External bioelectrodes - A battery substitute for biological telemetry systems Final report, period ending 28 Feb. 1966

Electrode pair power output in saline and on skin for determination of telemetry system power source material

Multi-field open inflation model and multi-field dynamics in tunneling

We consider a multi-field open inflation model, in which one of the fields dominates quantum tunneling from a false vacuum while the other field governs slow-roll inflation within the bubble nucleated from false vacuum decay. We call the former the tunneling field and the latter the inflaton field. In the limit of a negligible interaction between the two fields, the false vacuum decay is described by a Coleman-De Luccia instanton. Here we take into account the coupling between the two fields and construct explicitly a multi-field instanton for a simple quartic potential model. We also solve the evolution of the scalar fields within the bubble. We find our model realizes open inflation successfully. This is the first concrete, viable model of open inflation realized with a simple potential. We then study the effect of the multi-field dynamics on the false vacuum decay, specifically on the tunneling rate. We find the tunneling rate increases in general in comparison with the single field case, though the increase is small unless the inflaton affects the instanton solution substantially.Comment: 13 pages, 4 figure

Exploring a string-like landscape

We explore inflationary trajectories within randomly-generated two-dimensional potentials, considered as a toy model of the string landscape. Both the background and perturbation equations are solved numerically, the latter using the two-field formalism of Peterson and Tegmark which fully incorporates the effect of isocurvature perturbations. Sufficient inflation is a rare event, occurring for only roughly one in $10^5$ potentials. For models generating sufficient inflation, we find that the majority of runs satisfy current constraints from WMAP. The scalar spectral index is less than 1 in all runs. The tensor-to-scalar ratio is below the current limit, while typically large enough to be detected by next-generation CMB experiments and perhaps also by Planck. In many cases the inflationary consistency equation is broken by the effect of isocurvature modes.Comment: 24 pages with 8 figures incorporated, matches version accepted by JCA

“Exploring the Basement of Social Justice Issues”: A Graduate Upon Graduation

Photograph of rides building up, taken J. Stevens' Fair, 20 June 1961 whole general view, looking West. See Leeson's notebook 9, pages 92-95 for notes

Precision medicine approaches for diabetic kidney disease:opportunities and challenges

The prevalence of end-stage kidney disease (ESKD) continuously increases worldwide. The increasing prevalence parallels the growth in the number of people with diabetes, which is the leading cause of ESKD. Early diagnosis of chronic kidney disease (CKD) in patients with diabetes and appropriate intervention is important to delay the progression of kidney function decline and prevent ESKD. Rate of CKD progression and response to treatment varies among patients with diabetes, highlighting the need to tailor individual treatment. In this review, we describe recent advances and areas for future studies with respect to precision medicine in diabetic kidney disease (DKD). DKD is a multi-factorial disease that is subject in part to genetic heritability, but is also influenced by various exogenous mediators, such as environmental or dietary factors. Genetic testing so far has limited utility to facilitate early diagnosis, classify progression or evaluate response to therapy. Various biomarker-based approaches are currently explored to identify patients at high risk of ESKD and to facilitate decision-making for targeted therapy. These studies have led to discovery and validation of a couple of inflammatory proteins such as circulating tumour necrosis factor receptors, which are strong predictors of kidney disease progression. Moreover, risk and drug-response scores based on multiple biomarkers are developed to predict kidney disease progression and long-term drug efficacy. These findings, if implemented in clinical practice, will pave the way to move from a one-size-fits-all to a one-fit-for-everyone approach

Accelerating universe emergent from the landscape

We propose that the existence of the string landscape suggests the universe can be in a quantum glass state, where an extremely large viscosity is generated, and long distance dynamics slows down. At the same time, the short distance dynamics is not altered due to the separation of time scales. This scenario can help to understand some controversies in cosmology, for example the natural existence of slow roll inflation and dark energy in the landscape, the apparent smallness of the cosmological constant. We see also that moduli stabilization is no longer necessary. We further identify the glass transition point, where the viscosity diverges, as the location of the cosmic horizon. We try to reconstruct the geometry of the accelerating universe from the structure of the landscape, and find that the metric should have an infinite jump when crossing the horizon. We predict that the static coordinate metric for dS space breaks down outside the horizon.Comment: 20 pages, no figures, harvma

Brane Inflation and the Overshoot Problem

We investigate recent claims that brane inflation solves the overshoot problem through a combination of microphysical restrictions on the phase space of initial conditions and the existence of the Dirac-Born-Infeld (DBI) attractor in regimes where the slow-roll attractor does not apply. Carrying out a comprehensive analysis of the parameter space allowed by the latest advances in brane inflation model-building, we find that these restrictions are insufficient to solve the overshoot problem. The vast majority of the phase space of initial conditions is still dominated by overshoot trajectories. We present an analytic proof that the brane-inflationary attractor must be close to the slow-roll limit, and update the predictions for observables such as non-Gaussianity, cosmic string tension and tensor modes.Comment: 14 pages, 3 figures, matches version published in PRD. Minor clarifications, references adde

Cosmology of the Tachyon in Brane Inflation

In certain implementations of the brane inflationary paradigm, the exit from inflation occurs when the branes annihilate through tachyon condensation. We investigate various cosmological effects produced by this tachyonic era. We find that only a very small region of the parameter space (corresponding to slow-roll with tiny inflaton mass) allows for the tachyon to contribute some e-folds to inflation. In addition, non-adiabatic density perturbations are generated at the end of inflation. When the brane is moving relativistically this contribution can be of the same order as fluctuations produced 55 e-folds before the end of inflation. The additional contribution is very nearly scale-invariant and enhances the tensor/scalar ratio. Additional non-gaussianities will also be generated, sharpening current constraints on DBI-type models which already predict a significantly non-gaussian signal.Comment: 30 pages, 2 figures; v3, minor revision, JCAP versio