Fractional derivatives of the generalized Mittag-Leffler functions

Abstract In this paper, we derive the compositions of the fractional derivatives with the Shukla function, a four-parameter Mittag-Leffler function. We investigate and compare the difference between the Riemann–Liouville and Caputo derivatives of the generalized Mittag-Leffler functions and obtain the reason causing the difference and expand the fractional derivatives of the generalized Mittag-Leffler functions. Two illustrative examples and the related numerical results are provided to demonstrate the validity

HYPOTENSIVE ACTIVITY OF METHANOLIC EXTRACT OF BERBERIS VULGARIS (ROOT PULP AND BARK)

ABSTRACT Many plants have been recommended in alternative systems of medicine for hypotensive activity although few systematic studies have been done. In this study, the hypotensive activity was studied in normotensive albino rats at different doses of BRPM and BB. The receptor activity was assessed by the drugs Ach on rat heart. Administration of different methanolic extract (BRPM, BB) showed significant reduction in blood pressure comparable to its respective control. Both methanolic extract completely blocked the Ach receptors in heart. This study suggests that the methanolic extract (BRPM, BB) have significant Ach receptor blocking and hypotensive activity and may be recommended for further investigation

The impact of pumpkin seed-derived silver nanoparticles on corrosion and cytotoxicity: a molecular docking study of the simulated AgNPs

ABSTRACTGreen-synthesized nanoparticles from pumpkin (Cucurbita pepo L.) seed extracts are economical and eco-friendly. Silver nanoparticles (AgNPs) and their selective cytotoxicity towards HCT116 and African Green Monkey Kidney, Vero cells were investigated. Chemical fingerprinting, heat stability, and 2D-images of nanoparticle size and morphology were determined using Fourier-transform infrared spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Transmission Electron Microscopy (TEM), and Scanning electron microscopy-energy dispersive X-ray (SEM-EDX) on AgNPs. UV-vis examination shows surface plasmons in the wide peak at 417 nm, indicating polydisperse nanoparticles. Small silver nanoparticles (AgNPs) below 2 µm demonstrated a rod-like form and a tendency to agglomerate. SEM-EDX element analysis and fingerprinting confirmed the material as AgNPs. TEM indicated that the nanoparticles were generally spherical or ellipsoidal, equally dispersed, and averaged 26.08 nm in diameter with negligible aggregation. The AgNPs are also stable at a temperature of 220°C, indicating that the green material is quite robust at 150°C to 400°C. According to cytotoxic studies, AgNPs are toxic to cancer cells (HCT 116 cells), however they have no effect on Vero cells. AgNPs and tubulin (TUB) domain active sites have a significant affinity, according to molecular docking analysis. In an electrochemical investigation, biogenic AgNPs effectively prevented mild steel from corroding in a 1.0 M HCl solution

Association Mechanism and Conformational Changes in Trypsin on Its Interaction with Atrazine: A Multi- Spectroscopic and Biochemical Study with Computational Approach

Atrazine (ATR) is a herbicide globally used to eliminate undesired weeds. Herbicide usage leads to various adverse effects on human health and the environment. The primary source of herbicides in humans is the food laced with the herbicides. The ATR binding to trypsin (TYP) was investigated in this study to explore its binding potential and toxicity. In vitro interaction of ATR with TYP was studied using multi-spectroscopic methods, molecular docking, and enzyme kinetics to explore the mechanism of binding for the TYP-ATR system. The TYP-ATR complex revealed binding constants (103 M−1), suggesting a moderate binding. The free energy for the TYP-ATR complexes was negative, suggesting a spontaneous interaction. Thermodynamic parameters enthalpy (ΔH) and entropy (ΔS) obtained positive values for the TYP-ATR system suggesting hydrophobic interactions in the binding process. Micro-environmental and conformational changes in TYP molecules were induced on interaction with ATR. Reduced catalytic activity of TYP was observed after interaction with ATR owing to the changes in the secondary structure of the TYP

Feasibility and Product Maturity of Compost Developed from Poultry Waste in Temperate Agroclimate of Kashmir Region

Present work was carried out in the Department of LPM, FVSc and AH (SKUAST- Kashmir) to assess the feasibility and compost maturity in terms of temperature and bio-mineral (Nitrogen, Phosphorus and Potassium) changes due to composting of poultry waste under the temperate agro-climatic conditions of Kashmir Valley. Poultry waste in the form of poultry carcass (including feathers) and litter manure was used for this study. Four treatment groups with four replicates each were formulated as: G1: Poultry carcass; litter manure, G2: Poultry carcass; litter manure; Paddy straw, G3: Poultry carcass; litter manure; effective microbes (Lactobacillus plantarum, Lactobacillus casei, Saccharomyces cerevisiae and Rhodopseudomonas palustris) and G4: Poultry carcass; litter manure; Paddy straw; effective microbes. During the primary stage of composting the group G4 had attained a significantly (P<0.05) highest peak temperature (0C) of 59.0±5.04 and 59.50±5.04 respectively during winter and summer seasons. Significantly (P<0.05) highest nitrogen content of 24.7 g/Kg was observed in group G4 at the end of secondary stage during summer season. The phosphorus content in end product of composting was significantly (P<0.05) highest (1.0 g/Kg) in group G4 during summer season. Similarly significantly (P<0.05) highest K content of 10.23 g/Kg was observed in group G4 during summer season. It was concluded that the addition of paddy straw and effective microbes assistant the composting process and yield better bio-mineral values and higher temperature gain