4 research outputs found
Slime production and proteinase activity of Candida species isolated from blood samples and the comparison of these activities with minimum inhibitory concentration values of antifungal agents
Slime and proteinase activity of 54 strains consisting of 19 Candida
parapsilosis and 35 Candida albicans strains isolated
from blood samples were investigated in this study. Ketoconazole,
amphothericin B, and fluconazole susceptibility of Candida
species were compared with slime production and proteinase activity of
these species. For both Candida species, no correlation was detected
between the slime activity and minimum inhibitory concentration (MIC)
values of the three antifungal agents. For both Candida species no
correlation was detected between the proteinase activity and the MIC
values of amphothericin B, and fluconazole however, statistically
significant difference, was determined between the proteinase activity
and MIC values of ketoconazole (p = 0.007). Slime production was
determined by using modified Christensen macrotube method and
proteinase activity was measured by the method of Staib. Antifungal
susceptibility was determined through the guidelines of National
Committee for Laboratory Standards (NCCLS M27-A)