Effects of partial liquid ventilation on gas exchange and lung mechanics in healthy animals

Partial liquid ventilation with perfluorocarbon liquids has been shown to improve pulmonary gas exchange and lung mechanics in animals with acute respiratory failure. In this study, we aimed to investigate whether healthy animals would maintain effective gas exchange during partial liquid ventilation and, respiratory and mechanical properties of healthy lung would be well preserved at the long-term, following partial liquid ventilation trial

COMPARISON OF VENTILATORY SUPPORT WITH INTRATRACHEAL PERFLUOROCARBON ADMINISTRATION AND CONVENTIONAL MECHANICAL VENTILATION IN ANIMALS WITH ACUTE RESPIRATORY-FAILURE

We investigated the efficacy of intratracheal perfluorocarbon (PFC) administration combined with mechanical ventilation to support gas exchange in adult animals with acute respiratory failure. These were compared with a similar group of animals treated with continuous positive-pressure ventilation (CPPV) with respect to respiratory parameters and postmortem lung histology. After lung lavage with saline, 18 adult rabbits were divided into three groups (n = 6 per group). All groups received conventional CPPV Additionally, one group received intratracheal PFC administration at a volume of 18 ml/kg (corresponding to functional residual capacity) (PFC group); another received 18 ml/kg of saline administration (saline group), and the last had no further treatment (CPPV group). All groups were ventilated for 3 h using 100% oxygen, with the same ventilator settings of tidal volume of 12 ml/kg, respiratory frequency of 30/min, and positive end-expiratory pressure of 6 cm H2O. In the PFC group, Pa(O2) increased from 67.2 +/- 11.4 to 424.2 +/- 14 mm Hg and remained stable for 3 h with well-preserved Pa(CO2) values. Only in the PFC group were significant decreases in airway pressures and increase in respiratory system compliance seen. In the CPPV group, Pa(O2) stayed around 60 mm Hg and Pa(CO2) gradually increased. PFC treatment with conventional mechanical ventilation in acute respiratory failure proved to be a successful supportive technique to improve gas exchange at low inflation pressures

INTRATRACHEAL PERFLUOROCARBON ADMINISTRATION COMBINED WITH MECHANICAL VENTILATION IN EXPERIMENTAL RESPIRATORY-DISTRESS SYNDROME - DOSE-DEPENDENT IMPROVEMENT OF GAS-EXCHANGE

Objectives: To test the efficacy of intratracheal instillation of a perfluorocarbon, combined with conventional mechanical ventilation, as well as to establish the dose response of this application on pulmonary parameters in adult animals with acute respiratory failure

Evaluation of lung function after intratracheal perfluorocarbon administration in healthy animals

Objectives: To investigate the effects of partial liquid ventila tion (i.e., mechanical ventilation in combination with intratracheal administration of perfluorocarbon) on lung function, with particular attention to the integrity of the alveolocapillary membrane in healthy adult animals

INTRATRACHEAL PERFLUOROCARBON ADMINISTRATION AS AN AID IN THE VENTILATORY MANAGEMENT OF RESPIRATORY-DISTRESS SYNDROME

Background. Respiratory distress syndrome carries a high morbidity and mortality when treated with mechanical ventilation with positive end-expiratory pressure. Perfluorocarbon liquids are employed in liquid ventilation due to low surface tension and high gas solubility. To assess whether intratracheal administration of the perfluorocarbon, perflubron, in combination with conventional mechanical ventilation could be of therapeutic benefit in respiratory distress syndrome, the authors tested the effects of different doses of intratracheal perflubron administration on gas exchange and lung mechanics in adult animals with respiratory failure during a 6-h observation period

Comparison of pressure- and flow-triggered pressure-support ventilation on weaning parameters in patients recovering from acute respiratory failure

Objective: To compare the effects of pressure- and flow-triggered pressure-support ventilation on weaning parameters during recovery from acute respiratory failure