Evolution of Rotating Accreting White Dwarfs and the Diversity of Type Ia Supernovae

Type Ia supernovae (SNe Ia) have relatively uniform light curves and spectral evolution, which make SNe Ia useful standard candles to determine cosmological parameters. However, the peak brightness is not completely uniform, and the origin of the diversity has not been clear. We examine whether the rotation of progenitor white dwarfs (WDs) can be the important source of the diversity of the brightness of SNe Ia. We calculate the structure of rotating WDs with an axisymmetric hydrostatic code. The diversity of the mass induced by the rotation is ~0.08 Msun and is not enough to explain the diversity of luminosity. However, we found the following relation between the initial mass of the WDs and their final state; i.e., a WD of smaller initial mass will rotate more rapidly before the supernova explosion than that of larger initial mass. This result might explain the dependence of SNe Ia on their host galaxies.Comment: 7 pages, 6 figure

Ductility of interstitial-free steel under high strain rate tension: Experiments and macroscopic modeling with a physically-based consideration

AbstractIn this paper, an experimental investigation and a constitutive modeling of the mechanical response of an interstitial-free (IF) steel over a wide range of strain rates (from 0.001/s to 750/s) are presented. Tensile tests at relatively high strain rates, exceeding 100/s, are performed at an initial room temperature, using the so-called one bar technique developed on the basis of the Hopkinson bar method. At a high strain rate, a distinct upper yield limit is observed, and the subsequent flow stress increases remarkably. Furthermore, the ductility is reduced significantly in comparison to the case of low strain rate tension. In order to express such a complicated material response of IF steel, we develop a new constitutive model that takes into account effects of a change in the mobile dislocation density and thermal softening. The model can be easily applicable to large-scale engineering computations, because it is macroscopically formulated. We try to reproduce the tensile response including a diffuse neck formation at high strain rates, using the proposed constitutive model and finite element method. The results indicate that a change in the mobile dislocation density, together with thermal softening, has substantial effects on apparent work hardening behavior at high strain rates, although the change in the mobile dislocation density is transcribed at macroscopic scale in the model. Finally, we discuss characteristics of true stress–true strain curves at various strain rates, and their correlation with the plastic instability behavior

Polymorphisms in pattern recognition receptors and their relationship to infectious disease susceptibility in pigs

<p>Abstract</p> <p>Background</p> <p>Pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), are censoring receptors for molecules derived from bacteria, viruses, and fungi. The PRR system is a prerequisite for proper responses to pathogens, for example by cytokine production, resulting in pathogen eradication. Many cases of polymorphisms in PRR genes affecting the immune response and disease susceptibility are known in humans and mice.</p> <p>Methods</p> <p>We surveyed polymorphisms in pig genes encoding PRRs and investigated the relationship between some of the detected polymorphisms and molecular function or disease onset.</p> <p>Results</p> <p>Nonsynonymous polymorphisms abounded in pig TLR genes, particularly in the region corresponding to the ectodomains of TLRs expressed on the cell surface. Intracellular TLRs such as TLR3, TLR7, and TLR8, and other intracellular PRRs, such as the peptidoglycan receptor NOD2 and viral RNA receptors RIG-I and MDA5, also possessed nonsynonymous polymorphisms. Several of the polymorphisms influenced molecular functions such as ligand recognition. Polymorphisms in the PRR genes may be related to disease susceptibility in pigs: pigs with a particular allele of <it>TLR2</it> showed an increased tendency to contract pneumonia.</p> <p>Conclusions</p> <p>We propose the possibility of pig breeding aimed at disease resistance by the selection of PRR gene alleles that affect pathogen recognition.</p

Type Ia Supernovae: Progenitors and Diversities

A key question for supernova cosmology is whether the peak luminosities of Type Ia supernovae (SNe Ia) are sufficiently free from the effects of cosmic and galactic evolution. To answer this question, we review the currently popular scenario of SN Ia progenitors, i.e., the single degenerate scenario for the Chandrasekhar mass white dwarf (WD) models. We identify the progenitor's evolution with two channels: (1) the WD+RG (red-giant) and (2) the WD+MS (near main-sequence He-rich star) channels. The strong wind from accreting WDs plays a key role, which yields important age and metallicity effects on the evolution. We suggest that the variation of the carbon mass fraction $X$(C) in the C+O WD (or the variation of the initial WD mass) causes the diversity of SN Ia brightness. This model can explain the observed dependence of SNe Ia brightness on the galaxy types. We then predict how SN Ia brightness evolves along the redshift (with changing metallicity and age) for elliptical and spiral galaxies. Such evolutionary effects along the redshift can be corrected as has been made for local SNe Ia. We also touch on several related issues: (1) the abundance pattern of stars in dwarf spheroidal galaxies in relation to the metallicity effect on SNe Ia, (2) effects of angular momentum brought into the WD in relation to the diversities and the fate of double degenerates, and (3) possible presence of helium in the peculiar SN Ia 2000cx in relation to the sub-Chandrasekhar mass model.Comment: 13 pages. Invited Review published in "From Twilight to Highlight: The Physics of Supernovae," eds. W. Hillebrandt & B. Leibundgut, ESO/Springer Series "ESO Astrophysics Symposia" (Berlin: Springer) p.115--127 (2003

Formation and Degradation of Beta-casomorphins in Dairy Processing

Milk proteins including casein are sources of peptides with bioactivity. One of these peptides is beta-casomorphin (BCM) which belongs to a group of opioid peptides formed from b-casein variants. Beta-casomorphin 7 (BCM7) has been demonstrated to be enzymatically released from the A1 or B b-casein variant. Epidemiological evidence suggests the peptide BCM 7 is a risk factor for development of human diseases, including increased risk of type 1 diabetes and cardiovascular diseases but this has not been thoroughly substantiated by research studies. High performance liquid chromatography coupled to UV-Vis and mass spectrometry detection as well as enzyme–linked immunosorbent assay (ELISA) has been used to analyze BCMs in dairy products. BCMs have been detected in raw cow’s milk and human milk and a variety of commercial cheeses, but their presence has yet to be confirmed in commercial yoghurts. The finding that BCMs are present in cheese suggests they could also form in yoghurt, but be degraded during yoghurt processing. Whether BCMs do form in yoghurt and the amount of BCM forming or degrading at different processing steps needs further investigation and possibly will depend on the heat treatment and fermentation process used, but it remains an intriguing unknown

Trans-Species Polymorphism and Selection in the MHC Class II DRA Genes of Domestic Sheep

Highly polymorphic genes with central roles in lymphocyte mediated immune surveillance are grouped together in the major histocompatibility complex (MHC) in higher vertebrates. Generally, across vertebrate species the class II MHC DRA gene is highly conserved with only limited allelic variation. Here however, we provide evidence of trans-species polymorphism at the DRA locus in domestic sheep (Ovis aries). We describe variation at the Ovar-DRA locus that is far in excess of anything described in other vertebrate species. The divergent DRA allele (Ovar-DRA*0201) differs from the sheep reference sequences by 20 nucleotides, 12 of which appear non-synonymous. Furthermore, DRA*0201 is paired with an equally divergent DRB1 allele (Ovar-DRB1*0901), which is consistent with an independent evolutionary history for the DR sub-region within this MHC haplotype. No recombination was observed between the divergent DRA and B genes in a range of breeds and typical levels of MHC class II DR protein expression were detected at the surface of leukocyte populations obtained from animals homozygous for the DRA*0201, DRB1*0901 haplotype. Bayesian phylogenetic analysis groups Ovar-DRA*0201 with DRA sequences derived from species within the Oryx and Alcelaphus genera rather than clustering with other ovine and caprine DRA alleles. Tests for Darwinian selection identified 10 positively selected sites on the branch leading to Ovar-DRA*0201, three of which are predicted to be associated with the binding of peptide antigen. As the Ovis, Oryx and Alcelaphus genera have not shared a common ancestor for over 30 million years, the DRA*0201 and DRB1*0901 allelic pair is likely to be of ancient origin and present in the founding population from which all contemporary domestic sheep breeds are derived. The conservation of the integrity of this unusual DR allelic pair suggests some selective advantage which is likely to be associated with the presentation of pathogen antigen to T-cells and the induction of protective immunity