264 research outputs found
Self-similar solution of fast magnetic reconnection: Semi-analytic study of inflow region
An evolutionary process of the fast magnetic reconnection in ``free space''
which is free from any influence of outer circumstance has been studied
semi-analytically, and a self-similarly expanding solution has been obtained.
The semi-analytic solution is consistent with the results of our numerical
simulations performed in our previous paper (see Nitta et al. 2001). This
semi-analytic study confirms the existence of self-similar growth. On the other
hand, the numerical study by time dependent computer simulation clarifies the
stability of the self-similar growth with respect to any MHD mode. These
results confirm the stable self-similar evolution of the fast magnetic
reconnection system.Comment: 15 pages, 7 figure
Species D human adenovirus type 9 exhibits better virus-spread ability for antitumor efficacy among alternative serotypes
Species C human adenovirus serotype 5 (HAdV-C5) is widely used as a vector for cancer gene therapy, because it efficiently transduces target cells. A variety of HAdV-C5 vectors have been developed and tested in vitro and in vivo for cancer gene therapy. While clinical trials with HAdV-C5 vectors resulted in effective responses in many cancer patients, administration of HAdV-C5 vectors to solid tumors showed responses in a limited area. A biological barrier in tumor mass is considered to hinder viral spread of HAdV-C5 vectors from infected cells. Therefore, efficient virus-spread from an infected tumor cell to surrounding tumor cells is required for successful cancer gene therapy. In this study, we compared HAdV-C5 to sixteen other HAdV serotypes selected from species A to G for virus-spread ability in vitro. HAdV-D9 showed better virus-spread ability than other serotypes, and its viral progeny were efficiently released from infected cells during viral replication. Although the HAdV-D9 fiber protein contains a binding site for coxsackie B virus and adenovirus receptor (CAR), HAdV-D9 showed expanded tropism for infection due to human CAR (hCAR)-independent attachment to target cells. HAdV-D9 infection effectively killed hCAR-negative cancer cells as well as hCAR-positive cancer cells. These results suggest that HADV-D9, with its better virus-spread ability, could have improved therapeutic efficacy in solid tumors compared to HAdV-C5
Patchy Reconnection in a Y-Type Current Sheet
We study the evolution of the magnetic field in a Y-type current sheet
subject to a brief, localized magnetic reconnection event. The reconnection
produces up- and down-flowing reconnected flux tubes which rapidly decelerate
when they hit the Y-lines and underlying magnetic arcade loops at the ends of
the current sheet. This localized reconnection outflow followed by a rapid
deceleration reproduces the observed behavior of post-CME downflowing coronal
voids. These simulations support the hypothesis that these observed coronal
downflows are the retraction of magnetic fields reconnected in localized
patches in the high corona.Comment: 4 pages, 3 figure
Fast magnetic reconnection in free space: self-similar evolution process
We present a new model for time evolution of fast magnetic reconnection in
free space, which is characterized by self-similarity. Reconnection triggered
by locally enhanced resistivity assumed at the center of the current sheet can
self-similarly and unlimitedly evolve until external factors affect the
evolution. The possibility and stability of this type of evolution are verified
by numerical simulations in a very wide spatial dynamic range. Actual
astrophysical reconnection in solar flares and geomagnetospheric substorms can
be treated as an evolutionary process in free space, because the resultant
scale is much larger than the initial scale. In spite of this fact, most of the
previous numerical works focused on the evolutionary characters strongly
affected by artificial boundary conditions on the simulation boundary. Our new
model clarifies a realistic evolution for such cases. The characteristic
structure around the diffusion region is quite similar to the Petschek model
which is characterized by a pair of slow-mode shocks and the fast-mode
rarefaction-dominated inflow. However, in the outer region, a vortex-like
return flow driven by the fast-mode compression caused by the piston effect of
the plasmoid takes place. The entire reconnection system expands
self-similarly.Comment: 17 Pages, 17 Figure
A multi targeting conditionally replicating adenovirus displays enhanced oncolysis while maintaining expression of immunotherapeutic agents
Studies have demonstrated that oncolytic adenoviruses based on a 24 base pair deletion in the viral E1A gene (D24) may be promising therapeutics for treating a number of cancer types. In order to increase the therapeutic potential of these oncolytic viruses, a novel conditionally replicating adenovirus targeting multiple receptors upregulated on tumors was generated by incorporating an Ad5/3 fiber with a carboxyl terminus RGD ligand. The virus displayed full cytopathic effect in all tumor lines assayed at low titers with improved cytotoxicity over Ad5-RGD D24, Ad5/3 D24 and an HSV oncolytic virus. The virus was then engineered to deliver immunotherapeutic agents such as GM-CSF while maintaining enhanced heterogenic oncolysis
Magnetic Reconnection Triggered by the Parker Instability in the Galaxy: Two-Dimensional Numerical Magnetohydrodynamic Simulations and Application to the Origin of X-Ray Gas in the Galactic Halo
We propose the Galactic flare model for the origin of the X-ray gas in the
Galactic halo. For this purpose, we examine the magnetic reconnection triggered
by Parker instability (magnetic buoyancy instability), by performing the
two-dimensional resistive numerical magnetohydrodynamic simulations. As a
result of numerical simulations, the system evolves as following phases: Parker
instability occurs in the Galactic disk. In the nonlinear phase of Parker
instability, the magnetic loop inflates from the Galactic disk into the
Galactic halo, and collides with the anti-parallel magnetic field, so that the
current sheets are created in the Galactic halo. The tearing instability
occurs, and creates the plasmoids (magnetic islands). Just after the plasmoid
ejection, further current-sheet thinning occurs in the sheet, and the anomalous
resistivity sets in. Petschek reconnection starts, and heats the gas quickly in
the Galactic halo. It also creates the slow and fast shock regions in the
Galactic halo. The magnetic field (G), for example, can heat the
gas ( cm) to temperature of K via the
reconnection in the Galactic halo. The gas is accelerated to Alfv\'en velocity
( km s). Such high velocity jets are the evidence of the
Galactic flare model we present in this paper, if the Doppler shift of the
bipolar jet is detected in the Galactic halo. Full size figures are available
at http://www.kwasan.kyoto-u.ac.jp/~tanuma/study/ApJ2002/ApJ2002.htmlComment: 13 pages, 12 figures, uses emulateapj.sty, accepted by Ap
Self-Consistent MHD Modeling of a Coronal Mass Ejection, Coronal Dimming, and a Giant Cusp-Shaped Arcade Formation
We performed magnetohydrodynamic simulation of coronal mass ejections (CMEs)
and associated giant arcade formations, and the results suggested new
interpretations of observations of CMEs. We performed two cases of the
simulation: with and without heat conduction. Comparing between the results of
the two cases, we found that reconnection rate in the conductive case is a
little higher than that in the adiabatic case and the temperature of the loop
top is consistent with the theoretical value predicted by the Yokoyama-Shibata
scaling law. The dynamical properties such as velocity and magnetic fields are
similar in the two cases, whereas thermal properties such as temperature and
density are very different.In both cases, slow shocks associated with magnetic
reconnectionpropagate from the reconnection region along the magnetic field
lines around the flux rope, and the shock fronts form spiral patterns. Just
outside the slow shocks, the plasma density decreased a great deal. The soft
X-ray images synthesized from the numerical results are compared with the soft
X-ray images of a giant arcade observed with the Soft X-ray Telescope aboard
{\it Yohkoh}, it is confirmed that the effect of heat conduction is significant
for the detailed comparison between simulation and observation. The comparison
between synthesized and observed soft X-ray images provides new interpretations
of various features associated with CMEs and giant arcades.Comment: 39 pages, 18 figures. Accepted for publication in the Astrophysical
Journal. The PDF file with high resplution figures can be downloaded from
http://www.kwasan.kyoto-u.ac.jp/~shiota/study/ApJ62426.preprint.pdf
Plasmoid-Induced-Reconnection and Fractal Reconnection
As a key to undertanding the basic mechanism for fast reconnection in solar
flares, plasmoid-induced-reconnection and fractal reconnection are proposed and
examined. We first briefly summarize recent solar observations that give us
hints on the role of plasmoid (flux rope) ejections in flare energy release. We
then discuss the plasmoid-induced-reconnection model, which is an extention of
the classical two-ribbon-flare model which we refer to as the CSHKP model. An
essential ingredient of the new model is the formation and ejection of a
plasmoid which play an essential role in the storage of magnetic energy (by
inhibiting reconnection) and the induction of a strong inflow into reconnection
region. Using a simple analytical model, we show that the plasmoid ejection and
acceleration are closely coupled with the reconnection process, leading to a
nonlinear instability for the whole dynamics that determines the macroscopic
reconnection rate uniquely. Next we show that the current sheet tends to have a
fractal structure via the following process path: tearing, sheet thinning,
Sweet- Parker sheet, secondary tearing, further sheet thinning... These
processes occur repeatedly at smaller scales until a microscopic plasma scale
(either the ion Larmor radius or the ion inertial length) is reached where
anomalous resistivity or collisionless reconnection can occur. The current
sheet eventually has a fractal structure with many plasmoids (magnetic islands)
of different sizes. When these plasmoids are ejected out of the current sheets,
fast reconnection occurs at various different scales in a highly time dependent
manner. Finally, a scenario is presented for fast reconnection in the solar
corona on the basis of above plasmoid-induced-reconnection in a fractal current
sheet.Comment: 9 pages, 11 figures, with using eps.sty; Earth, Planets and Space in
press; ps-file is also available at
http://stesun8.stelab.nagoya-u.ac.jp/~tanuma/study/shibata2001
Evaluation of adenovirus capsid labeling versus transgene expression
Adenoviral vectors have been utilized for a variety of gene therapy applications. Our group has incorporated bioluminescent, fluorographic reporters, and/or suicide genes within the adenovirus genome for analytical and/or therapeutic purposes. These molecules have also been incorporated as capsid components. Recognizing that incorporations at either locale yield potential advantages and disadvantages, our report evaluates the benefits of transgene incorporation versus capsid incorporation. To this end, we have genetically incorporated firefly luciferase within the early region 3 or at minor capsid protein IX and compared vector functionality by means of reporter readout
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