Diffusion-Weighted Imaging for the Discrimination of Benign and Malignant Breast Masses; Utility of ADC and Relative ADC

Purpose: To determine the contribution of apparent diffusion coefficient (ADC), and relative ADC (rADC) values to differentiate between benign and malignant breast masses. Materials and Methods: Magnetic resonance imaging (MRI) of the breast with diffusion-weighted imaging (DWI) of patients with benign or malignant breast masses diagnosed either by histopathological findings or by follow-up imaging were evaluated retrospectively. Histopathological analyses were performed for 71 lesions (80.7%) while the remaining were followed up every six months for one year. DWI was performed using b-values of 0 and 1000 sec/mm2, and ADC and rADC were calculated and compared. A receiver operating characteristic (ROC) curve and Youden index were used to evaluate the parameter’s optimal threshold and diagnostic value. Statistical significance was set as p < 0.05. Results: Eighty-eight lesions from a total of 81 patients, aged between 16 and 73 (mean age 42 ± 11.3) years were obtained and evaluated. Pathological results of 34 (38.6%) out of 71 lesions were malignant and 37 lesions (42%) were benign. Seventeen (19.3%) lesions remained stable at one-year follow-up and were accepted as benign breast masses. Mean ADC values of benign and malignant lesions were 1.584 × 10–3mm2/sec and 0.884 x 10–3mm2/sec (p < 0.05), respectively. Sensitivity and specificity of ADC were 88% and 87%, respectively at a cut-off value of 1.04 x 10–3mm2/sec. Mean rADC was 0.931 for benign lesions and 0.557 for malignant lesions (p < 0.05). Sensitivity and specificity were 82% and 83% at a cut-off value of 0.639. No prominent superiority of rADC over ADC is identified in the differentiation of breast masses. Conclusion: ADC and rADC values derived from DWI can be equally useful in clinical setting to differentiate benign from malignant breast masses

What can vestibular-evoked myogenic potentials tell us about vestibular schwannomas?

WOS:000607818400012A 27-year-old female presented with complaints of dizziness and tinnitus in the right ear. The neurological examination and the audiometry were completely normal. Ocular vestibular-evoked myogenic potential (oVEMP) obtained by the stimulation of the right ear was absent, whereas bilateral cervical VEMPs and left-sided oVEMP response were normal. With the absence of hearing loss and absent oVEMP on the affected side, the superior vestibular nerve involvement was decided. Magnetic resonance imaging revealed a vestibular schwannoma (VS) in the right cerebellopontine angle 32 mm x 31 mm in size. The patient was presented to show the contribution of cheap vestibular tests in the diagnosis of VSs as well as the prediction of the involved nerve. It was also interesting to see a tumor with a diameter exceeding 3 cm not causing hearing loss

Cervical Vestibular Evoked Myogenic Potentials in Idiopathic Intracranial Hypertension

Purpose: Idiopathic intracranial hypertension (IIH) is raised intracranial pressure without any identifiable etiology. The inner ear structures are susceptible to cerebrospinal fluid (CSF) pressure changes because of connections between the CSF space and the labyrinth to explain the audiovestibular symptoms, such as pulsatile tinnitus or dizziness, reported in 50% to 60% of these patients. The aim of this study was to investigate the vestibular functions using cervical vestibular evoked myogenic potentials (cVEMPs) in IIH. Methods: cVEMPs were recorded in 30 patients with IIH before lumbar puncture. Thirty healthy volunteers constituted the control group. The latencies of peaks p13 and n23 and peak-to-peak amplitude of p13-n23 were measured. Results: Responses were gathered bilaterally from all healthy controls. In 30 patients with IIH, 49 responses could be gathered from 60 tests (81.7%). The potential was absent bilaterally in five and unilaterally in one patient. When recorded, the latency and amplitude values of the responses of the patients were not significantly different from the healthy controls (P > 0.005). A correlation between CSF pressure and response persistence could not be determined. Conclusions: cVEMPs are affected in patients with IIH and the main finding is the absence of the responses. Increased intracranial pressure causing sound transmission changes within the inner ear can affect the saccular afferents and may end up with absent responses on air-conducted cVEMP recordings. To comment on the correlation between the CSF pressure and cVEMP changes, successive cVEMP recordings with longitudinal CSF pressure monitoring seem necessary

CERVICAL VESTIBULAR EVOKED MYOGENIC POTENTIALS IN IDIOPATHIC INTRACRANIAL HYPERTENSION

Migraine Trust Virtual International Symposium (MTIS) -- OCT 03-09, 2020 -- ELECTR NETWORKWOS: 000581847000120[No abstract available

The correlation between biological activity and diffusion-weighted MR imaging and ADC value in cases with prostate cancer

Purpose: Firstly, we aimed to investigate the correlation among dynamic contrasted magnetic resonance (MR) images, diffusion-weighted MR images, and apparent diffusion coefficent (ADC) values in patients with prostate cancer. Secondly, we aimed to investigate the roles of these variables on clinical risk classification and the biological behavior of the prostate cancer. Methods: A total of sixty with prostatic adenocarcinoma patients diagnosed between January 2011 and May 2013 were retrospectively included in the study. Risk classification of patients were evaluated as low-risk (Group 1) (n = 20) (Stage T1c-T2a, PSA T3a, PSA > 20 ng/ml, Gleason Score > 7). Diffusion-weighted MR images, dynamic contrasted MR images, and ADC values of the prostates were correlated. Results: ADC values of the cases in Group 3 were lower than those of the other groups (p 0.05). Biological activity of the tumor tissue was determined by GS, while a negative correlation was observed between GSs and ADC values of the patients, (p < 0.001). Conclusion: In tumors with higher Gleason scores, lower ADC values were obtained. These measured values can play a role in the noninvasive determination of the cellularity of the tumoral mass

MRI Radiomics of Breast Cancer: Machine Learning-Based Prediction of Lymphovascular Invasion Status

Rationale and Objectives: In patients with breast cancer (BC), lymphovascular invasion (LVI) status is considered an important prognostic factor. We aimed to develop machine learning (ML)-based radiomics models for the prediction of LVI status in patients with BC, using preoperative MRI images

Radioproteomics in Breast Cancer: Prediction of Ki-67 Expression With MRI-based Radiomic Models

Rationale and Objectives: We aimed to investigate the value of magnetic resonance image (MRI)-based radiomics in predicting Ki-67 expression of breast cancer

Evaluation of the Appearance Characteristics of Suspicious Microcalcifications Detected by Ultrasonography

Objective: To investigate the imaging properties of mammographically suspicious microcalcifications (MC) that can be detected by ultrasonography (USG)

Could Chest Computed Tomography Scores Assess the Inflammatory Markers and Disease Severity of Coronavirus Disease-2019 Patients?

Objective: This study aimed to investigate the relationship between chest computed tomography (CT) scores and inflammatory markers in patients with coronavirus disease-2019 (COVID-19)