Internal scheme of the body assessment in an experiment with environmental uncertainty

The aim of the work was to analyze the influence of various environmental factors forming environmental uncertainty on the nature of the transformation of the "internal scheme of the body". Materials and methods. For the study, a group of healthy volunteers (n = 90) was selected. The results in this paper are median, 75 and 25 percentiles (Me [UQ / LQ]). The study was conducted in several stages. At the first stage, the criteria for excluding potential participants from the experiment were formed. At the second stage of the study, a video analysis of the main anatomical orientations of the pelvic region in static and dynamic samples was conducted for all participants. Conclusion. In the course of the study, specific patterns of spatial deviations of biomechanical blocks of the pelvic region were established, triggered by changes in the qualitative and quantitative parameters of the external environment. So, in conditions of static equilibrium, coordination is activated with involvement of the anterior and posterior half-rings of the pelvis (frontal biomechanical blocks); in conditions of dynamic equilibrium, diagonal biomechanical blocks of the pelvic region are activated; in conditions of deprivation of visual afferentation, the compensatory reactions of the lateral semirings of the pelvic region (lateral biomechanical blocks) are formed

“CYTOKINE” MODEL OF PATHOGENESIS OF CHRONIC HEART FAILURE AND THE OPPORTUNITIES OF NEW THERAPEUTIC STRATEGY IN DECOMPENSATED PATIENTS

Neurohumoral model of pathogenesis of chronic heart failure (CHF) made it possible to develop new therapeutic approaches in patients with CHF . However , it became obvious that the ways of activation of neurohumoral systems in CHF are much more complicated. The increase in local synthesis of hormones causes the activation of inflammatory cytokines and protooncogenes, which have various negative effects. This allowed formulating immunoinflammatory conception of CHF pathogenesis, according to which the increase in interleukine-6 blood level is the marker of unfavorable prognosis for CHF , and the level of tumor necrosis factor-α (TNF-α) straightly correlates with severity of clinical condition and neurohumoral activity in CHF . The growth of TNF-α in CHF progressing as well as its reduction in successful treatment do not exclude the probability of positive effect of therapy , focused on the reduction of TNF-α concentration. The pathogenesis peculiarities of CHF including cytokine aggression demand the necessity of development of new therapy approaches with the use of cytokine system modulators