Faculty Development and a Graduate Course for Pre-Service and In-Service Faculty: Finding and Enacting a Professional Identity in Basic Writing

This essay considers the critical need for pre-service and in-service basic writing faculty to define and enact a professional identity, specifically within the context of faculty development and graduate course settings. The essay describes a graduate course in teaching basic writing offered primarily online with four in-person weekend workshops. As a result, the course has faculty development implications. Key features of the class are professional mentoring through participation in the Council on Basic Writing discussion list, which offers visibility for students as emerging basic writing professionals; creation of Composition Frequently Asked Questions wiki material on basic writing, which serves as a kind of intermediary “publication”; and encouragement to present at conferences and submit manuscripts. The essay also explores the issue of faculty development generally for emerging and current basic writing professionals who are often working as contingent faculty and asks how a professional identity can be developed given these realities

Vacuum polarization induced by a uniformly accelerated charge

We consider a point charge fixed in the Rindler coordinates which describe a uniformly accelerated frame. We determine an integral expression of the induced charge density due to the vacuum polarization at the first order in the fine structure constant. In the case where the acceleration is weak, we give explicitly the induced electrostatic potential.Comment: 13 pages, latex, no figures, to appear in Int. J. Theor. Phys

Analytical formula for the Uehling potential

The closed analytical expression for the Uehling potential is derived. The Uehling potential describes the lowest-order correction on vacuum polarisation in atomic and muon-atomic systems. We also derive the analytical formula for the interaction potential between two electrically charged point particles which includes correction to the vacuum polarisation, but has correct asymptotic behaviour at larger $r$. Our three-term analytical formula for the Uehling potential opens a new avenue in the study of the vacuum polarisation in light atomic systems.Comment: arXiv admin note: substantial text overlap with arXiv:1103.204

Pion gas viscosity at low temperature and density

By using Chiral Perturbation Theory and the Uehling-Uhlenbeck equation we compute the viscosity of a pion gas, in the low temperature and low density regime, in terms of the temperature, and the pion fugacity. The viscosity turns out to be proportional to the squared root of the temperature over the pion mass. Next to leading corrections are proportional to the temperature over the pion mass to the 3/2.Comment: 15 pages, 4 figures. RevTeX

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma.

BackgroundLeiomyosarcoma (LMS) is a common type of soft tissue sarcoma that responds poorly to standard chemotherapy. Thus the goal of this study was to identify novel selective therapies that may be effective in leiomyosarcoma by screening cell lines with a small molecule library comprised of 480 kinase inhibitors to functionally determine which signalling pathways may be critical for LMS growth.MethodsLMS cell lines were screened with the OICR kinase library and a cell viability assay was used to identify potentially effective compounds. The top 10 % of hits underwent secondary validation to determine their EC50 and immunoblots were performed to confirm selective drug action. The efficacy of combination drug therapy with doxorubicin (Dox) in vitro was analyzed using the Calcusyn program after treatment with one of three dosing schedules: concurrent treatment, initial treatment with a selective compound followed by Dox, or initial treatment with Dox followed by the selective compound. Single and combination drug therapy were then validated in vivo using LMS xenografts.ResultsCompounds that targeted PI3K/AKT/mTOR pathways (52 %) were most effective. EC50s were determined to validate these initial hits, and of the 11 confirmed hits, 10 targeted PI3K and/or mTOR pathways with EC50 values <1 μM. We therefore examined if BEZ235 and BKM120, two selective compounds in these pathways, would inhibit leiomyosarcoma growth in vitro. Immunoblots confirmed on-target effects of these compounds in the PI3K and/or mTOR pathways. We next investigated if there was synergy with these agents and first line chemotherapy doxorubicin (Dox), which would allow for earlier introduction into patient care. Only combined treatment of BEZ235 and Dox was synergistic in vitro. To validate these findings in pre-clinical models, leiomyosarcoma xenografts were treated with single agent and combination therapy. BEZ235 treated xenografts (n = 8) demonstrated a decrease in tumor volume of 42 % whereas combining BEZ235 with Dox (n = 8) decreased tumor volume 68 % compared to vehicle alone.ConclusionsIn summary, this study supports further investigation into the use of PI3K and mTOR inhibitors alone and in combination with standard treatment in leiomyosarcoma patients

Small Effects in Astrophysical Fusion Reactions

We study the combined effects of vacuum polarization, relativity, Bremsstrahlung, and atomic polarization in nuclear reactions of astrophysical interest. It is shown that these effects do not solve the longstanding differences between the experimental data of astrophysical nuclear reactions at very low energies and the theoretical calculations which aim to include electron screening.Comment: 13 pages, 1 figur