118 research outputs found
The Efficacy, Safety, and Immunogenicity of Switching Between Reference Biopharmaceuticals and Biosimilars: A Systematic Review
To date, no consensus exists among stakeholders about the safety of switching between reference biological products (RPs) and biosimilars, which may have been curbing the implementation of biosimilars in clinical practice. This study synthesizes the available data on switching and assesses whether switching patients from a RP to its biosimilar or vice versa affects efficacy, safety, or immunogenicity outcomes. A total of 178 studies, in which switch outcomes from a RP to a biosimilar were reported, was identified. Data were derived from both randomized controlled trials and real-world evidence. Despite the limitations stemming from a lack of a robust design for most of the studies, the available switching data do not indicate that switching from a RP to a biosimilar is associated with any major efficacy, safety, or immunogenicity issues. Some open-label and observational studies reported increased discontinuation rates after switching, which were mainly attributed to nocebo effects. Involvement of the prescriber in any decision to switch should remain and attention should be paid to the mitigation of a potential nocebo effect
Tiny houses. Does size matter?
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174312pub.pdf (publisher's version ) (Open Access)8 p
In appartementsrechten gesplitste erfpacht
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93073pub.pdf (publisher's version ) (Open Access)7 p
Bescherming van derivatenbeleggers via een afgescheiden vermogen in de Wet giraal effectenverkeer
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157023pub.pdf (publisher's version ) (Closed access)4 p
Lossingsrecht en executoriale verkoop door een beslaglegger
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85698.pdf (publisher's version ) (Closed access)8 p
Reactie op rechtsvraag âKan een drijvende woning in appartementen worden gesplitst?â in WPNR 2017/7150
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174017pub.pdf (publisher's version ) (Open Access)2 p
Noot bij: Rb. Midden-Nederland 27 februari 2013, JOR, 2013, 220 (Renvooiprocedure. Ontstaansmoment retributievorderingen)
Item does not contain fulltext27 februari 201
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