7 research outputs found
An investigation of the effect of radioactive labeling of DNA on excision repair in UV-irradiated human fibroblasts
An Analysis of the Interaction between Two Nitrosourea Compounds and X-radiation in Rat Brain Tumour Cells
Cell Death, Chromosome Damage and Mitotic Delay in Normal Human, Ataxia Telangiectasia and Retinoblastoma Fibroblasts after X-irradiation
Treatment of behavioural symptoms and dementia in Parkinson's disease
Behavioural symptoms such as anxiety, depression and psychosis are common in Parkinson's disease (PD), and dementia occurs in about 90% of the patients. These symptoms can be more disabling than the motor dysfunction and they negatively impact quality of life, increase caregiver distress and are more frequently associated with nursing home placement. Depression can be treated with counselling and pharmacotherapy. Tricyclic antidepressants or selective serotonin reuptake inhibitors are widely used, but there is still need for controlled clinical trials. Management of psychosis in PD is complex and includes elimination of identifiable risk factors, reduction of polypharmacy and administration of atypical neuroleptics, which can alleviate psychotic symptoms without worsening motor functions. Clozapine is the best documented atypical neuroleptic shown to be effective against psychosis in PD patients. Cholinesterase inhibitors may prove additional benefit in psychotic PD patients. Recent evidence from small double-blind and open-label trials suggests that cholinesterase inhibitors may be effective in the treatment of dementia associated with PD