Management of hypertension with fixed dose combinations of candesartan cilexetil and hydrochlorothiazide: patient perspectives and clinical utility

Hypertension treatment and control is largely unsatisfactory when guideline-defined blood pressure goal achievement and maintenance are considered. Patient- and physician-related factors leading to non-adherence interfere in this respect with the efficacy, tolerability, and convenient use of pharmacological treatment options. Blockers of the renin–angiotensin system (RAS) are an important component of antihypertensive combination therapy. Thiazide-type diuretics are usually added to increase the blood pressure lowering efficacy. Fixed drug–drug combinations of both principles like candesartan/hydrochlorothiazide (HCTZ) are highly effective in lowering blood pressure while providing improved compliance, a good tolerability, and largely neutral metabolic profile. Comparative studies with losartan/HCTZ have consistently shown a higher clinical efficacy with the candesartan/HCTZ combination. Data on the reduction of cardiovascular endpoints with fixed dose combinations of antihypertensive drugs are however scarce, as are the data for candesartan/HCTZ. But many trials have tested candesartan versus a non-RAS blocking comparator based on a standard therapy including thiazide diuretics. The indications tested were heart failure and stroke and particular emphasis was put on elderly patients or those with diabetes. In patients with heart failure, for example, the fixed dose combination might be applied in patients in whom individual titration resulted in a dose of 32 mg candesartan and 25 mg HCTZ which can then be combined into one tablet to increase compliance with treatment. Also in patients with stroke the fixed dose combination might be used in patients in whom maintenance therapy with both components is considered. Taken together candesartan/HCTZ assist both physicians and patients in achieving long-term blood pressure goal achievement and maintenance

偷窺的幻想外遇 : 李翰祥鏡頭下的金‧瓶‧梅

提及李翰祥的風月片，總有評論家落入男性凝視（male gaze）的簡單批判。可見他們在李氏跨越七十至九十年代的《金瓶梅》風月片系列中，完全無視了女角色間的凝視、偷窺和偷聽。她們表面是忠於父權的妻子或僕人，暗地裡卻是偷窺得不亦樂乎繼而外遇的淫婦。李氏挪用原著的色情元素，以晚明資本主義下的道德失序，回應香港七十年代金錢至上、權威不受信任的意識。當時社會不再熱衷傳統倫理，投身於色情片熱潮中，因此觀眾享受的不單是李氏鏡頭下的美人，也是她們在凝視中拓展身分，主動開發情慾的反叛精神。她們甚至不怕男性凝視，最怕男性不凝視，因此搔首弄姿、嬌聲嬌氣，時而淫蕩，時而溫柔，讓至高無上的西門慶拜倒在她們裙下。 本文主要分析《風流韻事（蕙蓮篇）》（1973）、《金瓶雙艷》（1974）和《金瓶風月》（1991）中的四位女主角：金蓮、春梅、瓶兒和蕙蓮。探討李氏如何表現凝視間的陰性認同，並從女性間的認同分析她們對情慾的不同追求，如何（不）抗衡以西門作代表的父權，以一雙媚眼遊走於婚姻的曖昧地帶

PENINGKATAN HASIL BELAJAR SENAM RITMIK SI BUYUNG MENGGUNAKAN LAGU POTONG BEBEK ANGSA KELAS 1 SD NEGERI 1 NOTOG KECAMATAN PATIKRAJA KABUPATEN BANYUMAS TAHUN AJARAN 2016

The aim of this research was to determine the increase in the learning process and student learning outcomes in rhythmic activity of the pitcher using pieces of duck swan song for learners Class 1 SD Negeri 1 Notog Patikraja District of Banyumas. This type of research is a classroom action research. The subjects of this study is the first grade students of SD Negeri 1 Notog number of 23 students consisting of 14 boys and 9 female student. That the results of research activity in rhythmic gymnastics pitcher uses the song Cut Duck Goose Class 1 SD Negeri 1 Notog shows the increase of student learning from the first cycle (61%) to the second cycle (87%), it also means an increase of 26%. The conclusions in this research is the method of rhythmic gymnastics material Penjasorkes pitcher uses the song Cut Duck Goose can improve learning outcomes on student Penjasorkes Class 1 SD Negeri 1 Notog

Transport of the alpha subunit of the voltage gated Lâ type calcium channel through the sarcoplasmic reticulum occurs prior to localization to triads and requires the beta subunit but not Stac3 in skeletal muscles

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138228/1/tra12502-sup-0001-EditorialProcess.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138228/2/tra12502.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138228/3/tra12502_am.pd

Effects of Magnetic Field and Temperature on the Critical Current Hysteresis in Tl-Ca-Ba-Cu-O Thin Films

The behavior of the critical current density of Tl-Ca-Ba-Cu-O superconducting thin films in a cycling magnetic field was investigated. The hysteresis of the transport Jc manifested similar features to those found in polycrystalline Y-Ba-Cu-O and granular Nb, Al thin films in zero-field cooling. However, a novel result of the transport Jc in field-cooled samples has been observed. The results were attributed to the presence of a saturated trapped magnetic flux in the weaklink network. The effects of temperature on both the trapped flux and the transport Jc suggest the existence of various states of the trapped flux in the Tl-based superconducting thin films

Improving Detection Accuracy of Lung Cancer Serum Proteomic Profiling via Two-Stage Training Process

<p>Abstract</p> <p>Background</p> <p>Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS) is a frequently used technique for cancer biomarker research. The specificity of biomarkers detected by SELDI can be influenced by concomitant inflammation. This study aimed to increase detection accuracy using a two-stage analysis process.</p> <p>Methods</p> <p>Sera from 118 lung cancer patients, 72 healthy individuals, and 31 patients with inflammatory disease were randomly divided into training and testing groups by 3:2 ratio. In the training group, the traditional method of using SELDI profile analysis to directly distinguish lung cancer patients from sera was used. The two-stage analysis of distinguishing the healthy people and non-healthy patients (1^st-stage) and then differentiating cancer patients from inflammatory disease patients (2^nd-stage) to minimize the influence of inflammation was validated in the test group.</p> <p>Results</p> <p>In the test group, the one-stage method had 87.2% sensitivity, 37.5% specificity, and 64.4% accuracy. The two-stage method had lower sensitivity (> 70.1%) but statistically higher specificity (80%) and accuracy (74.7%). The predominantly expressed protein peak at 11480 Da was the primary splitter regardless of one- or two-stage analysis. This peak was suspected to be SAA (Serum Amyloid A) due to the similar m/z countered around this area. This hypothesis was further tested using an SAA ELISA assay.</p> <p>Conclusions</p> <p>Inflammatory disease can severely interfere with the detection accuracy of SELDI profiles for lung cancer. Using a two-stage training process will improve the specificity and accuracy of detecting lung cancer.</p