189 research outputs found

    f(R) theories

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    Over the past decade, f(R) theories have been extensively studied as one of the simplest modifications to General Relativity. In this article we review various applications of f(R) theories to cosmology and gravity - such as inflation, dark energy, local gravity constraints, cosmological perturbations, and spherically symmetric solutions in weak and strong gravitational backgrounds. We present a number of ways to distinguish those theories from General Relativity observationally and experimentally. We also discuss the extension to other modified gravity theories such as Brans-Dicke theory and Gauss-Bonnet gravity, and address models that can satisfy both cosmological and local gravity constraints.Comment: 156 pages, 14 figures, Invited review article in Living Reviews in Relativity, Published version, Comments are welcom

    Exactly Soluble Sector of Quantum Gravity

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    Cartan's spacetime reformulation of the Newtonian theory of gravity is a generally-covariant Galilean-relativistic limit-form of Einstein's theory of gravity known as the Newton-Cartan theory. According to this theory, space is flat, time is absolute with instantaneous causal influences, and the degenerate `metric' structure of spacetime remains fixed with two mutually orthogonal non-dynamical metrics, one spatial and the other temporal. The spacetime according to this theory is, nevertheless, curved, duly respecting the principle of equivalence, and the non-metric gravitational connection-field is dynamical in the sense that it is determined by matter distributions. Here, this generally-covariant but Galilean-relativistic theory of gravity with a possible non-zero cosmological constant, viewed as a parameterized gauge theory of a gravitational vector-potential minimally coupled to a complex Schroedinger-field (bosonic or fermionic), is successfully cast -- for the first time -- into a manifestly covariant Lagrangian form. Then, exploiting the fact that Newton-Cartan spacetime is intrinsically globally-hyperbolic with a fixed causal structure, the theory is recast both into a constraint-free Hamiltonian form in 3+1-dimensions and into a manifestly covariant reduced phase-space form with non-degenerate symplectic structure in 4-dimensions. Next, this Newton-Cartan-Schroedinger system is non-perturbatively quantized using the standard C*-algebraic technique combined with the geometric procedure of manifestly covariant phase-space quantization. The ensuing unitary quantum field theory of Newtonian gravity coupled to Galilean-relativistic matter is not only generally-covariant, but also exactly soluble.Comment: 83 pages (TeX). A note is added on the early work of a remarkable Soviet physicist called Bronstein, especially on his insightful contribution to "the cube of theories" (Fig. 1) -- see "Note Added to Proof" on pages 71 and 72, together with the new references [59] and [61

    The electroretinogram:a useful tool for evaluating age-related macular disease?

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    With an ageing population, the number of age-related macular disease (ARMD) cases will inevitably rise. This gives greater impetus for the need to identify the disease earlier and assess treatments to slow disease progression. Differing electroretinogram (ERG) modalities have been reviewed in relation to the objective assessment of retinal function in ARMD and for monitoring the effectiveness of clinical interventions. Conflicting results have been found with regard to the efficacy of ERG findings in the investigation of ARMD in previous years. The newer multifocal ERG paradigm provides spatial topographical information about retinal function in ARMD. It has shown promising results in monitoring effectiveness of clinical interventions and studies are continuing in this area. Better knowledge of retinal function in ARMD may lead to enhanced treatments at each phase of the disease

    Predicting DNA-Binding Specificities of Eukaryotic Transcription Factors

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    Today, annotated amino acid sequences of more and more transcription factors (TFs) are readily available. Quantitative information about their DNA-binding specificities, however, are hard to obtain. Position frequency matrices (PFMs), the most widely used models to represent binding specificities, are experimentally characterized only for a small fraction of all TFs. Even for some of the most intensively studied eukaryotic organisms (i.e., human, rat and mouse), roughly one-sixth of all proteins with annotated DNA-binding domain have been characterized experimentally. Here, we present a new method based on support vector regression for predicting quantitative DNA-binding specificities of TFs in different eukaryotic species. This approach estimates a quantitative measure for the PFM similarity of two proteins, based on various features derived from their protein sequences. The method is trained and tested on a dataset containing 1 239 TFs with known DNA-binding specificity, and used to predict specific DNA target motifs for 645 TFs with high accuracy

    Beam-induced backgrounds measured in the ATLAS detector during local gas injection into the LHC beam vacuum

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    Search for non-resonant Higgs boson pair production in final states with leptons, taus, and photons in pp collisions at s \sqrt{s} = 13 TeV with the ATLAS detector

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    Accuracy versus precision in boosted top tagging with the ATLAS detector

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    Search for heavy Majorana neutrinos in e±e± and e±μ± final states via WW scattering in pp collisions at s=13 TeV with the ATLAS detector

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