Attitude of students-medicines to family values

The family is one of the main values of the person, as all people at different age periods of his life are connected with it. The family is the first cell of society, spiritual education, socio-economic unit. However, the family development and change of its functions are gradually changing the value attitude to it among modern youth. The article presents the results of a study aimed at the identification of opinions about the attitude to the family values of students of the Ural state medical University (Yekaterinburg).Семья — одна из главных ценностей личности, так как все люди на разных возрастных периодах своей жизни связаны именно с ней. Семья — первая ячейка общества, духовное образование, социоэкономическая единица. Однако развитие семьи и изменение ее функций постепенно меняют ценностное отношение к ней у современной молодежи. В статье представлены результаты исследования, направленного на выявление мнений об отношении к семейным ценностям студентов Уральского государственного медицинского университета (г. Екатеринбург)

Business - plan the medical clinic "Osteopathy" in Verkhnyaya Pyshma

A marketing study was Conducted to develop a business plan of the medical clinic "Osteopathy" in the city of Verkhnyaya Pyshma. Economic calculations to assess the profitability of the project.Проведено маркетинговое исследование с целью разработки бизнес-плана медицинской клиники "Остеопатия" в городе Верхняя Пышма. Проведены экономические расчеты по оценке рентабельности проекта

The New Strategy for Studying Drug-Delivery Systems with Prolonged Release: Seven-Day In Vitro Antibacterial Action

The new method of antibacterial-drug-activity investigation in vitro is proposed as a powerful strategy for understanding how carriers affect drug action during long periods (7 days). In this paper, we observed fluoroquinolone moxifloxacin (MF) antibacterial-efficiency in non-covalent complexes, with the sulfobutyl ether derivative of β-cyclodextrin (SCD) and its polymer (SCDpol). We conducted in vitro studies on two Escherichia coli strains that differed in surface morphology. It was found that MF loses its antibacterial action after 3–4 days in liquid media, whereas the inclusion of the drug in SCD led to the increase of MF antibacterial activity by up to 1.4 times within 1–5 days of the experiment. In the case of MF-SCDpol, we observed a 12-fold increase in the MF action, and a tendency to prolonged antibacterial activity. We visualized this phenomenon (the state of bacteria, cell membrane, and surface morphology) during MF and MF-carrier exposure by TEM. SCD and SCDpol did not change the drug’s mechanism of action. Particle adsorption on cells was the crucial factor for determining the observed effects. The proteinaceous fimbriae on the bacteria surface gave a 2-fold increase of the drug carrier adsorption, hence the strains with fimbriae are more preferable for the proposed treatment. Furthermore, the approach to visualize the CD polymer adsorption on bacteria via TEM is suggested. We hope that the proposed comprehensive method will be useful for the studies of drug-delivery systems to uncover long-term antibacterial action

Cyclodextrins and Their Polymers Affect the Lipid Membrane Permeability and Increase Levofloxacin’s Antibacterial Activity In Vitro

Cyclodextrins (CDs) are promising drug carriers that are used in medicine. We chose CDs with different substituents (polar/apolar, charged/neutral) to obtain polymers (CDpols) with different properties. CDpols are urethanes with average Mw of ~120 kDa; they form nanoparticles 100–150 nm in diameter with variable ζ-potential. We studied the interaction of CD and CDpols with model (liposomal) and bacterial membranes. Both types of CD carriers cause an increase in the liposomal membrane permeability, and for polymers, this effect was almost two times stronger. The formation of CD/CDpols complexes with levofloxacin (LV) enhances LV’s antibacterial action 2-fold in vitro on five bacterial strains. The most pronounced effect was determined for LV-CD complexes. LV-CDs and LV-CDpols adsorb on bacteria, and cell morphology influences this process dramatically. According to TEM studies, the rough surface and proteinaceous fimbria of Gram-negative E. coli facilitate the adsorption of CD particles, whereas the smooth surface of Gram-positive bacteria impedes it. In comparison with LV-CDs, LV-CDpols are adsorbed 15% more effectively by E. coli, 2.3-fold better by lactobacilli and 5-fold better in the case of B. subtilis. CDs and CDpols are not toxic for bacterial cells, but may cause mild defects that, in addition to LV-CD carrier adsorption, improve LV’s antibacterial properties