Percutaneous Ventricular Restoration (PVR) Therapy Using the Parachute Device in 100 Subjects with Ischaemic Dilated Heart Failure: One-Year Primary Endpoint Results of PARACHUTE III, a European Trial

AIMS: This prospective, non-randomised, observational study conducted in Europe was designed in order to assess the long-term safety and efficacy of the Parachute device in ischaemic heart failure subjects as a result of left ventricle remodelling after anterior wall myocardial infarction. METHODS AND RESULTS: One hundred subjects with New York Heart Association Class II-IV ischaemic heart failure (HF), ejection fraction (EF) between 15% and 40%, and dilated akinetic or dyskinetic anterior-apical wall without the need to be revascularised were enrolled. The primary safety endpoint was procedural- or device-related major adverse cardiac cerebral events (MACCE). The secondary safety endpoint was the composite of mortality and morbidity. Secondary efficacy endpoints included haemodynamic measurements determined by echocardiography, LV volume indices, and assessment of functional improvement measured by a standardised six-minute walk test. Of the 100 subjects enrolled, device implantation was successful in 97 (97%) subjects. The one-year rates of the primary and secondary safety endpoints were 7% and 32.3%, respectively. The secondary endpoints, LV volume reduction (p<0.0001) and six-minute walk distance improvement (p<0.01), were achieved. CONCLUSIONS: The favourable outcomes observed in this high-risk population provide reassuring safety and efficacy data to support adoption of this technology as a therapeutic option for HF subjects.info:eu-repo/semantics/publishedVersio

Das komplexe Beckentrauma: Matching des Beckenregisters DGU mit dem TraumaRegister DGU®

BACKGROUND Complex pelvic traumas, i.e., pelvic fractures accompanied by pelvic soft tissue injuries, still have an unacceptably high mortality rate of about 18 %. PATIENTS AND METHODS We retrospectively evaluated an intersection set of data from the TraumaRegister DGU® and the German Pelvic Injury Register from 2004-2009. Patients with complex and noncomplex pelvic traumas were compared regarding their vital parameters, emergency management, stay in the ICU, and outcome. RESULTS From a total of 344 patients with pelvic injuries, 21 % of patients had a complex and 79 % a noncomplex trauma. Complex traumas were significantly less likely to survive (16.7 % vs. 5.9 %). Whereas vital parameters and emergency treatment in the preclinical setting did not differ substantially, patients with complex traumas were more often in shock and showed acute traumatic coagulopathy on hospital arrival, which resulted in more fluid volumes and transfusions when compared to patients with noncomplex traumas. Furthermore, patients with complex traumas had more complications and longer ICU stays. CONCLUSION Prevention of exsanguination and complications like multiple organ dysfunction syndrome still pose a major challenge in the management of complex pelvic traumas

Intervention effects and long-term changes in physical activity and cardiometabolic outcomes among children at risk of noncommunicable diseases in South Africa: a cluster-randomized controlled trial and follow-up analysis

INTRODUCTION: Risk factors for noncommunicable diseases such as insufficient physical activity (PA), overweight or hypertension are becoming increasingly predominant among children globally. While school-based interventions are promising preventive strategies, evidence of their long-term effectiveness, especially among vulnerable populations, is scarce. We aim to assess the short-term effects of the physical and health KaziKidz intervention on cardiometabolic risk factors and the long-term, pre-and post-COVID-19 pandemic changes thereof in high-risk children from marginalized communities. METHODS: The intervention was tested in a cluster-randomized controlled trial between January and October 2019 in eight primary schools near Gqeberha, South Africa. Children with overweight, elevated blood pressure, pre-diabetes, and/or borderline dyslipidemia were identified and re-assessed 2 years post-intervention. Study outcomes included accelerometry-measured PA (MVPA), body mass index (BMI), mean arterial pressure (MAP), glucose (HbA1c), and lipid levels (TC to HDL ratio). We conducted mixed regression analyses to assess intervention effects by cardiometabolic risk profile, and Wilcoxon signed-rank tests to evaluate longitudinal changes in the high-risk subpopulation. RESULTS: We found a significant intervention effect on MVPA during school hours for physically inactive children, and among active as well as inactive girls. In contrast, the intervention lowered HbA1c and TC to HDL ratio only in children with glucose or lipid values within the norm, respectively. At follow-up, the intervention effects were not maintained in at-risk children, who showed a decline in MVPA, and an increase in BMI-for-age, MAP, HbA1c and TC to HDL ratio. CONCLUSION: We conclude that schools are key settings in which to promote PA and improve health; however, structural changes are necessary to ensure that effective interventions reach marginalized school populations and achieve sustainable impact

A Search for Muon-neutrino to Electron-neutrino and Muon-antineutrino to Electron-antineutrino Oscillations at NuTeV

Limits on $\nu_\mu \to \nu_e$ and $\bar\nu_\mu \to \bar\nu_e$ oscillations are extracted using the NuTeV detector with sign-selected $\nu_\mu$ and \nub_\mu beams. In \nub_\mu mode, for the case of $\sin^2 2\alpha = 1$, $\Delta m^2 > 2.6$ ${\rm eV^2}$ is excluded, and for $\Delta m^2 \gg 1000$ ${\rm eV^2}$, $\sin^2 2\alpha > 1.1 \times 10^{-3}$. The NuTeV data exclude the high $\Delta m^2$ end of $\bar\nu_\mu \to \bar\nu_e$ oscillations parameters favored by the LSND experiment without the need to assume that the oscillation parameters for $\nu$ and \nub are the same. We present the most stringent experimental limits for $\nu_\mu (\bar{\nu}_\mu) \to \nu_e (\bar{\nu}_e)$ oscillations in the large $\Delta m^2$ region.Comment: 4 pages, 3 figures. Submitted to Phys. Rev. Letters, UR-164

A Precise Determination of Electroweak Parameters in Neutrino-Nucleon Scattering

The NuTeV collaboration has extracted sin^2theta_W from the ratios of neutral current to charged current neutrino and anti-neutrino cross-sections. Our value, sin^2theta_W(on-shell)=0.2277+/-0.0013(stat)+/-0.0009(syst), is three standard deviations above the standard model prediction. We also present a model independent analysis of the same data.Comment: ReVTeX, 5 pp, 1fig; v2. revised SM prediction; v3. more sig. digits in Eqns 6-7, fix error in Eqn

Extraction of R = sigma_L/sigma_T from CCFR nu_mu-Fe and nubar_mu-Fe differential cross sections

We report on the extraction of R=sigma_L/sigma_T from CCFR nu_mu-Fe and nubar_mu-Fe differential cross sections. The CCFR differential cross sections do not show the deviations from the QCD expectations that are seen in the CDHSW data at very low and very high x. R as measured in nu_mu scattering is in agreement with R as measured in muon and electron scattering. All data on R for Q^2 > 1 GeV^2 are in agreement with a NNLO QCD calculation which includes target mass effects. We report on the first measurements of R in the low x and Q^2 < 1 GeV^2 region (where an anomalous large rise in R for nuclear targets has been observed by the HERMES collaboration).Comment: 4 pages, 4 figures, submitted to Phys. Rev. Let