, it will appeal to a wide readership, including psychiatrists, obstetricians, gynecologists and pediatricians

Investigation of premenstrular dysphoric disorder comorbidity and related factors in patients with anxiety disorder

Abstract Aim: Because of the fact that the frequency of both anxiety disorders and premenstrual dysphoric disorder (PMDD) are high in women and that studies investigating PMDD comorbidity in patients diagnosed with anxiety disorder are limited, this study was aimed to investigate PMDD comorbidity and related factors in patients with anxiety disorders. Materials and Methods: 183 subjects who were followed up with a diagnosis of anxiety disorder in Necmettin Erbakan University Meram Medical Faculty Psychiatry Outpatient Clinic were included in the study and were evaluated with Sociodemographic Data Form, Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI). PMDD comorbidity was investigated according to The Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV-TR) criteria by making psychiatric interviews. Results: 57 (31.2%) of 183 subjects diagnosed with PMDD constituted the PMDD group and the remaining 126 patients constituted the non-PMDD group. The mean BAI scores of the PMDD group were significantly higher than those of the non PMDD group, whereas the mean age of the PMDD group was significantly lower than that of the non PMDD group. The BMI of the PMDD group was significantly higher than that of the non PMDD group. Conclusion: PMDD is common in patients followed up with a diagnosis of anxiety disorder and what is associated with PMDD is be young age as well as excessive chocolate consumption.</div

Sertraline-induced periorbital purpura: a case report

WOS: 000358591400024PubMed ID: 25964653Objective: The incidence of mild to severe levels of spontaneous bleeding due to the usage of selective serotonin reuptake inhibitors (SSRIs) is relatively low. Although the exact mechanism is not known, it is thought that inhibition of the serotonin transporter together with a decrease in platelet serotonin could be responsible for the bleeding. Therefore, the use of SSRIs in conjunction with anti-aggregants may predispose to or exacerbate the risk of bleeding. In this case report, we describe a 44-year-old female patient with a diagnosis of anxiety disorder who spontaneously developed periorbital purpura during treatment with sertraline. Conclusion: Abnormal bleeding after treatment with an SSRI should be kept in mind, and alternative non-SSRI drugs of choice in such cases would be more appropriate. More extensive and comprehensive studies focusing on hemostasis and bleeding disorders are needed for SSRIs such as sertraline

Postpartum-onset obsessive-compulsive disorder: Incidence, clinical features, and related factors

Conclusions: This study suggests that the puerperium is a risk period in terms of new-onset OCD and that avoidant and obsessive-compulsive personality disorders predict PPOCD

Quality of life in patients with Behcet's disease: the impact of major depression

Conclusion: The study suggests that concurrent MD has a negative impact on QoL of BD patients and that QoL is negatively correlated with the severity of depressive symptoms. (c) 2007 Elsevier Inc. All rights reserved