Systems analysis of iron metabolism: the network of iron pools and fluxes

<p>Abstract</p> <p>Background</p> <p>Every cell of the mammalian organism needs iron as trace element in numerous oxido-reductive processes as well as for transport and storage of oxygen. The very versatility of ionic iron makes it a toxic entity which can catalyze the production of radicals that damage vital membranous and macromolecular assemblies in the cell. The mammalian organism maintains therefore a complex regulatory network of iron uptake, excretion and intra-body distribution. Intracellular regulation in different cell types is intertwined with a global hormonal signalling structure. Iron deficiency as well as excess of iron are frequent and serious human disorders. They can affect every cell, but also the organism as a whole.</p> <p>Results</p> <p>Here, we present a kinematic model of the dynamic system of iron pools and fluxes. It is based on ferrokinetic data and chemical measurements in C57BL6 wild-type mice maintained on iron-deficient, iron-adequate, or iron-loaded diet. The tracer iron levels in major tissues and organs (16 compartment) were followed for 28 days. The evaluation resulted in a whole-body model of fractional clearance rates. The analysis permits calculation of absolute flux rates in the steady-state, of iron distribution into different organs, of tracer-accessible pool sizes and of residence times of iron in the different compartments in response to three states of iron-repletion induced by the dietary regime.</p> <p>Conclusions</p> <p>This mathematical model presents a comprehensive physiological picture of mice under three different diets with varying iron contents. The quantitative results reflect systemic properties of iron metabolism: dynamic closedness, hierarchy of time scales, switch-over response and dynamics of iron storage in parenchymal organs.</p> <p>Therefore, we could assess which parameters will change under dietary perturbations and study in quantitative terms when those changes take place.</p

Improved Measurements of Branching Fractions and CP Asymmetries in B-> eta h Decays

We report improved measurements of B decays with an eta meson in the final state using 492 fb^{-1} of data collected by the Belle detector at the KEKB e^+ e^- collider. We observe the decays B^{+-}-> eta pi^{+-} and B^{+-}-> eta K^{+-}; the measured branching fractions are Br(B^{+-}-> eta pi^{+-}) = (4.2+- 0.4(stat)+- 0.2(sys))x10^{-6} and Br(B^{+-}-> eta K^{+-}) = (1.9+-0.3(stat)^{+0.2}_{-0.1}(sys))x10^{-6}. The corresponding CP-violating asymmetries are measured to be -0.23+- 0.09(stat) +-0.02(sys) for eta pi^{+-} and -0.39+-0.16(stat)+-0.03(sys) for eta K^{+-}. We also search for B^0-> eta K^0 decays and set an upper limit of 1.9x10^{-6} at the 90% confidence level.Comment: 7 pages, 3 figure

Breakup reaction models for two- and three-cluster projectiles

Breakup reactions are one of the main tools for the study of exotic nuclei, and in particular of their continuum. In order to get valuable information from measurements, a precise reaction model coupled to a fair description of the projectile is needed. We assume that the projectile initially possesses a cluster structure, which is revealed by the dissociation process. This structure is described by a few-body Hamiltonian involving effective forces between the clusters. Within this assumption, we review various reaction models. In semiclassical models, the projectile-target relative motion is described by a classical trajectory and the reaction properties are deduced by solving a time-dependent Schroedinger equation. We then describe the principle and variants of the eikonal approximation: the dynamical eikonal approximation, the standard eikonal approximation, and a corrected version avoiding Coulomb divergence. Finally, we present the continuum-discretized coupled-channel method (CDCC), in which the Schroedinger equation is solved with the projectile continuum approximated by square-integrable states. These models are first illustrated by applications to two-cluster projectiles for studies of nuclei far from stability and of reactions useful in astrophysics. Recent extensions to three-cluster projectiles, like two-neutron halo nuclei, are then presented and discussed. We end this review with some views of the future in breakup-reaction theory.Comment: Will constitute a chapter of "Clusters in Nuclei - Vol.2." to be published as a volume of "Lecture Notes in Physics" (Springer

Measurements of exclusive B_s^0 decays at the Y(5S) resonance

Several exclusive $B_s^0$ decays are studied using a 1.86 fb-1 data sample collected at the Y(5S) resonance with the Belle detector at the KEKB asymmetric energy e^+ e^- collider. In the $B_s^0 \to D_s^- \pi^+$ decay mode we find 10 $B_s^0$ candidates and measure the corresponding branching fraction. Combining the B_s^0 -> D_s^{(*)-} \pi^+, B_s^0 -> D_s^{(*)-} \rho^+, B_s^0 -> J/\psi \phi and B_s^0 -> J/\psi \eta decay modes, a significant $B_s^0$ signal is observed. The ratio \sigma (e^+ e^- -> B_s^* \bar{B}_s^*) / \sigma (e^+ e^- -> B_s^{(*)} \bar{B}_s^{(*)}) = (93^{+7}_{-9} \pm 1)% is obtained at the Y(5S) energy, indicating that $B_s^0$ meson production proceeds predominantly through the creation of $B^*_s \bar{B}^*_s$ pairs. The $B_s^0$ and $B_s^*$ meson masses are measured to be M(B_s^0)=(5370 \pm 1 \pm 3)MeV/c^2 and M(B_s^*)=(5418 \pm 1 \pm 3)MeV/c^2. Upper limits on the B_s^0 -> \gamma \gamma, B_s^0 -> \phi \gamma, B_s^0 -> K^+ K^- and B_s^0 -> D_s^{(*)+} D_s^{(*)-} branching fractions are also reported.Comment: 9 pages, 5 figures, published in Phys. Rev. D76, 012002 (2007

Study of time-dependent CP violation in B0 -> J/Psi pi0 decays

We report a measurement of CP asymmetry parameters in the decay B0(B0bar) -> J/Psi pi0, which is governed by the b->c cbar d transition. The analysis is based on a 140/fb data sample accumulated at the Upsilon(4S) resonance by the belle detector at the KEKB asymmetric-energy e+e- collider. We fully reconstruct one neutral B meson in the J/Psi pi0 final state. The accompanying B meson flavor is identified by its decay products. From the distribution of proper time intervals between the two B decays, we obtain the following CP-violating parameters: S_{J/Psi pi0}=-0.72+-0.42+-0.09 and A_{J/Psi pi0}=-0.01 +-0.29+-0.03.Comment: 5 pages, 2 figures, submitted to PR

Search for B+ -> D*+ pi0 decay

We report on a search for the doubly Cabibbo suppressed decay B+ -> D*+ pi0, based on a data sample of 657 million BBbar pairs collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric energy e+ e- collider. We find no significant signal and set an upper limit of Br(B+ -> D*+ pi0) < 3.6 x 10^-6 at the 90% confidence level. This limit can be used to constrain the ratio between suppressed and favored B -> D* pi decay amplitudes, r < 0.051, at the 90% confidence level.Comment: 5pages, 2figures, submitted to PRL (v1); PRL published version (v2: minor corrections in the text

Search for Resonant B±→K±h→K±γγB^{\pm}\to K^{\pm} h \to K^{\pm} \gamma \gamma Decays at Belle

We report measurements and searches for resonant $B^{\pm} \to K^{\pm} h \to K^{\pm} \gamma \gamma$ decays where $h$ is a $\eta,\eta^{\prime},\eta_{c},\eta_{c}(2S),\chi_{c0},\chi_{c2},J/\psi$ meson or the X(3872) particle.Comment: accepted by Physics Letters

Study of CP Violating Effects in Time Dependent B0(B0ˉ)→D(∗)∓π±B^0(\bar{B^0}) \to D^{(*)\mp}\pi^{\pm} Decays

We report measurements of time dependent decay rates for $B^0(\bar{B}^0) \to D^{(*)\mp}\pi^{\pm}$ decays and extraction of CP violation parameters containing $\phi_3$. Using fully reconstructed $D^{(*)}\pi$ events from a $140 {\rm fb}^{-1}$ data sample collected at the $\Upsilon(4S)$ resonance, we obtain the CP violation parameters for $D^* \pi$ and $D \pi$ decays, $2R_{D^{(*)} \pi} \sin (2\phi_1 + \phi_3 \pm \delta_{D^{(*)} \pi})$, where $R_{D^{(*)} \pi}$ is the ratio of the magnitudes of the doubly-Cabibbo-suppressed and Cabibbo-favoured amplitudes, and $\delta_{D^{(*)} \pi}$ is the strong phase difference between them. Under the assumption of $\delta_{D^{(*)} \pi}$ being close to either 0 or $180^{\circ}$, we obtain $|2R_{D^* \pi} \sin (2\phi_1 + \phi_3)| = 0.060 \pm 0.040(\mathrm{stat}) \pm 0.019(\mathrm{sys})$ and $|2R_{D \pi} \sin (2\phi_1 + \phi_3)| = 0.061 \pm 0.037(\mathrm{stat}) \pm 0.018(\mathrm{sys})$.Comment: 9 pages, 3 figures, Submitted to Physical Review Letter

Evidence of time-dependent CP violation in the decay B0 to D*+D*-

We report a measurement of the CP-odd fraction and the time-dependent CP violation in B0 to D*+D*- decays, using 657.10^6 BBbar events collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider. We measure a CP-odd fraction of Rperp=0.125+/-0.043(stat)+/-0.023(syst). From the distributions of the proper-time intervals between a B0to D*+D*- decay and the other B meson in the event, we obtain evidence of CP violation with measured parameters AD*+D*-=0.15+/-0.13(stat)+/-0.04(syst) and SD*+D*-=-0.96+/-0.25(stat)-0.16+0.13(syst).Comment: Published in PR

Observation of b --> d gamma and Determination of |V_td/V_ts|

We report the observation of the flavor-changing neutral current process b --> d gamma using a sample of 386*10^6 B meson pairs accumulated by the Belle detector at the KEKB e+ e- collider. We measure branching fractions for the exclusive modes B- --> rho- gamma, B0bar --> rho0 gammaand B0bar --> omega gamma. Assuming that these three modes are related by isospin, we find Br(B --> (rho,omega) gamma) = (1.32 +0.34-0.31(stat.) +0.10-0.09(syst.)) * 10^-6 with a significance of 5.1 sigma. This result is used to determine the ratio of CKM matrix elements |V_td/V_ts| to be 0.199 +0.026-0.025(exp.) +0.018-0.015(theo.).Comment: 5 pages, 2 figures, submitted to Physical Review Letter