Bmal1は細胞周期の調節を介して前立腺の増殖を制御する

京都大学新制・論文博士博士(医学)乙第13572号論医博第2298号京都大学大学院医学研究科医学専攻(主査)教授 藤田 恭之, 教授 武藤 学, 教授 伊藤 貴浩学位規則第4条第2項該当Doctor of Medical ScienceKyoto UniversityDFA

RESISTENZA ALLA CORROSIONE AD ALLA TENSOCORROSIONE DI ACCIAI BASSOLEGATI ED ACCIAI RESISTENTI ALLA CORROSIONE (CRAS) IN CONDIZIONI RAPPRESENTATIVE LA STIMOLAZIONE ACIDA

Nell’operazione di stimolazione acida negli impianti di estrazione di idrocarburi, sono necessari materiali altamente resistenti alla corrosione. In questo lavoro viene valutata la resistenza alla corrosione di acciai bassolegati, di acciai inossidabili martensitici e duplex, di leghe base Nichel, in alcune condizioni rappresentative la fase di ritorno degli acidi usati per la stimolazione dei pozzi, quali ad es in soluzioni di 28% HCl e 12% HCl + 3% HF in presenza di H2S e CO2 ad elevate temperature. Tutti i materiali testati per pH superiori a 4.0, hanno mostrato scarsa suscettibilità alla corrosione localizzata e alla tensocorrosione. L’acciaio superduplex e le leghe base nichel hanno mostrato un’elevata resistenza anche a pH inferiori a 3.5, mentre l’acciaio bassolegato T95e gli acciai martensitici hanno presentato tendenza alla corrosione generale e localizzata

Eosinophil Hyporesponse of Jirds Induced by Microfilariae of Brugia Pahangi

Male jirds (Meriones unguiculatus) were inoculated sc with 100 infective larvae of Brugia pahangi. After 16 weeks, the animals were reinoculated with a comparable number of organisms. Blood eosinophil responses during the 5 weeks subsequent to this attempt to reinfect were much lower than those of comparable naive animals, while the response to a heterologous infection (Toxocara canis) was comparable to that of controls. Mebendazole was given to infected animals for 2 weeks beginning 5 weeks (prepatent) or 16 weeks (patent) after infection. At comparable intervals after drug administration, the animals were reinoculated with infective larvae and the blood eosinophil response was measured over a 5 week period. The response in the animals treated during the prepatent period was higher than the untreated infected controls. Treatment during the patent period had no demonstrable effect. Jirds made artificially microfilaremic by intravenous inoculation of viable filaria before and after the standard infecting dose had a low eosinophil response to infective larvae

Macrophagic myofascitis associated with rheumatoid arthritis.

Macrophagic myofascitis (MMF) is an unusual inflammatory myopathy characterized by muscle infiltration by macrophages and lymphocytes. Here, we describe a case of MMF which is associated with rheumatoid arthritis. A 53-year-old Japanese rheumatoid arthritis (RA) patient presented with focal tenderness of lower extremities. Magnetic resonance imaging showed evidence of myofascitis involving fascias of anterior tibialis muscle. Muscle biopsy showed a unique pathological pattern of MMF. MMF is known to be associated with vaccination containing aluminum. However, our case was not related to aluminum containing vaccinations and etiologies are unknown. The possible link needs to be discussed