1 research outputs found
Supplementary Material for: Effect of Antithrombotic Therapy and Long Endoscopic Submucosal Dissection Procedure Time on Early and Delayed Postoperative Bleeding
<p><b><i>Background:</i></b> Recent updated guidelines of the Japanese
Society of Gastroenterology recommend the use of a single dose of
antiplatelet agents in patients undergoing endoscopic submucosal
dissection (ESD). However, the postoperative bleeding risk after gastric
ESD associated with the continuation or interruption of antithrombotic
therapy remains controversial. We aimed to evaluate whether certain
factors including interrupted antithrombotic therapy could affect early
and delayed post-ESD bleeding risk. <b><i>Methods:</i></b> Three hundred
sixty-four patients with gastric neoplasms were treated with ESD at our
hospital between October 2005 and December 2012. Seventy-four patients
with interrupted antithrombotic therapy were undertaken with ESD. Early
and delayed postoperative bleeding patterns were estimated. Various
clinical characteristics such as gender, age, tumor location, tumor
size, ESD procedure time, platelet count, and comorbidity were
evaluated. <b><i>Results:</i></b> There was a significant difference (<i>p</i>
= 0.042) in the ESD procedure time between the patients with
postoperative bleeding and those without it. There was no significant
difference in postoperative bleeding between the patients on
antithrombotic therapy and not on it. Moreover, interrupted
antithrombotic therapy and platelet count were significantly (<i>p</i> = 0.0461 and <i>p</i>
= 0.0059, respectively) associated with early postoperative bleeding in
multivariate analysis. In addition, in univariate analysis, ESD
procedure time was significantly (<i>p</i> = 0.041) associated with delayed postoperative bleeding. <b><i>Conclusions:</i></b>
Antithrombotic therapy and prolonged ESD procedure time were
significantly associated with early and delayed postoperative bleeding,
respectively.</p