Synthesis of 1,2-dimethyl-6-(2' -hydroxyisopropyl)-7 -methoxynaphthalene, an isomer of emmotin-G methyl ether

857-86

FUNDUS AUTOFLUORESCENCE PREDICTING GROWTH OF A CHOROIDAL OSTEOMA IN A 13-YEAR-OLD GIRL

PURPOSE: To describe multimodal imaging findings, including fundus autofluorescence, in a patient with a growing choroidal osteoma. METHODS: Case report. RESULTS: A 13-year-old girl presented with an asymptomatic lesion in the superonasal macula of her left eye. Vision was correctable to 20/20 in both eyes, and the only significant finding on examination was the yellow flat lesion in the left macula. It measured 0.8-disk areas in size. Ocular coherence tomography showed a space occupying lesion in the choroid that had horizontal hyper-reflective lines consistent with cancellous bone. Re-examination in a year showed enlargement. Fundus autofluorescence showed no abnormalities in either eye. Ultrasonography showed a hyper-reflective lesion with associated shadowing that was consistent with a choroidal osteoma. CONCLUSION: Normal fundus autofluorescence was seen in this young girl with a growing choroidal osteoma. Fundus autofluorescence is a proxy for the health of the retinal pigment epithelium. Normal retinal pigment epithelium is the only factor found to be predictive of future growth of a choroidal osteoma. This noninvasive test may prove useful as a guide to determine frequency of examinations especially in younger patients who might be prone to more rapid growth.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal

Effect of intravitreal bevacizumab on the retina ganglion cell layer

Purpose: To investigate the effect of intravitreal (IV) bevacizumab on the ganglion cell layer (GCL) of patients with age-related macular degeneration (ARMD), diabetic macular edema (DME), and retinal vein occlusions (RVO). Methods: A total of 172 charts of patients who presented to the Henry Ford Health System in the year 2016 and received IV bevacizumab were reviewed. Patients who received other IV injections such as steroids, ranibizumab, or aflibercept, and patients who had retinal therapies such as laser or surgery were excluded. Patients were included if they had either ARMD, DME, or RVO including central retinal vein occlusion and branch retinal vein occlusion, and three injections. Both unilateral and bilateral involvement were included. Demographic data, as well as best-corrected visual acuity (BCVA), intraocular pressure (IOP), and GCL average volumes on presentation and after each of the three injections were collected. Changes in GCL volume compared to presentation, and the untreated eye if the condition is unilateral, were analyzed. Correlations between GCL and BCVA or IOP changes were also investigated. Comparisons between RVO, ARMD, and DME were also studied. Results: Fifty eyes from 25 patients were included. Eighteen patients had unilateral disease. There was a statistically significant decrease in GCL volume compared to the initial volume of the same eye after the second and third injections for all subjects. There was also a significant decrease in GCL volume compared to the contralateral eye after the second injection, but not after the third. IOP was inversely correlated with GCL volume after the first and second injection, but not the third. BCVA was inversely GCL volume after the second and third injection, though this varied between diagnoses; eyes with DME had a significant association after each injection; ARMD had a significant association only after the first injection, while RVO had no significant association after any injection. Conclusions: Use of IV bevacizumab has a trend toward greater interval thinning of the GCL in the treated eye, but compared to the untreated eye, this does not remain significant, implying this may be due to the underlying condition. The significance of correlation between improvement in vision and change in GCL volume after treatment varies depending on the condition being treated, suggesting that these diseases respond differently to bevacizumab

Roller coaster retinopathy: case report of symptomatic bilateral intraretinal hemorrhages after shaking injury in an otherwise healthy adult

PURPOSE: Traumatic head injuries not involving the eye have been known to cause retinal injury through multiple mechanisms. Abusive head trauma remains the prototypical example. We propose to demonstrate the first case of bilateral multiple retinal hemorrhages in a young healthy adult related to riding multiple theme park roller coasters. METHODS: The patient was evaluated with a complete ophthalmic examination including dilated extended ophthalmoscopy, fluorescein angiography, optical coherence tomography, and fundus photography. RESULTS: The patient was found to have a bilateral symptomatic macular retinopathy characterized by multiple intraretinal hemorrhages. Given the lack of other systemic findings and negative medical workup, her signs and symptoms were thought to be attributed to the same day attendance of a theme park and riding of multiple roller coasters. CONCLUSION: Theme park roller coasters, as well as other attractions, may affect the eye at the vitreoretinal interface. This type of acceleration-deceleration injury should be considered in the differential of an adolescent or adult patient with retinal hemorrhage in the absence of other pathologic processes to explain clinical findings

Valsalva-Like Retinopathy Secondary to Pancytopenia following Induction of Etoposide and Ifosfamide

Etoposide and ifosfamide are chemotherapeutic agents used frequently in the treatment of sarcomas and hematologic malignancies. Ocular side effects are rarely reported. We describe a case of a patient on etoposide and ifosfamide who presented with unilateral vision loss, anemia, and thrombocytopenia. The patient was found to have a large subinternal limiting membrane hemorrhage in the right eye that is thought to be related to his anemia and thrombocytopenia. The hemorrhage resolved spontaneously after 10 days. This case illustrates how bone marrow suppression by chemotherapeutic agents may indirectly contribute to retinal hemorrhages resulting in at least transient vision loss

Deuterium labelling studies with aliphatic amines

961-962<span style="font-size:12.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#242424;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">Alip<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#030303;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">h<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#242424;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">atic am<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#3d3d3d;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">i<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#242424;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">ne<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#3d3d3d;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">s <span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#242424;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">have been <span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#030303;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">l<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#242424;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">ab<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#3d3d3d;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">e<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#121212;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">ll<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#3d3d3d;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">e<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#242424;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">d at α<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#3d3d3d;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">- <span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:#242424;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">and β<span style="font-size:12.0pt;line-height:115%; font-family:" times="" new="" roman";mso-fareast-font-family:hiddenhorzocr;color:#242424;="" mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:hi"="" lang="EN-IN">-positions<span style="font-size:12.0pt;line-height:115%;font-family:HiddenHorzOCR;mso-hansi-font-family: " times="" new="" roman";mso-bidi-font-family:hiddenhorzocr;color:#3d3d3d;mso-ansi-language:="" en-in;mso-fareast-language:en-in;mso-bidi-language:hi"="" lang="EN-IN"> with deuterium using platinum-D2O. The deuterated amines have been examined by proton and deuterium NMR spectroscopy.</span

Comparative study of Heck reaction under thermal and microwave conditions

2235-2237Comparative study of Heck reaction of various substrates under thermal and microwave irradiation reveals advantage of microwave synthesis

Saturday Night Retinopathy: Characterization of a Rare Ophthalmic Condition

A 48-year-old, black female with a history of heroin and daily alcohol abuse presented to the emergency room in a lethargic state with severe right eye pain and vision loss. She had been unconscious for 10 hours prior to presentation. On exam she was found to have no light perception vision, severe retinal edema, and complete ophthalmoplegia of the right eye. Imaging and clinical course confirmed the diagnosis of Saturday Night Retinopathy--only the second documented case to be published