Catheter insertion simulation with co-registered direct volume rendering and haptic feedback

We have developed an experimental catheter insertion simulation system supporting head-tracked stereoscopic viewing of volumetric anatomic reconstructions registered with direct haptic 3D interaction. The system takes as input data acquired with standard medical imaging modalities and regards it as a visual and haptic environment whose parameters are interactively defined using look-up tables. The system's display, positioned like a surgical table, provide a realistic impression of looking down at the patient. Measuring head motion via a six degrees-of-freedom head tracker, good positions to observe the anatomy and identify the catheter insertion point are quickly established with simple head motion. By generating appropriate stereoscopic images and co-registering physical and virtual spaces beforehand, volumes appear at fixed physical positions and it is possible to control catheter insertion via direct interaction with a PHANToM haptic device. During the insertion procedure, the system provides perception of the effort of penetration and deviation inside the traversed tissues. Semi-transparent volumetric rendering augment the sensory feedback with the visual indication of the inserted catheter position inside the body.96-9

Catheter insertion simulation with combined visual and haptic feedback

We have developed an experimental catheter insertion system supporting head-tracked stereoscopic viewing of volumetric reconstruction registered with direct haptic 3D interaction. The system takes as input patient data acquired with standard medical imaging modalities and regards it as a visual and haptic environment whose parameters are defined using look-up tables. By means of a mirror, the screen seems to be positioned like a surgical table providing the impression of looking down at the patient in a natural way. Co-registering physical and virtual spaces beforehand means that the patient appears at a fixed physical positionj on the surgical table and inside the workspace of the PHANToM device which controls catheter insertion. During the insertion procedure the system provides perception of the force of penetration and positional deviation of the inserted catheter

DART: the distributed agent based retrieval toolkit

The technology of search engines is evolving from indexing and classification of web resources based on keywords to more sophisticated techniques which take into account the meaning and the context of textual information and usage. Replying to query, commercial search engines face the user requests with a large amount of results, mostly useless or only partially related to the request; the subsequent refinement, operated downloading and examining as much pages as possible and simply ignoring whatever stays behind the first few pages, is left up to the user. Furthermore, architectures based on centralized indexes, allow commercial search engines to control the advertisement of online information, in contrast to P2P architectures that focus the attention on user requirements involving the end user in search engine maintenance and operation. To address such wishes, new search engines should focus on three key aspects: semantics, geo-referencing, collaboration/distribution. Semantic analysis lets to increase the results relevance. The geo-referencing of catalogued resources allows contextualisation based on user position. Collaboration distributes storage, processing, and trust on a world-wide network of nodes running on users’ computers, getting rid of bottlenecks and central points of failures. In this paper, we describe the studies, the concepts and the solutions developed in the DART project to introduce these three key features in a novel search engine architecture

A collaborative, semantic and context-aware search engine

Search engines help people to find information in the largest public knowledge system of the world: the Web. Unfortunately its size makes very complex to discover the right information. The users are faced lots of useless results forcing them to select one by one the most suitable. The new generation of search engines evolve from keyword-based indexing and classification to more sophisticated techniques considering the meaning, the context and the usage of information. We argue about the three key aspects: collaboration, geo-referencing and semantics. Collaboration distributes storage, processing and trust on a world-wide network of nodes running on users’ computers, getting rid of bottlenecks and central points of failures. The geo-referencing of catalogued resources allows contextualisation based on user position. Semantic analysis lets to increase the results relevance. In this paper, we expose the studies, the concepts and the solutions of a research project to introduce these three key features in a novel search engine architecture.213-21

Laparoscopic cholecystectomy for melanoma metastatic to the gallbladder: is it an adequate surgical procedure? Report of a case and review of the literature

<p>Abstract</p> <p>Background</p> <p>Only 2% to 4% of patients with melanoma will be diagnosed with gastrointestinal metastasis during the course of their disease. The most common sites of gastrointestinal metastases from melanoma include the small bowel (35%–67%), colon (9%–15%) and stomach (5%–7%), with a median survival of 6–10 months after surgery, and 18% survival at five years. Metastatic melanoma to the gallbladder is extremely rare and it is associated with a very poor prognosis.</p> <p>Case presentation</p> <p>We report a case of a 54-year old man presented to observation with diagnosis of 6.1 mm thick, Clark's level IV, ulcerated melanoma of the trunk, developing in the course of the disease metastatic involvement of the gallbladder as first site of recurrence, treated by laparoscopic cholecystectomy. To date only few cases of patients with metastatic melanoma of the gallbladder treated by this surgical procedure have been reported in literature.</p> <p>Conclusion</p> <p>Gallbladder metastasis represents a rare event as a first site of recurrence. It must be considered a possible expression of systemic disease also despite radiological absence of other metastatic lesions. Laparoscopic approach has a possible therapeutic role, but open surgery has also a concomitant diagnostic purpose because gives the possibility of manual exploration of abdominal cavity, useful particularly to reveal bowel metastatic lesions, not easily identifiable by preoperative imaging examinations.</p

Interactive Virtual Angioscopy

Virtual angioscopy is a non invasive medical procedure for exploring parts of the human vascular system. We have developed an interactive tool that takes as input data acquired with standard medical imaging modalities and regards it as a virtual environment to be interactively inspected. The system supports real-time navigation with stereoscopic direct volume rendering and dynamic endoscopic camera control, interactive tissue classification, and interactive point picking for morphological feature measurement. In this paper, we provide an overview of the system, discuss the techniques used in our prototype, and present experimental results on human data sets. The accompanying video-tape illustrates our approach with interactive sequences showing the examination of a human carotid artery

Catheter Insertion Simulation with co-registered Direct Volume Rendering and Haptic Feedback

We have developed an experimental catheter insertion simulation system supporting head-tracked stereoscopic viewing of volumetric anatomic reconstructions registered with direct haptic 3D interaction. The system takes as input data acquired with standard medical imaging modalities and regards it as a visual and haptic environment whose parameters are interactively defined using look-up tables. The system’s display, positioned like a surgical table, provide a realistic impression of looking down at the patient. Measuring head motion via a six degrees-of-freedom head tracker, good positions to observe the anatomy and identify the catheter insertion point are quickly established with simple head motion. By generating appropriate stereoscopic images and co-registering physical and virtual spaces beforehand, volumes appear at fixed physical positions and it is possible to control catheter insertion via direct interaction with a PHANToM haptic device. During the insertion procedure, the system provides perception of the effort of penetration and deviation inside the traversed tissues. Semitransparent volumetric rendering augment the sensory feedback with the visua

Antimicrobial activity of <i>Inula helenium</i> L. essential oil against Gram-positive and Gram-negative bacteria and <i>Candida</i> spp.

In this work we report results regarding the in vitro antimicrobial activity of Inula helenium L. dried root extracts obtained by stepwise supercritical fluid extraction (SFE) and by hydrodistillation (HD). Inula helenium L. (Compositae family) is a perennial plant widely occurring in Europe and East Asia. Its oil is one of the richest sources of sesquiterpenoid lactones, which have strong anthelminthic activity and have the potential to induce detoxifying enzymes. Inula helenium L. roots (C-040705130905) were purchased from Minardi (Bagnacavallo-Ravenna, Italy). Supercritical CO2 extraction was performed in a laboratory apparatus equipped with a 400 cm3 extraction vessel operated in the single-pass mode of passing CO2 through the fixed bed of charged vegetable particles. Extraction was carried out in a semibatch mode: batch charging of vegetable matter and continuous flow solvent. HD was performed for 4 h in a circulatory Clevenger-type apparatus up to exhaustion of the oil contained in the matrix, which was the same material as used in the SFE

Supercritical CO(2) extract of Cinnamomum zeylanicum: Chemical characterization and antityrosinase activity

The volatile oil of the bark of Cinnamomum zeylanicum was extracted by means of supercritical CO(2) fluid extraction in different conditions of pressure and temperature. Its chemical composition was characterized by GC-MS analysis. Nineteen compounds, which in the supercritical extract represented >95% of the oil, were identified. (E)-Cinnamaldehyde (77.1%), (E)-beta-caryophyllene (6.0%), a-terpineol (4.4%), and eugenol (3.0%) were found to be the major constituents. The SFE oil of cinnamon was screened for its biological activity about the formation of melanin in vitro. The extract showed antityrosinase activity and was able to reduce the formation of insoluble flakes of melanin from tyrosine. The oil also delayed the browning effect in apple homogenate. (E)-Cinnamaldehyde and eugenol were found to be mainly responsible of this inhibition effect

Energy expenditure in caving.

The aim of this study was to determine the energy expenditure of a group of cavers of both genders and different ages and experience during a 10 hour subterranean exploration, using portable metabolimeters. The impact of caving activity on body composition and hydration were also assessed through bioelectrical impedance, and nutritional habits of cavers surveyed. During cave activity, measured total energy expenditure (TEE) was in the range 225-287 kcal/h for women-men (MET = 4.1), respectively; subjects had an energy intake from food in the range 1000-1200 kcal, thus inadequate to restore lost calories. Bayesian statistical analysis estimated the effect of predictive variables on TEE, revealing that experienced subjects had a 5% lower TEE than the less skilled ones and that women required a comparatively larger energy expenditure than men to perform the same task. BIVA (bioelectrical impedance vector analysis) showed that subjects were within the range of normal hydration before and after cave activity, but bioelectrical changes indicated a reduction of extracellular water in men, which might result in hypo-osmolal dehydration in the case of prolonged underground exercise. All these facts should be considered when planning cave explorations, preparing training programs for subjects practising caving, and optimizing a diet for cavers. Further, information gathered through this study could be of value to reduce accidents in caves related to increase in fatigue