Copper-catalyzed site-selective direct arylation of triptycene

A site-selective direct CH arylation protocol for the triptycene skeleton is developed using copper catalyst and diaryliodonium reagents. With the aid of directing groups, C₃-symmetric trisubstituted triptycenes are selectively synthesized, and the structure was determined by X-ray diffraction analysis. Further derivatization of the installed bromo functionalities is also described

Electrophilic substitution of asymmetrically distorted benzenes within triptycene derivatives

Herein we disclose a unique directing effect of 9-substituted triptycenes in electrophilic substitution to achieve the regioselective functionalization of the triptycene core. The Hirshfeld population analysis was adopted to predict the selectivity in electrophilic substitution. TMS and t-Bu groups were found to considerably accelerate the reaction at C2 positions to produce C3-symmetric isomers. Correlation between distortion and charge distribution within benzene rings was systematically examined.Ueno K., Nishii Y., Miura M.. Electrophilic substitution of asymmetrically distorted benzenes within triptycene derivatives. Organic Letters. 23(9), 3552-3556, (2021), 7 May 2021; ©2021 American Chemical Society. https://doi.org/10.1021/acs.orglett.1c00970

H2O maser motions and the distance of the star forming region G192.16-3.84

We present the results of astrometic observations of H2O masers associated with the star forming region G192.16-3.84 with the VLBI Exploration of Radio Astrometry (VERA). The H2O masers seem to be associated with two young stellar objects (YSOs) separated by \sim1200 AU as reported in previous observations. In the present observations, we successfully detected an annual parallax of 0.66 \pm 0.04 mas for the H2 O masers, which corresponds to a distance to G192.16-3.84 of D = 1.52 \pm 0.08 kpc from the Sun. The determined distance is shorter than the estimated kinematic distance. Using the annual parallax distance and the estimated parameters of the millimeter continuum emission, we estimate the mass of the disk plus circumstellar cloud in the southern young stellar object to be 10.0+4.3M\cdot. We also estimate the galactocentric distance and the peculiar motion -3.6 of G192.16-3.84, relative to a circular Galactic rotation: R\star = 9.99 \pm 0.08 kpc, Z\star = -0.10 \pm 0.01 kpc, and (U\star,V\star,W\star)=(-2.8\pm1.0,-10.5\pm0.3,4.9\pm2.7)[kms-1]respectively. The peculiar motion of G192.16-3.84 is within that typically found in recent VLBI astrometric results. The angular distribution and three-dimensional velocity field of H2O maser features associated with the northern YSO indicate the existence of a bipolar outflow with a major axis along the northeast-southwest direction.Comment: 9 pages, 2 figures and 4 tables. Accepted for publication on PAS

Focal Myasthenia Gravis in Two Dogs

Two dogs were presented with history of regurgitation. Both dogs were diagnosed with focal myasthenia gravis (FMG). Thoracic radiography was consisted with megaesophagus. Acetylcholine receptors (AChRs) antibody titer was positive. Both dogs were treated with pyridostigmine bromide as sole treatment. One case rapidly resolved with the recovery of the esophagus, while the other case even the AChRs antibody titer was normalized after 60 days but the clinical remission was occurred after long time. This report suggested that clinical signs of FMG were resolved, but we can’t predict the time required, additionally, pyridostigmine bromide might be effective for palliation of symptoms