97 research outputs found
Fractal Properties of Robust Strange Nonchaotic Attractors in Maps of Two or More Dimensions
We consider the existence of robust strange nonchaotic attractors (SNA's) in
a simple class of quasiperiodically forced systems. Rigorous results are
presented demonstrating that the resulting attractors are strange in the sense
that their box-counting dimension is N+1 while their information dimension is
N. We also show how these properties are manifested in numerical experiments.Comment: 9 pages, 14 figure
Intermittency transitions to strange nonchaotic attractors in a quasiperiodically driven Duffing oscillator
Different mechanisms for the creation of strange nonchaotic attractors (SNAs)
are studied in a two-frequency parametrically driven Duffing oscillator. We
focus on intermittency transitions in particular, and show that SNAs in this
system are created through quasiperiodic saddle-node bifurcations (Type-I
intermittency) as well as through a quasiperiodic subharmonic bifurcation
(Type-III intermittency). The intermittent attractors are characterized via a
number of Lyapunov measures including the behavior of the largest nontrivial
Lyapunov exponent and its variance as well as through distributions of
finite-time Lyapunov exponents. These attractors are ubiquitous in
quasiperiodically driven systems; the regions of occurrence of various SNAs are
identified in a phase diagram of the Duffing system.Comment: 24 pages, RevTeX 4, 12 EPS figure
Whole-genome array-CGH for detection of submicroscopic chromosomal imbalances in children with mental retardation
Chromosomal imbalances are the major cause of mental retardation (MR). Many of these imbalances are caused by submicroscopic deletions or duplications not detected by conventional cytogenetic methods. Microarray-based comparative genomic hybridization (array-CGH) is considered to be superior for the investigation of chromosomal aberrations in children with MR, and has been demonstrated to improve the diagnostic detection rate of these small chromosomal abnormalities. In this study we used 1 Mb genome-wide array-CGH to screen 48 children with MR and congenital malformations for submicroscopic chromosomal imbalances, where the underlying cause was unknown. All children were clinically investigated and subtelomere FISH analysis had been performed in all cases. Suspected microdeletion syndromes such as deletion 22q11.2, Williams-Beuren and Angelman syndromes were excluded before array-CGH analysis was performed. We identified de novo interstitial chromosomal imbalances in two patients (4%), and an interstitial deletion inherited from an affected mother in one patient (2%). In another two of the children (4%), suspected imbalances were detected but were also found in one of the non-affected parents. The yield of identified de novo alterations detected in this study is somewhat less than previously described, and might reflect the importance of which selection criterion of patients to be used before array-CGH analysis is performed. However, array-CGH proved to be a high-quality and reliable tool for genome-wide screening of MR patients of unknown etiology
Pressure-driven instabilities in astrophysical jets
Astrophysical jets are widely believed to be self-collimated by the
hoop-stress due to the azimuthal component of their magnetic field. However
this implies that the magnetic field is largely dominated by its azimuthal
component in the outer jet region. In the fusion context, it is well-known that
such configurations are highly unstable in static columns, leading to plasma
disruption. It has long been pointed out that a similar outcome may follow for
MHD jets, and the reasons preventing disruption are still not elucidated,
although some progress has been accomplished in the recent years.
In these notes, I review the present status of this open problem for
pressure-driven instabilities, one of the two major sources of ideal MHD
instability in static columns (the other one being current-driven
instabilities).
I first discuss in a heuristic way the origin of these instabilities.
Magnetic resonances and magnetic shear are introduced, and their role in
pressure-driven instabilities discussed in relation to Suydam's criterion. A
dispersion relation is derived for pressure-driven modes in the limit of large
azimuthal magnetic fields, which gives back the two criteria derived by
Kadomtsev for this instability. The growth rates of these instabilities are
expected to be short in comparison with the jet propagation time.
What is known about the potential stabilizing role of the axial velocity of
jets is then reviewed. In particular, a nonlinear stabilization mechanism
recently identified in the fusion literature is discussed.
Key words: Ideal MHD: stability, pressure-driven modes; Jets: stabilityComment: 20 pages, 3 figures. Lecture given at the JETSET European school
"Numerical MHD and Instabilities". To be published by Springer in the
"Lectures notes in physics" serie
The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-κB transcriptional activity in models of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease that produces synovial proliferation and joint erosions. The pathologic lesions of RA are driven through the production of inflammatory mediators in the synovium mediated, in part, by the transcription factor NF-κB. We have identified a non-steroidal estrogen receptor ligand, WAY-169916, that selectively inhibits NF-κB transcriptional activity but is devoid of conventional estrogenic activity. The activity of WAY-169916 was monitored in two models of arthritis, the HLA-B27 transgenic rat and the Lewis rat adjuvant-induced model, after daily oral administration. In both models, a near complete reversal in hindpaw scores was observed as well as marked improvements in the histological scores. In the Lewis rat adjuvant model, WAY-169916 markedly suppresses the adjuvant induction of three serum acute phase proteins: haptoglobin, α1-acid glycoprotein (α1-AGP), and C-reactive protein (CRP). Gene expression experiments also demonstrate a global suppression of adjuvant-induced gene expression in the spleen, liver, and popliteal lymph nodes. Finally, WAY-169916 was effective in suppressing tumor necrosis factor-α-mediated inflammatory gene expression in fibroblast-like synoviocytes isolated from patients with RA. Together, these data suggest the utility of WAY-169916, and other compounds in its class, in treating RA through global suppression of inflammation via selective blockade of NF-κB transcriptional activity
Efficiency and scaling of current drive and refuelling by spheromak injection into a tokamak
X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes
X-linked intellectual disability (XLID) is a clinically and genetically heterogeneous disorder. During the past two decades in excess of 100 X-chromosome ID genes have been identified. Yet, a large number of families mapping to the X-chromosome remained unresolved suggesting that more XLID genes or loci are yet to be identified. Here, we have investigated 405 unresolved families with XLID. We employed massively parallel sequencing of all X-chromosome exons in the index males. The majority of these males were previously tested negative for copy number variations and for mutations in a subset of known XLID genes by Sanger sequencing. In total, 745 X-chromosomal genes were screened. After stringent filtering, a total of 1297 non-recurrent exonic variants remained for prioritization. Co-segregation analysis of potential clinically relevant changes revealed that 80 families (20%) carried pathogenic variants in established XLID genes. In 19 families, we detected likely causative protein truncating and missense variants in 7 novel and validated XLID genes (CLCN4, CNKSR2, FRMPD4, KLHL15, LAS1L, RLIM and USP27X) and potentially deleterious variants in 2 novel candidate XLID genes (CDK16 and TAF1). We show that the CLCN4 and CNKSR2 variants impair protein functions as indicated by electrophysiological studies and altered differentiation of cultured primary neurons from Clcn4−/− mice or after mRNA knock-down. The newly identified and candidate XLID proteins belong to pathways and networks with established roles in cognitive function and intellectual disability in particular. We suggest that systematic sequencing of all X-chromosomal genes in a cohort of patients with genetic evidence for X-chromosome locus involvement may resolve up to 58% of Fragile X-negative cases
FOXO1, PXK, PYCARD and SAMD9L are differentially expressed by fibroblast-like cells in equine synovial membrane compared to joint capsule
Abstract Background The synovial membrane lines the luminal side of the joint capsule in synovial joints. It maintains joint homeostasis and plays a crucial role in equine joint pathology. When trauma or inflammation is induced in a joint, the synovial membrane influences progression of joint damage. Equine synovial membrane research is hampered by a lack of markers of fibroblast-like synoviocytes (FLS) to distinguish FLS from other fibroblast-like cells in musculoskeletal connective tissues. The aim of this study is to identify potential FLS markers of the equine synovial membrane using microarray to compare between gene expression in equine synovial membrane and the joint capsule in metacarpophalangeal joints. Results Microarray analysis of tissues from 6 horses resulted in 1167 up-regulated genes in synovial membrane compared with joint capsule. Pathway analysis resulted in 241 candidate genes. Of these, 15 genes were selected for further confirmation as genes potentially expressed by fibroblast-like synoviocytes. Four genes: FOXO1, PXK, PYCARD and SAMD9L were confirmed in 9 horses by qPCR as differentially expressed in synovial membrane compared to joint capsule. Conclusions In conclusion, FOXO1, PXK, PYCARD and SAMD9L were confirmed as differentially expressed in synovial membrane compared to joint capsule. These four genes are potential markers of fibroblast-like synoviocytes of the synovial membrane. As these genes are overexpressed in synovial membrane compared to joint capsule, these genes could shed light on synovial membrane physiology and its role in joint disease
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