On the Structure of ZnI2{\rm ZnI_2}

A new structure for ${\rm ZnI_2}$ is proposed which it exists in tetragonal state. In this structure the ${\rm ZnI_2}$ molecule exists in a nonlinear array and forms the basis of the tetragonal unit cell with one basis per unit cell. The structural analysis based on the reflections listed in ASTM 30-1479 shows that the proposed structure is correct.Comment: six pages and four figures. Manuscript prepared in RevTe

Zinc Finger Proteins: Epigenetic Breakthroughs and Possible Treatment of Neurodegenerative Disorders

Engineered zinc finger proteins (ZFN) that bind specific DNA targets provide the foundation for a new class of technologies that promise significant gains in the development of novel therapeutics and molecular research tools. Individual zinc fingers have been developed in vitro to recognize many DNA triplets. When fused to the nonspecific DNA cleavage domain of the FOK1 restriction endonuclease, zinc fingers can direct double strand breaks to disrupt specific genes. Expanded triplet repeats have been identified as the genetic basis for a growing number of neurological disorders. Thus ZFN show promise for the treatment of monogenic disorders by promoting the knockout or correction of specific genes

Gel Electrophoretic Determination of Atrial Natriuretic Peptide and its Truncated Peptide

Atrial natriuretic peptide (ANP) is released from the heart and induces the elicitation of guanylate cyclase enzyme activity. It has vasodilatory and natriuretic properties. In this study we elucidated the determination of ANP deoxyribonucleotide (DNA) and its truncated peptide ANP (4-28) by agarose gel electrophoresis. The techniques combined the use of polymerase chain reaction and gel electrophoresis for simple estimation of DNA content from biological samples

Immunoglobulins may Modulate the Formation of Triple Helix DNA in Pathophysiological States

The Runt domain proteins are comprised mostly of b-strands arranged in an antiparallel fashion to from a b barrel with an s-type immunoglobulin fold. It is interesting to note that the same fold is used in the DNA binding domains of several transcription factors. A common feature is that DNA binding is mediated by loops that extend from one end of the Ig-motif. These proteins bind to different DNA sequences and specific recognition is accounted for by variations in the details of the molecular interactions between the loop regions and the DNA. This review suggests that immunoglobulin fold proteins may play a key role in modulation and formation of triple helix DNA structure with implications for patho-physiological states

Tramadol Potentiates Vasopressin Induced Analgesia in Albino Mice

The effect of centrally acting opioid analgesic Tramadol on vasopressin induced analgesia was evaluated in Swiss albino mice. Analgesia was evaluated in the mice using tail clip and writhing test techniques. Animals were divided into control and test groups (n=6).Arginine vasopressin (12 µg/kg i.p) and its synthetic analogue, Terlipressin (300 µg /kg i.v) injected in the mice produced analgesia by increasing the latency period by 131.6% and 53.5% respectively and reduced the acetic acid writhing by 45.85 % and 13.51 % respectively. Pretreatment with Tramadol (10 mg/kg i.p) potentiated the analgesic action of vasopressin and terlipressin  and increased the latency period and reduced the acetic acid induced writhings respectively. This study suggests that Tramadol can be combined with vasopressin for enhanced analgesic effect

Supply chain integration through ship routing optimization among BRICS by using meta-heuristic technique

397-402Acquiring and distribution of goods among BRICS countries by way of supply chain integration through route optimization of a fleet of vessels to serve customers of coined members with minimum total cost and sum of demurrage cost (charged by port) and detention cost (charged by ocean carriers), arising from earliness and tardiness in ship’s arrival at ports with respect to the delivery deadlines of customers, is a homogeneous heterogeneous ship routing problem with time window (HHSRPTW), which involves the routing of a set of ships with known demands and predefined time windows as well as delivery time. To solve the problem, this study proposes a genetic algorithm as an optimization technique and MATLAB as a software tool

Blood transfusion practices in obstetrics and gynecology: study of indications as a measure to prevent maternal morbidity and mortality

Background: This is a study of rational use of blood transfusion in a tertiary care center. So, this study was done to find out the indications of blood transfusion in department of obstetrics and gynaecology and measures to minimize the requirement of blood transfusion to reduce maternal mortality and morbidity.Methods: This is a retrospective study in department of obstetrics and gynaecologyin Muzaffarnagar Medical College, Muzaffarnagar, U.P. in collaboration with the department of pathology including blood bank for the duration of 1 year i.e. 1st January, 2017 to 31st December, 2017.  Total transfusions in 1 year were 706 of which 406 were in obstetrics and 300 were in gynecology.Results: In our study maximum 16.20% blood transfusions were given during cesarean section in third trimester in unbooked cases who came with severe anemia in labour. Others were APH (12%) and abortions (13.05%). This shows that anemia is still a major cause of maternal mortality and morbidity in India. In Gynecological cases blood transfusion was more in third parity and above indicating that perimenopausal women were also more susceptible for anemia due to disease of perimenopausal age group like AUB and fibroid.Conclusions: Maximum number of transfusions specially PRBC in obstetrics were of moderate to severe anemia, mainly to the patients who were term or in labor and of high-risk pregnancies, who were unbooked with no antenatal care. In Gynecology cases, blood transfusion was of perimenopausal or menopausal group with moderate anemia. This comes to the conclusion that all preventive measures should be taken in females from womb to tomb to correct anemia and this will indirectly help to prevent maternal and perinatal morbidity and mortality