MECHANISM OF LANDING STRATERGY DURING STEP AEROBICS WITH DIFFERENT BENCH HEIGHTS AND LOADS

The purpose of this study was to investigate effects of different heights (6inch, 8inch, 10inch) and external loads (0% BW, 10% BW, 15% BW) on lower extremity during step aerobics. Ten college physical education students (age: 23.8 ± 2.1 years, height: 173.5 ± 6.1 cm, weight: 68.5 ± 8.0 kg) participated in this study. A Mega high-speed camera (100 Hz) and an ATMI force plate (1000Hz) were used to record kinematic and kinetic data respectively during step aerobics. Increased vertical ground reaction force, ankle movement, and decreased leg stiffness and ankle joint stiffness were found as the bench height increased to 10 inches which were considered to a high loading rates and shock to the lower extremity, especially at ankle joint. Therefore, people should avoid doing step aerobics at 10-inch bench height for a long time to protect ankle joint and soft tissue from injury

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin.

Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes a secreted protein that inhibits extracellular LPL and promotes adipocyte lipolysis. In Angptl4 null mice, glucocorticoid-induced adipocyte lipolysis and hepatic steatosis are compromised. Markedly, insulin suppressed glucocorticoid-induced Angptl4 transcription. To unravel the mechanism, we utilized small molecules to inhibit insulin signaling components and found that phosphatidylinositol 3-kinase and Akt were vital for the suppression in H4IIE cells. A forkhead box transcription factor response element (FRE) was found near the 15 bp Angptl4 glucocorticoid response element (GRE). Mutating the Angptl4 FRE significantly reduced glucocorticoid-induced reporter gene expression in cells. Moreover, chromatin immunoprecipitation revealed that GR and FoxO1 were recruited to Angptl4 GRE and FRE in a glucocorticoid-dependent manner, and cotreatment with insulin abolished both recruitments. Furthermore, in 24 h fasted mice, significant occupancy of GR and FoxO1 at the Angptl4 GRE and FRE was found in the liver. In contrast, both occupancies were diminished after 24 h refeeding. Finally, overexpression of dominant negative FoxO1 mutant abolished glucocorticoid-induced Angptl4 expression, mimicking the insulin suppression. Overall, we demonstrate that both GR and FoxO1 are required for Angptl4 transcription activation, and that FoxO1 negatively mediates the suppressive effect of insulin

Connections of geometric measure of entanglement of pure symmetric states to quantum state estimation

We study the geometric measure of entanglement (GM) of pure symmetric states related to rank-one positive-operator-valued measures (POVMs) and establish a general connection with quantum state estimation theory, especially the maximum likelihood principle. Based on this connection, we provide a method for computing the GM of these states and demonstrate its additivity property under certain conditions. In particular, we prove the additivity of the GM of pure symmetric multiqubit states whose Majorana points under Majorana representation are distributed within a half sphere, including all pure symmetric three-qubit states. We then introduce a family of symmetric states that are generated from mutually unbiased bases (MUBs), and derive an analytical formula for their GM. These states include Dicke states as special cases, which have already been realized in experiments. We also derive the GM of symmetric states generated from symmetric informationally complete POVMs (SIC~POVMs) and use it to characterize all inequivalent SIC~POVMs in three-dimensional Hilbert space that are covariant with respect to the Heisenberg--Weyl group. Finally, we describe an experimental scheme for creating the symmetric multiqubit states studied in this article and a possible scheme for measuring the permanent of the related Gram matrix.Comment: 11 pages, 1 figure, published versio

Relationships between serum HER2 ECD, TIMP-1 and clinical outcomes in Taiwanese breast cancer

<p>Abstract</p> <p>Background</p> <p>Serum levels of the extracellular domain of HER2/neu (HER2 ECD) have been demonstrated to be associated with clinical outcomes. A disintegrin and metalloproteinase-10, a sheddase of HER2/neu, can drive cancer progression and its activity is inhibited by tissue inhibitor of metalloproteinase-1 (TIMP-1). However, elevated TIMP-1 expression has been associated with a poor prognosis of breast cancer. Therefore, this study was performed to explore the relationships between serum HER2 ECD, TIMP-1 and clinical outcomes.</p> <p>Methods</p> <p>One hundred and eighty-five female breast cancer patients, who received curative mastectomy without neo-adjuvant chemotherapy at Chang-Gung Memorial Hospital, were recruited with informed consent for this study. Pre-operative serum levels of HER2 ECD and TIMP-1 were measured using an enzyme-linked immunosorbent assay.</p> <p>Results</p> <p>Twenty-three cases (12.4%) were classified HER2 ECD positive. HER2 ECD positivity was significantly associated with age, lymph node involvement, histological grade, estrogen receptor status, progesterone receptor status, tissue HER2/neu overexpression, and disease-free survival (DFS). In an age, stage, ER and HER2/neu status matched subgroup (N = 41), the serum level of TIMP-1 was significantly associated with HER2 ECD positivity and DFS.</p> <p>Conclusions</p> <p>A high serum TIMP-1 was significantly associated with HER2 ECD positivity and a poorer DFS among Taiwanese primary breast cancer patients with HER2 overexpression.</p