25 research outputs found
Enlargement of GAD-immunopositive terminals in the
Reorganization of cerebellar circuitry due to
specific cell loss in Weaver mutants causes physiological
and morphological alterations in the terminal domains of
the GABAergic cerebellar corticovestibular projections.
In this study sizes of anti-GAD immunopositive
terminals in the dorsal part of the lateral vestibular
nucleus (dLVN) of normal mice and Weaver mutants
were quantified morphometrically. In anti-GADimmunoreacted
material terminal sizes in the dLVN of
Weaver exceed significantly those of coprocessed
wildtypes. This suggests that the cerebellar disturbances
in Weaver predispose the normal synaptic remodelling
observed in wildtypes towards the formation of enlarged
terminals