40 research outputs found
Elimination of Graft Versus Host Disease in Matched Allogeneic Leukemic Transplant Recipients Using Campath-1
Subpopulations of T Cells in the Rat that Mediate Graft-Versus-Host Reactions and Lethal Graft-Versus-Host Disease
Identification of mature plasma cells in early rat yolk sac. A possible origin from the endodermal cell layer: Immunohistochemistry and immunoelectron microscopic study
Enzyme replacement treatment for Tay-Sachs disease brain cells in culture utilizing Concanavalin A-mediated hexosaminidase A uptake: Biochemical and morphological evidence of GM2 mobilization
Immunosenescence: emerging challenges for an ageing population
It is now becoming apparent that the immune system undergoes age-associated alterations, which accumulate to produce a progressive deterioration in the ability to respond to infections and to develop immunity after vaccination, both of which are associated with a higher mortality rate in the elderly. Immunosenescence, defined as the changes in the immune system associated with age, has been gathering interest in the scientific and health-care sectors alike. The rise in its recognition is both pertinent and timely given the increasing average age and the corresponding failure to increase healthy life expectancy. This review attempts to highlight the age-dependent defects in the innate and adaptive immune systems. While discussing the mechanisms that contribute to immunosenescence, with emphasis on the extrinsic factors, particular attention will be focused on thymic involution. Finally, we illuminate potential therapies that could be employed to help us live a longer, fuller and healthier life